4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
- CAS No.
- 72811-73-5
- Chemical Name:
- 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
- Synonyms
- BM 960102;Torsemide Imp B;TORSEMIDE EP IMP B;4-(3'-Methylphenyl)a;TorseMide IMpurity B;SPECS AJ-333/25006115;Torasemide intermediate;Torsemide EP Impurity B;Torasemide EP Impurity B;Torasemide impurity B (EP)
- CBNumber:
- CB0486466
- Molecular Formula:
- C12H13N3O2S
- Molecular Weight:
- 263.32
- MDL Number:
- MFCD00661332
- MOL File:
- 72811-73-5.mol
Melting point | 162-164?C |
---|---|
Boiling point | 475.8±55.0 °C(Predicted) |
Density | 1.357±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 9.53±0.60(Predicted) |
color | White to Off-White |
BRN | 5438165 |
InChIKey | ZXPCUGWAKUIOOF-UHFFFAOYSA-N |
CAS DataBase Reference | 72811-73-5(CAS DataBase Reference) |
FDA UNII | 7GN70NEN27 |
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide price More Price(22)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 1672315 | Torsemide Related Compound A United States Pharmacopeia (USP) Reference Standard | 72811-73-5 | 75mg | $1630 | 2024-03-01 | Buy |
Sigma-Aldrich | PHR3145 | Torsemide Related Compound A pharmaceutical secondary standard, certified reference material | 72811-73-5 | 150MG | $466 | 2022-05-15 | Buy |
TCI Chemical | T3007 | 4-(m-Tolylamino)pyridine-3-sulfonamide >98.0%(HPLC)(T) | 72811-73-5 | 5g | $169 | 2024-03-01 | Buy |
TCI Chemical | T3007 | 4-(m-Tolylamino)pyridine-3-sulfonamide >98.0%(HPLC)(T) | 72811-73-5 | 25g | $834 | 2021-12-16 | Buy |
TRC | M320675 | 4-[(3-Methylphenyl)amino]-3-pyridinesulfonamide | 72811-73-5 | 5g | $300 | 2021-12-16 | Buy |
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Chemical Properties,Uses,Production
Chemical Properties
White to Off-White Solid
Uses
Torasemide intermediate.
Synthesis
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide is prepared by the reaction of 4-Chloropyridine-3-sulfonamide hydrochloride and 3-Methylaniline. The specific synthesis steps are as follows:
EXAMPLE 1; Preparation of 4-(3-methylphenyl)aminopyridine-sulfonamide; 2L three-neck flask, equipped with a mechanical stirrer, thermometer and condenser, was charged with water (500 ml) and 4-chloro-3- pyridinesulfonamide hydrochloride (100g, 0.44 mol). To this suspension was added m-toluidine (49.2 ml, 0.46 mol) at room temperature. The reaction mixture was heated to 90°C for a minimum period of 3 h. The progress of the reaction was followed by HPLC. After completion, the mixture was cooled to room temperature. The pH of the reaction was then adjusted carefully to pH 7-8 with sat. NaHC03 (ca. 1.1 l). The product was precipitated out and isolated by vacuum filtration as beige solid (126.2 g wet weight). The product was then dissolved in MeOH (1.0 l) at room temperature and charged with Darco KB (25g). The solution was refluxed for 0.5 h and then filtered through a patch of celite to remove Darco KB, while still hot, and rinsed with hot MeOH (200 ML). The filtrate was then charged with water (1.2 l) and stirred for a minimum of 1 h at room temperature. The product, which had precipitated out, was isolated by vacuum filtration to obtain a solid 106.3 g (92percent wet weight =>99.8percent purity a/a). 1H NMR (d6-DMSO) ; 2.30 (s, 3H), 7.00-7. 15 (m. 5H), 7.32 (m, 1H), 7.75 (brs, 1.5H), 8.05 (brs, 0.5H), 8.25 (d, 1H), 8.68 (s, 1H).
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | sales@amoychem.com | China | 6383 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17365 | 58 |
Hebei Zhanyao Biotechnology Co. Ltd | 15369953316 +8615369953316 | admin@zhanyaobio.com | China | 2123 | 58 |
View Lastest Price from 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-17 | 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
72811-73-5
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | ||
2021-11-19 | 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
72811-73-5
|
US $10.00 / Kg/Bag | 1Kg/Bag | 99% | 20 Tons | Hebei Zhanyao Biotechnology Co. Ltd | ||
2021-08-12 | 4-(3"-Methylphenyl)amino-3-pyridinesulfonamide
72811-73-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
- 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
72811-73-5
- US $1.10 / g
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
- 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
72811-73-5
- US $10.00 / Kg/Bag
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
- 4-(3"-Methylphenyl)amino-3-pyridinesulfonamide
72811-73-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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