PF429242 dihydrochloride
- CAS No.
- 2248666-66-0
- Chemical Name:
- PF429242 dihydrochloride
- Synonyms
- PF 429242-HCl;PF429242,PF-429242 dihydrochloride,PF429242 dihydrochloride,Virus Protease,inhibit,PF 429242,Inhibitor,Fatty Acid Synthase (FASN),PF-429242
- CBNumber:
- CB05419810
- Molecular Formula:
- C25H36ClN3O2
- Molecular Weight:
- 446.03
- MDL Number:
- MOL File:
- 2248666-66-0.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H303-H315-H319-H335-H410-H372 |
| Precautionary statements | P261-P264-P271-P273-P280-P302+P352-P304+P340+P312-P305+P351+P338-P312-P332+P313-P337+P313-P391-P403+P233-P405-P501 |
PF429242 dihydrochloride price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 15140 | PF-429242 (hydrochloride) | 2248666-66-0 | 1mg | $50 | 2024-03-01 | Buy |
| Cayman Chemical | 15140 | PF-429242 (hydrochloride) | 2248666-66-0 | 25mg | $547 | 2024-03-01 | Buy |
| Cayman Chemical | 15140 | PF-429242 (hydrochloride) | 2248666-66-0 | 5mg | $135 | 2024-03-01 | Buy |
| Cayman Chemical | 15140 | PF-429242 (hydrochloride) | 2248666-66-0 | 10mg | $243 | 2024-03-01 | Buy |
| ChemScene | CS-6890 | PF-429242 dihydrochloride 98.08% | 2248666-66-0 | 25mg | $336 | 2021-12-16 | Buy |
PF429242 dihydrochloride Chemical Properties,Uses,Production
Description
PF-429242 is an inhibitor of site-1 protease with an IC50 value of 170 nM for human recombinant site-1 protease. It is selective for site-1 protease over trypsin, elastase, proteinase K, plasmin, kallikren, factor XIa, thrombin, and furin at concentrations up to 100 μM. PF-429242 completely inhibits proteolytic processing and nuclear translocation of sterol regulatory element-binding protein (SREBP) in HepG2 cells at a concentration of 10 μM. It also reduces expression of HMG-CoA synthase and fatty acid synthase (EC50s = 0.3 and 2 μM, respectively) and inhibits cholesterol synthesis (EC50 = 600 nM) in HepG2 cells and reduces cholesterol and fatty acid synthesis in CD-1 mice. PF-429242 inhibits replication of dengue virus serotypes 1-4 in infected HeLa cells. It also reduces growth of T98G, U87-MG, and A172 glioblastoma cells (IC50s = 0.32, 15.2, and 27.6 μM, respectively).
storage
Desiccate at RT
PF429242 dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
PF429242 dihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29786 | 68 |
| Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1841 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |