Ac-DEVD-CMK
- CAS No.
- 285570-60-7
- Chemical Name:
- Ac-DEVD-CMK
- Synonyms
- AC-DEVD-CMK;AC-ASP-GLU-VAL-ASP-CMK;CASPASE-3 INHIBITOR III;AC-ASP-GLU-VAL-ASP-CMK: AC-DEVD-CMK;Ac-Asp-Glu-Val-Asp-chloromethylketone;CASPASE-3 INHIBITOR III ; AC-ASP-GLU-VAL-ASP-CMK;Ac-Asp-Glu-Val-Asp-chloromethylketone trifluoroacetate salt;L-Valinamide, N-acetyl-L-α-aspartyl-L-α-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-;N-Acetyl-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-L-valinamide
- CBNumber:
- CB0725327
- Molecular Formula:
- C21H31ClN4O11
- Molecular Weight:
- 550.94
- MDL Number:
- MFCD01323001
- MOL File:
- 285570-60-7.mol
- MSDS File:
- SDS
Ac-DEVD-CMK price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J64442 | Caspase-3 Inhibitor III | 285570-60-7 | 1mg | $114 | 2023-06-20 | Buy |
| Alfa Aesar | J64442 | Caspase-3 Inhibitor III | 285570-60-7 | 5mg | $333 | 2021-12-16 | Buy |
| Cayman Chemical | 14465 | Ac-DEVD-CMK ≥98% | 285570-60-7 | 1mg | $65 | 2021-12-16 | Buy |
| Cayman Chemical | 14465 | Ac-DEVD-CMK ≥98% | 285570-60-7 | 5mg | $293 | 2021-12-16 | Buy |
| ApexBio Technology | C5528 | Ac-DEVD-CMK | 285570-60-7 | 1mg | $90 | 2021-12-16 | Buy |
Ac-DEVD-CMK Chemical Properties,Uses,Production
Uses
A potent, cell-permeable, and irreversible inhibitor of caspase-3; also inhibits caspases -6, -7, -8, and -10. Commonly used at concentrations up to 100 M to examine the role of caspase-3-dependent apoptosis
Uses
Ac-DEVD-CMK is a cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, -7, -8, and -10. It is commonly used at concentrations up to 100 μM to examine the role of caspase-3-dependent apoptosis in biological systems.
Biological Activity
ac-devd-cmk is a cell-permeable and irreversible caspase-3 inhibitor [1][2][3].apoptosis is a process of programmed cell death that occurs in multicellular organisms. caspase are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. caspase activation is a major event in apoptosis. caspase-3 cleaves and activates caspases 6 and 7, and is processed and activated by caspases 8, 9, and 10 [1][2][3].ac-devd-cmk (ac-asp-glu-val-asp-ch2cl) is a cell-permeable, irreversible and specific caspase-3 inhibitor. in coronary occlusion/reperfusion rat isolated hearts, ac-devd-cmk reduced infarct size (the percentage of infarction 27.8+3.3% vs control 38.5+2.6%), suggesting that caspase inhibition during early reperfusion protected myocardium against lethal reperfusion injury [1]. in bl41 cells, ac-devd-cmk partially inhibited mn2+-induced apoptosis and parp cleavage, and partially blocked b cell death by 37% even at 100 μm [2]. ac-devd-cmk significantly blocked neurotoxicity at 24 hr after 1 hr of sin-1 exposure and also protected against neurotoxicity at 24 hr after 90 min of zinc (75 μm) exposure. ac-devd-cmk completely blocked sin-1-induced activation of caspase-3 [3].
References
[1]. mocanu mm, baxter gf, yellon dm. caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury. br j pharmacol. 2000 may;130(2):197-200.
[2]. schrantz n, blanchard da, mitenne f, et al. manganese induces apoptosis of human b cells: caspase-dependent cell death blocked by bcl-2. cell death differ. 1999 may;6(5):445-53.
[3]. zhang y, wang h, li j, et al. peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation. j neurosci. 2004 nov 24;24(47):10616-27.
Ac-DEVD-CMK Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Nanjing TGpeptide | +86-13347807150 +86-13347807150 | support@tgpeptide.com | China | 3279 | 58 |
| Zhejiang Hangyu API Co., Ltd | +8617531972939 | anna@api-made.com | China | 2943 | 58 |
| Changsha MOL Changes Biotechnology Co., Ltd. | +8619375158599 | info@molchanges.com | China | 5225 | 58 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9923 | 65 |
| Alabiotech Inc. | 001-619-354-5251 | sales@alabiotech-e.com | United States | 972 | 60 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 7267 | 58 |
| Nanjing Peptide Biotech Ltd. | 025-025-58361106-805-805 13082558573 | liugang@njpeptide.com | China | 9980 | 55 |