ChemicalBook >> CAS DataBase List >>4-(3'-Methylphenyl)amino-3-pyridinesulfonamide

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide

CAS No.
72811-73-5
Chemical Name:
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
Synonyms
BM 960102;Torsemide Imp B;TORSEMIDE EP IMP B;4-(3'-Methylphenyl)a;TorseMide IMpurity B;SPECS AJ-333/25006115;Torasemide intermediate;Torsemide EP Impurity B;Torasemide EP Impurity B;Torasemide impurity B (EP)
CBNumber:
CB0486466
Molecular Formula:
C12H13N3O2S
Molecular Weight:
263.32
MDL Number:
MFCD00661332
MOL File:
72811-73-5.mol
Last updated:2024-06-04 19:18:49

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Properties

Melting point 162-164?C
Boiling point 475.8±55.0 °C(Predicted)
Density 1.357±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka 9.53±0.60(Predicted)
color White to Off-White
BRN 5438165
InChIKey ZXPCUGWAKUIOOF-UHFFFAOYSA-N
CAS DataBase Reference 72811-73-5(CAS DataBase Reference)
FDA UNII 7GN70NEN27

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P305+P351+P338
Hazard Codes  Xi
Risk Statements  36
Safety Statements  26
HS Code  2935909550

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1672315 Torsemide Related Compound A United States Pharmacopeia (USP) Reference Standard 72811-73-5 75mg $1630 2024-03-01 Buy
Sigma-Aldrich PHR3145 Torsemide Related Compound A pharmaceutical secondary standard, certified reference material 72811-73-5 150MG $466 2022-05-15 Buy
TCI Chemical T3007 4-(m-Tolylamino)pyridine-3-sulfonamide >98.0%(HPLC)(T) 72811-73-5 5g $169 2024-03-01 Buy
TCI Chemical T3007 4-(m-Tolylamino)pyridine-3-sulfonamide >98.0%(HPLC)(T) 72811-73-5 25g $834 2021-12-16 Buy
TRC M320675 4-[(3-Methylphenyl)amino]-3-pyridinesulfonamide 72811-73-5 5g $300 2021-12-16 Buy
Product number Packaging Price Buy
1672315 75mg $1630 Buy
PHR3145 150MG $466 Buy
T3007 5g $169 Buy
T3007 25g $834 Buy
M320675 5g $300 Buy

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Solid

Uses

Torasemide intermediate.

Synthesis

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide is prepared by the reaction of 4-Chloropyridine-3-sulfonamide hydrochloride and 3-Methylaniline. The specific synthesis steps are as follows:
EXAMPLE 1; Preparation of 4-(3-methylphenyl)aminopyridine-sulfonamide; 2L three-neck flask, equipped with a mechanical stirrer, thermometer and condenser, was charged with water (500 ml) and 4-chloro-3- pyridinesulfonamide hydrochloride (100g, 0.44 mol). To this suspension was added m-toluidine (49.2 ml, 0.46 mol) at room temperature. The reaction mixture was heated to 90°C for a minimum period of 3 h. The progress of the reaction was followed by HPLC. After completion, the mixture was cooled to room temperature. The pH of the reaction was then adjusted carefully to pH 7-8 with sat. NaHC03 (ca. 1.1 l). The product was precipitated out and isolated by vacuum filtration as beige solid (126.2 g wet weight). The product was then dissolved in MeOH (1.0 l) at room temperature and charged with Darco KB (25g). The solution was refluxed for 0.5 h and then filtered through a patch of celite to remove Darco KB, while still hot, and rinsed with hot MeOH (200 ML). The filtrate was then charged with water (1.2 l) and stirred for a minimum of 1 h at room temperature. The product, which had precipitated out, was isolated by vacuum filtration to obtain a solid 106.3 g (92percent wet weight =>99.8percent purity a/a). 1H NMR (d6-DMSO) ; 2.30 (s, 3H), 7.00-7. 15 (m. 5H), 7.32 (m, 1H), 7.75 (brs, 1.5H), 8.05 (brs, 0.5H), 8.25 (d, 1H), 8.68 (s, 1H).
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide synthesis

777854-85-0
108-44-1
72811-73-5
Synthesis of 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide from 4-Chloro-3-pyridinesulfonamide hydrochloride,98% and m-Toluidine

4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Preparation Products And Raw materials

Global( 319)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806 sales@capot.com China 29791 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29881 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28172 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845 sales@amoychem.com China 6383 58
Standardpharm Co. Ltd.
86-714-3992388 overseasales1@yongstandards.com United States 14332 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63687 58
SIMAGCHEM CORP
+86-13806087780 sale@simagchem.com China 17365 58
Hebei Zhanyao Biotechnology Co. Ltd
15369953316 +8615369953316 admin@zhanyaobio.com China 2123 58

View Lastest Price from 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide pictures 2024-04-17 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
72811-73-5
US $1.10 / g 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
4-(3'-Methylphenyl)amino-3-pyridinesulfonamide pictures 2021-11-19 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide
72811-73-5
US $10.00 / Kg/Bag 1Kg/Bag 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd
4-(3 2021-08-12 4-(3"-Methylphenyl)amino-3-pyridinesulfonamide
72811-73-5
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
4-(-3-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE 4-(3'-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE 3-SULFONAMIDO-4-(3-METHYLANILINO)-PYRIDINE SPECS AJ-333/25006115 4-(3-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE (SMPAP) 4-[3-Methyl phenyl] amino-3-pyridine sulphonamide Torasemide intermediate [4-(3-Methylphenyl)amino]pyrid 4-(3-methylphenyl)amino-3-pyridine sulfonamide (intermediate of torasemide) 4-(3-methylphenylamino) Pyridine-3-sulfonamide [4-3-Methylphenyl)amino]pyridine-3-sulphonamide 4-(3-METHYLPHENYL)AMINO-3-PYRIDINESULFONAMIDE 98% 4-(3'-Methylphenyl)a TorseMide Related CoMpound A BM 960102 4-(M-TolylaMino)pyridine-3-sulfonaMide TorseMide IMpurity B Standard for Torasemide Impurity Torasemide Impurity 2(Torasemide EP Impurity B) Torasemide EP Impurity B Torasemide impurity B (EP) 4-[(3-Methylphenyl)amino]-pyridin-3-sulfonamide Torsemide USP Related Compound A Torasemi Impurity B Standard 4[(3-Methyl Phenyl) amino] 3-Pyridine Sulfonamide (Torsamide Intermediate) (72811-73-5) 4-[(3-Methylphenyl)amino]pyridine-3 3-Pyridinesulfonamide, 4-[(3-methylphenyl)amino]- Torsemide EP Impurity B 4-(3-Methylphenyl)amino-3-sulfamoylpyridine 4-(m-Tolylamino)-3-sulfamoylpyridine 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide ISO 9001:2015 REACH Torsemide EP Impurity B/ Torsemide Related Compound A TIANFU-CHEM_high purity of 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide Torsemide Impurity BQ: What is Torsemide Impurity B Q: What is the CAS Number of Torsemide Impurity B Q: What is the storage condition of Torsemide Impurity B Q: What are the applications of Torsemide Impurity B 4-(3-methylanilinopyridine)-3-sulfonamide Torasemide, Anhydrous Impurity B Torasemide, Anhydrous EP Impurity B 4-(3-Methylphenyl)Amino-3-Pyridinesulfonamide (Torsemide Intermediate) Torsemide Imp B 4-(3'-Methylphenyl)amino-3-pyridinesulfonamide TORSEMIDE EP IMP B Torasemide (Torsemide) EP Impurity B (Torasemide (Torsemide) USP Related Compound A) 72811-73-5 C12H13N3O2S Aromatics Intermediates & Fine Chemicals Pharmaceuticals INTERMEDIATESOFTORASEMIDE Pyridines derivates (intermediate of torasemide) Pyridines Torsemide 72811-73-5