MCTR3
- CAS No.
- 1784701-63-8
- Chemical Name:
- MCTR3
- Synonyms
- MCTR3;4,7,9,11,16,19-Docosahexaenoic acid, 13-[[(2R)-2-amino-2-carboxyethyl]thio]-14-hydroxy-, (4Z,7Z,9E,11E,13R,14S,16Z,19Z)-
- CBNumber:
- CB04718633
- Molecular Formula:
- C25H37NO5S
- Molecular Weight:
- 463.63
- MDL Number:
- MOL File:
- 1784701-63-8.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
| NFPA 704 |
|
MCTR3 price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19067 | MCTR3 | 1784701-63-8 | 50μg | $653 | 2024-03-01 | Buy |
| Cayman Chemical | 19067 | MCTR3 | 1784701-63-8 | 100μg | $943 | 2024-03-01 | Buy |
| Cayman Chemical | 19067 | MCTR3 | 1784701-63-8 | 10μg | $145 | 2024-03-01 | Buy |
| Cayman Chemical | 19067 | MCTR3 | 1784701-63-8 | 25μg | $344 | 2024-03-01 | Buy |
MCTR3 Chemical Properties,Uses,Production
Description
Maresin conjugates in tissue regeneration 3 (MCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; ) in macrophages.1,2 DHA is oxidized to maresin 1 (MaR1; ), which is converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase, then to MCTR2 by γ-glutamyl transferase, and to MCTR3 by dipeptidase.3 MCTR3 accelerates tissue regeneration in planaria (1 and 100 nM) approximately as potently as MCTR2 and more potently than MCTR1.2 Pretreatment with MCTR3 prior to E. coli administration in mice reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages. When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR3 selectively reduces the amount of the eicosanoids PGD2 , PGE2 , PGF2α , and TXB2 in the exudate.
References
1. Serhan, C.N. Novel pro-
2. Dalli, K.J., Sanger, J.M., Rodriguez, A.R., et al. Identification and actions of a novel third maresin conjugate in tissue regeneration: MCTR3 PLoS One 11(2),e0149319(2016).
3. Dalli, J., Vlasakov, I., Riley, I.R., et al. Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages Proc. Natl. Acad. Sci. USA 113(43),12232-12237(2016).
MCTR3 Preparation Products And Raw materials
Raw materials
Preparation Products
MCTR3 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23960 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7979 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8735 | 58 |