AL 8697
- CAS No.
- 1057394-06-5
- Chemical Name:
- AL 8697
- Synonyms
- AL 8697;inhibit,AL 8697,AL8697,p38 MAPK,AL-8697,Autophagy,Inhibitor;3-[3-(tert-Butyl)-6,8-difluoro-[1,2,4]triazolo[4,3-a]pyridin-7-yl]-N-cyclopropyl-5-fluoro-4-methylbenzamide;N-Cyclopropyl-3-[3-(1,1-dimethylethyl)-6,8-difluoro-1,2,4-triazolo[4,3-a]pyridin-7-yl]-5-fluoro-4-methylbenzamide;Benzamide, N-cyclopropyl-3-[3-(1,1-dimethylethyl)-6,8-difluoro-1,2,4-triazolo[4,3-a]pyridin-7-yl]-5-fluoro-4-methyl-
- CBNumber:
- CB04721556
- Molecular Formula:
- C21H21F3N4O
- Molecular Weight:
- 402.41
- MDL Number:
- MOL File:
- 1057394-06-5.mol
AL 8697 price More Price(6)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Tocris | 4753 | AL8697 ≥98%(HPLC) | 1057394-06-5 | 10 | $265 | 2021-12-16 | Buy |
Tocris | 4753 | AL8697 ≥98%(HPLC) | 1057394-06-5 | 50 | $988 | 2021-12-16 | Buy |
TRC | A575818 | AL8697 | 1057394-06-5 | 2.5mg | $360 | 2021-12-16 | Buy |
Usbiological | 254578 | AL 8697 | 1057394-06-5 | 10mg | $545 | 2021-12-16 | Buy |
ApexBio Technology | B7784 | AL8697 | 1057394-06-5 | 5mg | $614 | 2021-12-16 | Buy |
AL 8697 Chemical Properties,Uses,Production
Uses
AL 8697 is a selective and potent p38α inibitor and has potential use as antiinflammatory agents against diseases such as arthritis.
Biological Activity
al8697 is a selective p38 mapk(mitogen-activated protein kinase) inhibitor, which is also named p38 α inhibitor. it has the function of inhibiting the activity of p38 mapk.[1]mitogen activated protein kinases (mapk) are a group of signaling molecules that appear to play important roles in inflammatory processes. the p38 mapk is one of the best described mapk cascades. the p38 mapk plays a key role in both the synthesis and the signalling of pro-inflammatory cytokines such as tnfa and il-6 by monocyte/macrophages. the p38 mapk are involved in the up-regulation of tnf production by murine macrophages.it has high activity in cardiovascular cells under a variety of cellular stresses. in cardiovascular disease, the p38 mapk signaling pathways are activated.[2,3]al8697 function by the inhibition of p38 mapk. it regulates a variety of cell activities related with p38 mapk.in a rat adjuvant-induced arthritis model, al8697 exhibited a good anti-inflammatory effect and induced leukocytosis and increased total plasma cholesterol, these properties were evidently at 10 mg/kg. in addition, al8697 partially restored the platelet count. the complex profile for al8697 in rat aia (adjuvant-induced arthritis) is not observed in human ra (rheumatoid arthritis).[1]
storage
Store at +4°C
References
[1]. balagué c, pont m, prats n, godessart n. profiling of dihydroorotate dehydrogenase, p38 and jak inhibitors in the rat adjuvant-induced arthritis model: a translational study. br j pharmacol. 2012 jun;166(4):1320-32
[2]. ajizian sj, english bk, meals ea.specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma. j infect dis. 1999 apr;179(4):939-44.
[3]. bao w, behm dj, nerurkar ss, ao z, et al. effects of p38 mapk inhibitor on angiotensin ii-dependent hypertension, organ damage, and superoxide anion production. j cardiovasc pharmacol. 2007 jun;49(6):362-8.
AL 8697 Preparation Products And Raw materials
Raw materials
Preparation Products
AL 8697 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
Changzhou Chenhong Biotechnology Co., Ltd. | 0519-85788828 13775037613 | sales@chemrenpharm.com | China | 3600 | 58 |
Guangzhou Younan Technology Co., Ltd | 020-020-82000279 18988968278 | sales@ubiochem.com | China | 4297 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10000 | 58 |