Mangostin
- CAS No.
- 6147-11-1
- Chemical Name:
- Mangostin
- Synonyms
- mangostin;NSC 27593;NSC 30552;NSC 139154;MANGOSTINE;Mangosteen;α-Mangosten;a-Mangosten;a-Mangostin;α-mangostin
- CBNumber:
- CB0739500
- Molecular Formula:
- C24H26O6
- Molecular Weight:
- 410.46
- MDL Number:
- MFCD00135200
- MOL File:
- 6147-11-1.mol
- MSDS File:
- SDS
| Melting point | 180-182°C |
|---|---|
| Boiling point | 640.1±55.0 °C(Predicted) |
| Density | 1.265±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | methanol: soluble1mg/mL, clear, very light yellow |
| form | powder |
| pka | 7.22±0.20(Predicted) |
| color | faint yellow to yellow |
| λmax | 346nm(MeOH)(lit.) |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| InChI | InChI=1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3 |
| InChIKey | GNRIZKKCNOBBMO-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C=C(O)C(OC)=C2C/C=C(/C)\C)OC2=C1C(O)=C(C/C=C(/C)\C)C(O)=C2 |
| CAS DataBase Reference | 6147-11-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | U6RIV93RU1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P330+P331+P310 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | ZD6122420 | |||||||||
| HS Code | 29329990 | |||||||||
| Hazardous Substances Data | 6147-11-1(Hazardous Substances Data) | |||||||||
| NFPA 704 |
|
Mangostin price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M3824 | α-Mangostin ≥98% (HPLC) | 6147-11-1 | 10mg | $248 | 2024-03-01 | Buy |
| Sigma-Aldrich | M3824 | α-Mangostin ≥98% (HPLC) | 6147-11-1 | 50mg | $785 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHL89247 | Mangostin phyproof? Reference Substance | 6147-11-1 | 25MG | $317 | 2023-01-07 | Buy |
| Sigma-Aldrich | 07589 | α-Mangostin analytical standard | 6147-11-1 | 25MG | $696 | 2022-05-15 | Buy |
| TCI Chemical | M2793 | α-Mangostin >97.0%(HPLC) | 6147-11-1 | 10mg | $86 | 2024-03-01 | Buy |
Mangostin Chemical Properties,Uses,Production
Description
α-Mangostin (6147-11-1) is a xanthone natural product that has historically been used in traditional folk medicine.1 It is a potent agonist of human STING (Stimulator of Interferon Genes) and also weakly activates mouse STING.2 Induces IFN-β production and repolarizes human monocyte-derived M2 macrophages to M1. Improves insulin secretion and protects INS-1 cells from streptozotocin-induced damage.3 Suppresses the metastasis of human renal carcinoma cells.4 Synergizes with kinase inhibitors in suppression of proliferation of SK-MEL-2 malignant melanoma cells.5
Chemical Properties
Yellow Crystalline Solid
Uses
α-Mangostin has been used:
- to study its protective effect against oxidative stress mediated-retinal cell death
- to study its role as an antigenotoxic agent in DNA protection against oxidative damage
- to understand its anti-bacterial activity against Staphylococcus epidermidis?RP62A
Uses
antifungal, antilarval
Uses
It was isolated from Garcinia mangostana Linn (Guttiferae). It is an anti-inflammatory agent
Definition
ChEBI: Alpha-mangostin is a member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities. It has a role as an antineoplastic agent, an antimicrobial agent, an antioxidant and a plant metabolite. It is a member of xanthones, a member of phenols and an aromatic ether.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biochem/physiol Actions
Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis via the mitochondrial pathway, reduce cell proliferation and inhibit tumorigenesis.
storage
Store at -20°C
References
1) Mohan et al. (2018), An anti-inflammatory molecular mechanism of action of α-mangostin, the major xanthone from the pericarp of Garcinia mangostana: an in silico, in vitro and in vivo approach; Food Funct., 9 3860 2) Zhang et al. (2018), Identification of α-Mangostin as an Agonist of Human STING; Chem. Med. Chem.,?13 2057 3) Lee et al. (2018), Alpha-Mangostin Improves Insulin Secretion and Protects INS-1 Cells from Streptozotocin-induced Damage; J. Mol. Sci., 19 E1484 4) Chen et al. (2017), Alpha-Mangostin Suppresses the Metastasis of Human renal Carcinoma Cells by Targeting MEK/ERK Expression and MMP-9 Transcription Activity; Cell Physiol. Biochem., 44 1460 5) Xia and Sun (2018), Synergistic inhibition of cell proliferation by combined targeting with kinase inhibitors and dietary xanthone is a promising strategy for melanoma treatment; Clin. Exp. Dermatol., 43 149
Mangostin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8810 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12835 | 58 |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | lisa@kingfinertech.com | China | 3010 | 58 |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 423 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3002 | 58 |
| Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 | clara@hbshengyang.com | China | 875 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
View Lastest Price from Mangostin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-12-20 | Fructus monordicae extract | US $0.00 / KG | 1KG | 10%-50% HPLC | 1000KG | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2024-12-20 | Mangostin; α-Mangostin
6147-11-1
|
US $0.00-0.00 / KG | 1KG | 1%-98% HPLC | 1000KG | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2024-12-20 | Mangosteen Peel Extract / Alpha Mangostin
6147-11-1
|
US $180.00 / kg | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co.,Ltd |
-
- Fructus monordicae extract
- US $0.00 / KG
- 10%-50% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Mangostin; α-Mangostin
6147-11-1
- US $0.00-0.00 / KG
- 1%-98% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Mangosteen Peel Extract / Alpha Mangostin
6147-11-1
- US $180.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd