4-HYDROXYTAMOXIFEN | 68047-06-3

4-HYDROXYTAMOXIFEN Properties

Melting point	105-107°C
Boiling point	513.45°C (rough estimate)
Density	1.1005 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	2-8°C
solubility	95% ethanol: 20 mg/mL
pka	10.35±0.15(Predicted)
form	powder
color	white
Stability	Stable. Store cool. Incompatible with strong oxidizing agents.
InChIKey	TXUZVZSFRXZGTL-OCEACIFDSA-N
CAS DataBase Reference	68047-06-3
NCI Dictionary of Cancer Terms	4-hydroxytamoxifen
FDA UNII	95K54647BZ

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08,GHS09

Signal word

Danger

Hazard statements

H302-H350-H360FD-H410

Precautionary statements

P201-P202-P264-P273-P301+P312-P308+P313

Hazard Codes

Xn

Risk Statements

20/21/22-63

Safety Statements

22-23-36

WGK Germany

3

RTECS

SL1210000

NFPA 704

	0
3		0

4-HYDROXYTAMOXIFEN price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H7904	(Z)-4-Hydroxytamoxifen ≥98% Z isomer	68047-06-3	5mg	$183	2024-03-01	Buy
Sigma-Aldrich	5.08225	InSolution Tamoxifen, 4-Hydroxy-, ( Z)- - CAS 68047-06-3 - Calbiochem	68047-06-3	2mg	$96.7	2024-03-01	Buy
Sigma-Aldrich	579002	Tamoxifen, 4-Hydroxy-, (Z)-	68047-06-3	5mg	$223	2023-01-07	Buy
Cayman Chemical	14854	(Z)-4-hydroxy Tamoxifen ≥98%	68047-06-3	1mg	$37	2024-03-01	Buy
Cayman Chemical	14854	(Z)-4-hydroxy Tamoxifen ≥98%	68047-06-3	5mg	$134	2024-03-01	Buy

Product number	Packaging	Price	Buy
H7904	5mg	$183	Buy
5.08225	2mg	$96.7	Buy
579002	5mg	$223	Buy
14854	1mg	$37	Buy
14854	5mg	$134	Buy

4-HYDROXYTAMOXIFEN Chemical Properties,Uses,Production

Chemical Properties

Powder

Uses

tamoxifen metabolite, anti-estrogen, see Tamoxifen 1,01038

Uses

A metabolite of Tamoxifen (T006000). A hydroxylated analogue of Tamoxifen with anti-estrogenic properties.

Uses

(Z)-4-Hydroxy Tamoxifen is a metabolite of Tamoxifen (T006000). (Z)-4-Hydroxy Tamoxifen is a hydroxylated analogue of Tamoxifen. (Z)-4-Hydroxy Tamoxifen is a metabolite of Tamoxifen with anti-estrogenic properties.

Uses

A hydroxylated analogue of tamoxifen with anti-estrogenic properties. A metabolite of Tamoxifen.

Definition

ChEBI: Afimoxifene is a tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen. It has a role as an antineoplastic agent, an estrogen receptor antagonist and a metabolite. It is a tertiary amino compound and a member of phenols. It is functionally related to a tamoxifen.

General Description

A cell-permeable, active metabolite of Tamoxifen (Cat. No. 579000) that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain. Also available as a 10 mM solution in EtOH (Cat. No. 508225).

Biological Activity

estrogen receptors (er) are members of the superfamily of ligand-modulated nuclear receptors that mediate the actions of steroid hormones, vitamin d, retinoids, and thyroid hormones. er is activated in vivo when bound by naturally occurring estrogens such as 17α-estradiol. in addition to regulating these physiological processes, estrogen also plays a central role in stimulating breast cancer growth. (z)-tamoxifen is a first generation selective er modulators that is currently approved by the fda and is widely used to treat estrogen-dependent breast cancers. its active metabolite, (z)-4-hydroxytamoxifen, is a potent estrogen receptor modulator.

Biochem/physiol Actions

Cell permeable: yes

in vitro

(z)-4-hydroxytamoxifen binds to er with 8-fold higher affinity than tamoxifen. it was found that only the z isomer has the required antiestrogenic activity; the (e)-4-hydroxytamoxifen has only about 5% of its affinity for the er [1].

in vivo

the antioestrogenic activities of (z)-4-hydroxytamoxifen and tamoxifen were determined after oral administration. (z)-4-hydroxytamoxifen was administered to groups of immature rats which also received s.c. injections of 0-2 μg oestradiol. both compounds produced a dose-related decrease in uterine wet weight when compared with the oestradiol-treated controls. at a dose of 1 μg/day, the antiuterotrophic effects of (z)-4-hydroxytamoxifen and tamoxifen were not significantly different but at 5μg/day, (z)-4-hydroxytamoxifen was more active (p < 0.01). (z)-4-hydroxytamoxifen therefore appears to retain its potent antioestrogenic activity after oral administration [2].

storage

-20°C

References

[1] donna d. yu and barry m. forman. simple and efficient production of (z)-4-hydroxytamoxifen, a potent estrogen receptor modulator. j. org. chem. 2003, 68, 9489-9491
[2] jordan vc, collins mm, rowsby l, prestwich g. a monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. j endocrinol. 1977 nov;75(2):305-16.

4-HYDROXYTAMOXIFEN synthesis

Synthesis of 4-HYDROXYTAMOXIFEN from 4,4'-Dihydroxybenzophenone

4-HYDROXYTAMOXIFEN Preparation Products And Raw materials

Raw materials

185223-78-3 (E)-4-Hydroxytamoxifen 4-(1-(4-(2-bromoethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol(WXC07440) 2-(4-BROMOPHENOXY)TETRAHYDRO-2H-PYRAN 1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene

Tamoxifen 4,4'-Dihydroxybenzophenone Dimethylamine Propiophenone 2-Dimethylaminoethyl chloride hydrochloride

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Preparation Products

4-HYDROXYTAMOXIFEN Suppliers

Global( 158)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32956	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	11839	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10319	58

Supplier	Advantage
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Zhengzhou Alfa Chemical Co.,Ltd	58
TargetMol Chemicals Inc.	58
Hubei Ipure Biology Co., Ltd	58

View Lastest Price from 4-HYDROXYTAMOXIFEN manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-17	4-Hydroxytamoxifen 68047-06-3	US $64.00-197.00 / mg		99.84%	10g	TargetMol Chemicals Inc.
2021-07-02	4-HYDROXYTAMOXIFEN 68047-06-3	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2019-09-02	4-HYDROXYTAMOXIFEN 68047-06-3	US $1.00 / KG	1KG	98%	1lg; 2kg; 5kg; 10kg; 100kg	Career Henan Chemical Co

4-Hydroxytamoxifen
68047-06-3
US $64.00-197.00 / mg
99.84%
TargetMol Chemicals Inc.

4-HYDROXYTAMOXIFEN
68047-06-3
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

4-HYDROXYTAMOXIFEN
68047-06-3
US $1.00 / KG
98%
Career Henan Chemical Co

4-HYDROXYTAMOXIFEN Spectrum

4-HYDROXYTAMOXIFEN(68047-06-3)¹HNMR

68047-06-3(4-HYDROXYTAMOXIFEN)Related Search:

3-hydroxytamoxife Tamoxifen alpha-[4-[2-(dimethylamino)ethoxy]phenyl]-beta-ethyl-alpha-phenylphenethyl alcohol 2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethyl-ethanamine N-Desmethyl Tamoxifen Methanethiosulfonate

(E)-4-Acetoxy Tamoxifen TAMOXIFEN-N-OXIDE desdimethyltamoxifen Endoxifen (E)-4-Alloxycarboxyl Tamoxifen

Tamoxifen EP Impurity D 4Hydroxy Tamoxifen N-Desmethyl-4-hydroxy Tamoxifen β-D-Glucuronide (E/Z Mixture) 1-(4-(2-Dimethylamino)-2-ethoxyphenyl butanone TaMoxifen DiMer

4-Benzyloxy β-Hydroxy TaMoxifen Tamoxifen Impurity 3 N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)

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trans-4-Hydroxytamoxifen, (Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol (Z)-3,4-Diphenyl-4-[4-[2-(dimethylamino)ethoxy]phenyl]-3-buten-1-ol 2-[4-[(E)-1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine 4-[(E)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol cis-4-Hydroxytamoxifen N,N-Dimethyl-2-[4-[(E)-1-(4-hydroxyphenyl)-2-phenyl-1-butenyl]phenoxy]ethanamine TAMOXIFEN 4-HYDROXY, (E) AND (Z) ISOMERS (50:50) (Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol C05011 4-OHT See H9711, H9712, or H9716 4-(1-(4-(dimethylaminoethoxy)phenyl)-2-phenyl-1-butenyl)phenol (Z)-4-OHT 4-HYDROXYTAMOXIFEN TAMOXIFEN, 4-HYDROXY- ici79,280 trans-4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)phenol (E)-4&rsquo 4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol Tamoxifen, 4-Hydroxy-, (Z)- - CAS 68047-06-3 - Calbiochem 4-Benzyloxy &beta Phenol, 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]- Tamoxifen Citrate Impurity 9（4-Hydroxy Tamoxifen） 4-HYDROXYTAMOXIFEN USP/EP/BP hydroxytamoxifen trans-4-Hydroxytamoxifen inhibit,Estrogen Receptor/ERR,4-Hydroxytamoxifen,estrogen receptor,oral,CRISPR/Cas9,4Hydroxytamoxifen,Inhibitor,(Z)-Afimoxifene,nucleus translocation,4 Hydroxytamoxifen Tamoxifen Citrate Impurity 12 (Z)-4-Hydroxytamoxifen, estrogen receptor modulator 68047-06-3 C26H29NO2 BioChemical Antibiotics Antibiotics A to Z Antibiotics G-M Aromatics Metabolites & Impurities Drug Analogues Intermediates & Fine Chemicals Pharmaceuticals Steroids