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2,5-Dihydroxycinnamic Acid phenethyl ester

2,5-Dihydroxycinnamic Acid phenethyl ester Structure
2,5-Dihydroxycinnamic Acid phenethyl ester structure
CAS No.
179691-97-5
Chemical Name:
2,5-Dihydroxycinnamic Acid phenethyl ester
Synonyms
5-LOX-IN-2;2,5-Dihydroxycinnamic Acid phenethyl ester;(2E)-3-(2,5-dihydroxyphenyl)-2-propenoic acid, 2-phenylethyl ester;2-Propenoic acid, 3-(2,5-dihydroxyphenyl)-, 2-phenylethyl ester, (2E)-
CBNumber:
CB06197863
Molecular Formula:
C17H16O4
Molecular Weight:
284.31
MDL Number:
MOL File:
179691-97-5.mol
Last updated:2024-11-19 15:53:33
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2,5-Dihydroxycinnamic Acid phenethyl ester Properties

Boiling point 515.5±50.0 °C(Predicted)
Density 1.266±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
form A crystalline solid
pka 9.85±0.48(Predicted)
color Off-white to light yellow

2,5-Dihydroxycinnamic Acid phenethyl ester price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AK Scientific 4787CP Phenethyl(E)-3-(2,5-dihydroxyphenyl)prop-2-enoate 179691-97-5 5mg $289 2021-12-16 Buy
AK Scientific 4787CP Phenethyl(E)-3-(2,5-dihydroxyphenyl)prop-2-enoate 179691-97-5 10mg $430 2021-12-16 Buy
AK Scientific 4787CP Phenethyl(E)-3-(2,5-dihydroxyphenyl)prop-2-enoate 179691-97-5 25mg $868 2021-12-16 Buy
Product number Packaging Price Buy
4787CP 5mg $289 Buy
4787CP 10mg $430 Buy
4787CP 25mg $868 Buy

2,5-Dihydroxycinnamic Acid phenethyl ester Chemical Properties,Uses,Production

Description

2,5-Dihydroxycinnamic acid phenethyl ester is an inhibitor of 5-lipoxygenase (5-LO) with an IC50 value of 0.33 μM for inhibition of 5-LO product synthesis in polymorphonuclear leukocytes (PMNLs) stimulated with the sarcoendoplasmic reticulum calcium ATPase (SERCA) inhibitor thapsigargin .1 It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC50 = 16.41 μM) in a cell-free assay. 2,5-Dihydroxycinnamic acid phenethyl ester selectively decreases viability of RCC4 and 786-O cells lacking the Von Hippel-Lindau (VHL) tumor suppressor gene (IC50s = 8 and 34.8 μM, respectively) over cells homozygously expressing VHL (IC50s = 99.6 and >100 μM, respectively). However, it also decreases viability of RCC10 VHL-/- and RCC10 VHL+/+ cells (IC50s = 5.04 and 0.96 μM, respectively). It increases the levels of pro-caspase-3a, LC3B-I, and LC3B-II in RCC4 VHL-/- cells in a concentration-dependent manner.

References

1. Selka, A., Doiron, J.A., Lyons, P.A., et al. Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells Eur. J. Med. Chem. 179,347-357(2019).

2,5-Dihydroxycinnamic Acid phenethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

2,5-Dihydroxycinnamic Acid phenethyl ester Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 7268 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9409 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11217 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24647 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 6813 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11974 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Shanghai Chaolan Chemical Technology Center 58
Shanghai Hongye Biotechnology Co. Ltd 58
DC Chemicals 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
TargetMol Chemicals Inc. 58
Nanjing Tengyi Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

View Lastest Price from 2,5-Dihydroxycinnamic Acid phenethyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-LOX-IN-2 pictures 2024-11-19 5-LOX-IN-2
179691-97-5
 US $52.00-333.00 / mg 99.18% 10g TargetMol Chemicals Inc.
  • 5-LOX-IN-2 pictures
  • 5-LOX-IN-2
    179691-97-5
  • US $52.00-333.00 / mg
  • 99.18%
  • TargetMol Chemicals Inc.
2,5-Dihydroxycinnamic Acid phenethyl ester 2-Propenoic acid, 3-(2,5-dihydroxyphenyl)-, 2-phenylethyl ester, (2E)- 5-LOX-IN-2 (2E)-3-(2,5-dihydroxyphenyl)-2-propenoic acid, 2-phenylethyl ester 179691-97-5