M344
- CAS No.
- 251456-60-7
- Chemical Name:
- M344
- Synonyms
- M344;CS-661;MS 344;M344 (D 237);MS 344, D237;M344 USP/EP/BP;M 344 (enzyme inhibitor);HISTONE DEACETYLASE INHIBITOR III;Histone Deacetylase Inhibitor III(M344);N-HYDROXY-7-(4-DIMETHYLAMINOBENZOYL)AMINOHEPTANAMIDE
- CBNumber:
- CB0673778
- Molecular Formula:
- C16H25N3O3
- Molecular Weight:
- 307.39
- MDL Number:
- MFCD03453554
- MOL File:
- 251456-60-7.mol
- MSDS File:
- SDS
| Melting point | 161℃ |
|---|---|
| Density | 1.137±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| pka | 9.48±0.20(Predicted) |
| form | White solid |
| color | white to beige |
| Sensitive | Light Sensitive |
| CAS DataBase Reference | 251456-60-7 |
| FDA UNII | J8W4VF5ZEJ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P302+P352-P305+P351+P338-P321-P405-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2928.00.2500 | |||||||||
| NFPA 704 |
|
M344 price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M5820 | M344 ≥98% (HPLC), powder | 251456-60-7 | 1mg | $229 | 2024-03-01 | Buy |
| Sigma-Aldrich | 382149 | Histone Deacetylase Inhibitor III | 251456-60-7 | 1mg | $187 | 2024-03-01 | Buy |
| TCI Chemical | D4188 | 4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide >97.0%(HPLC) | 251456-60-7 | 20mg | $263 | 2024-03-01 | Buy |
| TCI Chemical | D4188 | 4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide >97.0%(HPLC) | 251456-60-7 | 100mg | $870 | 2024-03-01 | Buy |
| Alfa Aesar | J64940 | Histone Deacetylase Inhibitor III | 251456-60-7 | 10mg | $228 | 2021-12-16 | Buy |
M344 Chemical Properties,Uses,Production
Uses
Histone deacetylase inhibitor III. A cell-permeable amide analog of Trichostatin A that potently inhibits HDACs.
Uses
M 344 is an inhibitor of histone deacetylases (HDACs), inhibiting maize HDAC (IC50 = 100 nM) as well as human HDAC1 (IC50 = 46 nM). It shows a three-fold selectivity for inhibition of HDAC6 over HDAC1. M 344 enhances the sensitivity of human squamous carcinoma cells to radiation and promotes cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells (ED50 = 2.3 μM).
Definition
ChEBI: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide is a benzamide resulting from the formal condensation of the carboxy group of 4-(dimethylamino)benzoic acid with the amino group of 7-amino-N-hydroxyheptanamide. It is a potent inhibitor of histone deacetylases and induces cell cycle arrest and apoptosis in several human cancer cell lines. It has a role as an apoptosis inducer, an antineoplastic agent and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is a member of benzamides, a hydroxamic acid, a secondary carboxamide and a tertiary amino compound.
General Description
A cell-permeable amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylases (IC50 = 40 nM for rat liver HDAC and IC50 = 100 nM for maize HD). Induces differentiation and inhibits proliferation (~2 μM) of murine erythroleukemia cells.
Biological Activity
Histone deacetylase inhibitor (IC 50 = 100 nM). Induces terminal cell differentiation and causes an increase in hyperacetylated histone H4. Antiproliferative agent; suppresses the growth of human endometrial and ovarian cancer cells by inducing cell cycle arrest and apoptosis.
Biochem/physiol Actions
Cell permeable: yes
References
[1]. jung m, brosch g , kolle d, et al. amide analogues of trichostatin a as inhibitors of histone deacetylase and inducers of terminal cell differentiation. journal of medicinal chemistry, 1999, 42 (22): 4669-4679.
[2]. yeung a, bhargava rk, ahn, r, et al. hdac inhibitor m344 suppresses mcf-7 breast cancer cell proliferation. biomedicine & pharmacotherapy, 2012, 66 (3): 232-236.
[3]. furchert se, lanvers-kaminsky c , jurgens h , et al. inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood. international journal of cancer, 2007, 120 (8): 1787-1794.
[4]. ying h, zhang yh , zhou x , et al. selective histonedeacetylase inhibitor m344 intervenes in hiv-1 latency through increasing histone acetylation and activation of nf-kappab. plos one, 2012, 7 (11): e48832.
M344 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29811 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22883 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
