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CM-675

CM-675 Structure
CM-675 structure
CAS No.
1872466-47-1
Chemical Name:
CM-675
Synonyms
CM-675;CM675,CM 675;Benzamide, N-(2-aminophenyl)-4-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]methyl]-
CBNumber:
CB05540390
Molecular Formula:
C31H32N6O3
Molecular Weight:
536.62
MDL Number:
MFCD32067899
MOL File:
1872466-47-1.mol
Last updated:2024-07-02 08:54:58
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CM-675 Properties

Density 1.29±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 25 mg/mL (46.59 mM; ultrasonic and warming and heat to 60°C)
form Solid
pka 13.23±0.70(Predicted)
color Off-white to gray

CM-675 Chemical Properties,Uses,Production

Biological Activity

CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer's disease[1]. CM-675 (29a) shows a significant time-dependent effect on class I HDAC inhibition, particularly towards HDAC2. For HDAC1, its inhibitory potency also increased significantly (~1 log unit) with the pre-incubation time: 673 nM (30 min), 180 nM (4 hours) and 69 nM (6 hours) [1].

References

[1]. Rabal O, et al. Discovery of in Vivo Chemical Probes for Treating Alzheimer's Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors. ACS Chem Neurosci. 2019 Mar 20;10(3):1765-1782.

CM-675 Preparation Products And Raw materials

Raw materials

Preparation Products

CM-675 Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23963 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 5012 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9274 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 12007 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Aladdin Scientific 		58
TargetMol Chemicals Inc. 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58
RD International Technology Co., Limited 58
Nanjing Shizhou Biology Technology Co.,Ltd 58

CM-675 Spectrum

CM-675(1872466-47-1)1HNMR
CM-675 CM675,CM 675 Benzamide, N-(2-aminophenyl)-4-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]methyl]- 1872466-47-1