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UPGL00004

UPGL00004 structure

CAS No.: 1890169-95-5

Chemical Name:: UPGL00004

Synonyms: UPGL00004;UPGL00004,UPGL-00004;2-Phenyl-N-(5-(4-((5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)amino)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)acetamide;Benzeneacetamide, N-[5-[4-[[5-[(2-phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]amino]-1-piperidinyl]-1,3,4-thiadiazol-2-yl]-

CBNumber:: CB04800860

Molecular Formula:: C25H26N8O2S2

Molecular Weight:: 534.66

MDL Number:

MOL File:: 1890169-95-5.mol

Last updated:2024-07-02 08:54:58

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UPGL00004 Properties

Density	1.460±0.06 g/cm3(Predicted)
pka	9.23±0.50(Predicted)
form	Solid
color	Off-white to gray

UPGL00004 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0068007	UPGL00004 ≥98.0%	1890169-95-5	5mg	$250	2021-12-16	Buy
ChemScene	CS-0068007	UPGL00004 ≥98.0%	1890169-95-5	50mg	$1200	2021-12-16	Buy
Biorbyt Ltd	orb573368	UPGL00004 >98%	1890169-95-5	100mg	$1208.7	2021-12-16	Buy
Biorbyt Ltd	orb573368	UPGL00004 >98%	1890169-95-5	250mg	$2395.3	2021-12-16	Buy
Biorbyt Ltd	orb573368	UPGL00004 >98%	1890169-95-5	1g	$4766.8	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0068007	5mg	$250	Buy
CS-0068007	50mg	$1200	Buy
orb573368	100mg	$1208.7	Buy
orb573368	250mg	$2395.3	Buy
orb573368	1g	$4766.8	Buy

UPGL00004 Chemical Properties,Uses,Production

Biological Activity

UPGL00004 is a potent glutaminase C (GAC) inhibitor with IC50 of 29 nM, more selective for GAC than GLS2.

in vitro

Administration of UPGL00004 in combination with the anti-VEGF antibody bevacizumab effectively inhibited triple-negative breast cancer cell growth and tumor growth.

in vivo

Administration of UPGL00004 in combination with the anti-VEGF antibody bevacizumab inhibited tumor growth in a human xenograft model of breast cancer.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 29 nM

Target	Value
glutaminase C (Cell-free assay)

UPGL00004 Preparation Products And Raw materials

Raw materials

Preparation Products

UPGL00004 Suppliers

Global( 40)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10522	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hebei Miaoyin Technology Co.,Ltd	+86-17367732028 +86-17367732028	kathy@hbyinsheng.com	China	3582	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4694	58
Wuhan Acumen Bio-Technology Co.,ltd	027-027-16602739303 16602739303	673003916@qq.com	China	3237	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4264	55
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Hebei Miaoyin Technology Co.,Ltd	58
Aladdin Scientific	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
Wuhan Acumen Bio-Technology Co.,ltd	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
BOC Sciences	65

UPGL00004 UPGL00004,UPGL-00004 Benzeneacetamide, N-[5-[4-[[5-[(2-phenylacetyl)amino]-1,3,4-thiadiazol-2-yl]amino]-1-piperidinyl]-1,3,4-thiadiazol-2-yl]- 2-Phenyl-N-(5-(4-((5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)amino)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)acetamide 1890169-95-5