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2-Amino-5-methylpyridine

2-Amino-5-methylpyridine structure

CAS No.: 1603-41-4

Chemical Name:: 2-Amino-5-methylpyridine

Synonyms: 5-METHYLPYRIDIN-2-AMINE;NSC 1489;NSC 96444;AKOS 91156;6-amino-3-picolin;6-AMINO-3-PICOLINE;2-AMINO-5-PICOLINE;TIMTEC-BB SBB004353;3-Picoline, 6-amino-;2-Amino-5-methylpyri

CBNumber:: CB0485858

Molecular Formula:: C6H8N2

Molecular Weight:: 108.14

MDL Number:: MFCD00006328

MOL File:: 1603-41-4.mol

MSDS File:: SDS

Last updated:2024-11-26 11:58:42

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2-Amino-5-methylpyridine Properties

Melting point	76-77 °C(lit.)
Boiling point	227 °C(lit.)
Density	227
vapor pressure	3.706Pa at 25℃
refractive index	1,524-1,528
Flash point	118°C
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	1000g/l
form	Crystalline Powder, Crystals or Flakes
pka	pK1: 7.22(+1) (25°C)
color	White to light yellow
Sensitive	Hygroscopic
BRN	107050
InChIKey	CMBSSVKZOPZBKW-UHFFFAOYSA-N
LogP	1.08
CAS DataBase Reference	1603-41-4(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	8UM54T43WT
NIST Chemistry Reference	2-Pyridinamine, 5-methyl-(1603-41-4)
EPA Substance Registry System	6-Amino-3-picoline (1603-41-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301+H311-H315-H319-H335

Precautionary statements

P280-P301+P310+P330-P302+P352+P312-P305+P351+P338

Hazard Codes

T,Xi

Risk Statements

23/24/25-36/37/38-25

Safety Statements

26-36/37/39-45-37/39-28A

RIDADR

UN 2811 6.1/PG 2

WGK Germany

RTECS

TJ5141000

Hazard Note

Irritant

TSCA

Yes

HazardClass

6.1

PackingGroup

III

HS Code

29333999

Toxicity

LD50 orl-rat: 200 mg/kg 85JCAE -,841,86

NFPA 704

	1
3		0

2-Amino-5-methylpyridine price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A75684	2-Amino-5-methylpyridine 99%	1603-41-4	10g	$30.12	2024-03-01	Buy
Sigma-Aldrich	A75684	2-Amino-5-methylpyridine 99%	1603-41-4	50g	$58.32	2024-03-01	Buy
TCI Chemical	A0732	2-Amino-5-methylpyridine >98.0%(GC)(T)	1603-41-4	25g	$46	2024-03-01	Buy
TCI Chemical	A0732	2-Amino-5-methylpyridine >98.0%(GC)(T)	1603-41-4	500g	$489	2024-03-01	Buy
Alfa Aesar	A13330	2-Amino-5-methylpyridine, 99%	1603-41-4	50g	$70.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
A75684	10g	$30.12	Buy
A75684	50g	$58.32	Buy
A0732	25g	$46	Buy
A0732	500g	$489	Buy
A13330	50g	$70.65	Buy

2-Amino-5-methylpyridine Chemical Properties,Uses,Production

Chemical Properties

light yellow crystalline flakes

Uses

2-Amino-5-methylpyridine is used as an intermediate in the pharmaceutical industry for the manufacture of Avosentan (used in diabetic nephropathy), Pirfenidone (anti-inflammatory, anti-oxidant and antifibrotic agent) and Zolpidem (sedative/ hypnotics). It is also used for the manufacture of Fluazuron, which is a pesticide, and for commercial purposes.

Uses

Intermediate.

Safety Profile

Poison by ingestion,subcutaneous, and skin contact routes. When heated todecomposition it emits toxic vapors of NOx.

Synthesis

2.2 g (0.377 mol) of trimethylamine are condensed at -10 °C. and added at -5 °C. to a solution of 10.03 g (0.092 mol) of 3-methyl-pyridine 1-oxide in 120 ml of methylene chloride. At this temperature, 7.9 (0.11 mol) of thionyl chloride in 15 ml of methylene chloride is added dropwise in 30 minutes. The temperature during this process is kept below 0 °C. The resulting yellow solution is allowed to thaw and is stirred overnight at room temperature. The solvent is removed in vacuo 35 ml of a 48% strength hydrogen bromide solution and then added. The water is distilled off, and the mixture is then heated to 210 °C. A 48% strength hydrogen bromide solution is continuously added dropwise, and water is distilled. After 8 hours, the reaction is completed according to thin-layer chromatography. The mixture is allowed to cool and is adjusted to pH 9 using a dilute sodium hydroxide solution. The mixture is then extracted four times using ethyl acetate. After filtration, the combined extracts are dried over sodium sulphate and concentrated on the rotary evaporator. 8 g (80.5% of theory) of 2-amino-5-methylpyridine are obtained.

Purification Methods

Crystallise it from acetone. [Beilstein 22/9 V 289.]

2-Amino-5-methylpyridine Preparation Products And Raw materials

Raw materials

5-Methylpyridine Trimethylamine 3-Picoline-N-oxide Hydrogen bromide Trimethylamine hydrochloride

Chloromethane

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Preparation Products

6-(2,2,2-TRIFLUOROETHOXY)NICOTINIC ACID 2-Hydroxy-5-methyl-3-nitropyridine (6-AMINO-3-PYRIDINYL)METHANOL Ethyl 6-aminonicotinate Nalidixic acid

2-AMINO-3-NITRO-5-PICOLINE 6-Fluoronicotinic acid 2-ACETAMIDO-5-PYRIDINECARBOXYLIC ACID 3-AMINO-2-CHLORO-5-PICOLINE 2-Fluoro-5-methylpyridine

TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL]CARBAMATE 6-AMINONICOTINOHYDRAZIDE 6-CHLOROPYRIDINE-3,4-DICARBOXYLIC ACID (5-METHOXYMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER Methyl 6-aminonicotinate

METHYL 6-[(TERT-BUTOXYCARBONYL)AMINO]NICOTINATE 2,3-Dichloro-5-(trifluoromethyl)pyridine 2-Amino-3-bromo-5-methylpyridine 2-ACETYLAMINO-3-BROMO-5-METHYLPYRIDINE 2-ACETAMIDO-5-PICOLINE

2-BROMO-3-NITRO-5-METHYL PYRIDINE 2-Chloro-5-methylpyridine 2-Chloro-5-methyl-3-nitropyridine 6-Aminonicotinic acid 2-FLUOROPYRIDINE-5-CARBONYL CHLORIDE

METHYL 6-(ACETYLAMINO)NICOTINATE

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2-Amino-5-methylpyridine Suppliers

Global( 657)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Terma Medicare India Pvt.,Ltd	+8613916485955	shivshanghai@yahoo.com	India	150	58
Shanghai Yongzeng Technology Co.,Ltd	+86-021-65281118 +86-13818947575	sales@yongzchem.com	China	137	58
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8810	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5892	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883 +86-16264648883	niki@zlchemi.com	China	1056	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Jiangsu Zhongbang Pharmaceutical Co., Ltd.	025-87151996	zbsales@chinaredsun.com	CHINA	32	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9206	55

Supplier	Advantage
Terma Medicare India Pvt.,Ltd	58
Shanghai Yongzeng Technology Co.,Ltd	58
Hebei Weibang Biotechnology Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Jiangsu Zhongbang Pharmaceutical Co., Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55

View Lastest Price from 2-Amino-5-methylpyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-28	2-Amino-5-methylpyridine 1603-41-4	US $50.00 / kg	1kg	99	5000	Hebei Zhuanglai Chemical Trading Co Ltd
2024-11-27	2-Amino-5-methylpyridine 1603-41-4	US $0.00 / Kg/Drum	1KG	99%min	10 TONS	WUHAN FORTUNA CHEMICAL CO., LTD
2024-11-20	2-Amino-5-methylpyridine 1603-41-4	US $19.00 / ASSAYS	100ASSAYS	99%	100 mt	Hebei Weibang Biotechnology Co., Ltd

2-Amino-5-methylpyridine
1603-41-4
US $50.00 / kg
99
Hebei Zhuanglai Chemical Trading Co Ltd

2-Amino-5-methylpyridine
1603-41-4
US $0.00 / Kg/Drum
99%min
WUHAN FORTUNA CHEMICAL CO., LTD

2-Amino-5-methylpyridine
1603-41-4
US $19.00 / ASSAYS
99%
Hebei Weibang Biotechnology Co., Ltd

2-Amino-5-methylpyridine Spectrum

2-Amino-5-methylpyridine(1603-41-4)MS 2-Amino-5-methylpyridine(1603-41-4)¹HNMR 2-Amino-5-methylpyridine(1603-41-4)¹³CNMR 2-Amino-5-methylpyridine(1603-41-4)IR1 2-Amino-5-methylpyridine(1603-41-4)IR2 2-Amino-5-methylpyridine(1603-41-4)Raman

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TIMTEC-BB SBB004353 2-Pyridinamine,5-methyl- 3-Picoline, 6-amino- 2-AMINO-5-PICOLINE 5-METHYL-2-PYRIDYLAMINE 6-AMINO-3-PICOLINE 6-AMINO-BETA-PICOLINE AKOS 91156 2-AMINO-5-METHYLPYRIDINE 98% 2-AMINO-5-METHYLPYRIDINE, PHARMA 2-Amino-5-picoline;2-Amino-5-methylpyridine; 5-Methylpyridin-2-amine 2-Pyridinamine,5-methyl-(9CI) 2-AMINO-5-METHYLPYRIDINE (2-AMINO-5-PICOLINE) 2-AMINO-5-METHYL PYRIDINE 5-METHYLPYRIDIN-2-YLAMINE 2-Amino-5-methylpyridine ,99% 5-Methyl-2(1H)-pyridineimine 2-Amino-5-picoline,99% 2-Amino-5-Picoline(2-Amino-5-MethylPyridine 5-Methyl-2-aminopyridine 5-methyl-2-pyridinamin 5-Methyl-2-pyridinamine 5-Methyl-2-pyridylamine dine 6-Amino-3-picoline 2-Amino-5-picoline 5-Methyl-2-pyridylamine 6-Amino-3-picoline, 5-Methylpyridin-2-amine 2-AMino-5-picoline, 99% 10GR 6-amino-3-picolin Pyridine, 2-amino-5-methyl 2-AMINO-5-METHYLPYRIDINE NSC 1489 NSC 96444 6-Amino-3-picoline 2-Amino-5-picoline 2-Amino-5-methylpyri 2-Amio-5-Methylpyridine Perfenidone Impurity 2 2-Amino-5-methylpyridine > 5-Methyl-2-pyridylamin Pirfenidone Impurity 1（Pirfenidone EP Impurity A） 5-METHYLPYRIDIN-2-AMINE 2-Amino-5-methylpyridine with high quality Pirfenidone Related Compound A (15 mg) (5-Methylpyridin-2-amine) 2-Amino-5-Methylpyridine 98.5% For Synthesis Pirfenidone EP Impurity A 5-methylpyridin-2-amine 1603-41-4 1503-41-4 1603-34-1 10603-41-4 504-29-3 Building Blocks C6 Heterocyclic Building Blocks Pyridines Building Blocks C6 Chemical Synthesis Heterocyclic Building Blocks Heterocycle-Pyridine series amine Aromatics