Anti-Sirt1 antibody, Mouse monoclonal
- CAS No.
- Chemical Name:
- Anti-Sirt1 antibody, Mouse monoclonal
- Synonyms
- Anti-Sirt1 antibody, Mouse monoclonal
- CBNumber:
- CB04669681
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Anti-Sirt1 antibody, Mouse monoclonal price More Price(1)
Anti-Sirt1 antibody, Mouse monoclonal Chemical Properties,Uses,Production
Uses
Anti-Sirt1 antibody, Mouse monoclonal has been used in:
- western blot analysis
- enzyme-linked immunosorbent assay (ELISA)
- immunohistochemical methods
General Description
Monoclonal Anti-Sirt1 (Sir2) (mouse IgG1 isotype) is derived from the hybridoma SIR11 produced by the fusion of mouse myeloma cells (NS1 cells) and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to amino acids at the C-terminus of mouse Sir2 with C-terminal added lysine. Sirt proteins are a family of proteins that are found in organisms ranging from bacteria to complex eukaryotes. Members of this family contain a 250 amino acid core domain that shares about 25-60% sequence identity. Sirtuin 1 (SIRT1) protein, a mammalian homolog of yeast Sir2, is a NAD-dependent histone deacetylase.
Biochem/physiol Actions
Sirt1 transfers acetyl groups from its protein substrates to ADP-ribose and synthesizes O-acetyl-ADP-ribose. Through histone deacetylation, Sirt1 may silence chromatin. It appears that Sirt1 NAD requirement makes this protein an important player in the pathway that leads to increased life span of several species through calorie restriction. Sirtuin 1 (SIRT1) plays an important role in neuronal proliferation?and vascular cells. It also plays an athero-protective role. Mutations in the SIRT1 gene affects the metabolism, cholesterol and fat deposition. SIRT1?has the ability to intermediate the insulin resistance through an inflammatory process, reactive oxygen species, gluconeogenesis and adiponectin level.
Anti-Sirt1 antibody, Mouse monoclonal Preparation Products And Raw materials
Raw materials
Preparation Products
Anti-Sirt1 antibody, Mouse monoclonal Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |