HERBIMYCIN A
- CAS No.
- 70563-58-5
- Chemical Name:
- HERBIMYCIN A
- Synonyms
- C11225;herbimycin;HERBIMYCIN A;(15r)-geldanamyci;antibiotictan420f;HerbiMycin, TAN 420F;HERBIMYCIN A USP/EP/BP;Herbimycin A, Streptomyces sp.;HERBIMYCIN A, STREPTOMYCES SPECIES;HERBIMYCIN A, STREPTOMYCES HYGROSCOPICUS
- CBNumber:
- CB0756080
- Molecular Formula:
- C30H42N2O9
- Molecular Weight:
- 574.66
- MDL Number:
- MFCD00151702
- MOL File:
- 70563-58-5.mol
- MSDS File:
- SDS
| Melting point | 229-231 °C |
|---|---|
| Boiling point | 752℃ |
| Density | 1.19±0.1 g/cm3(Predicted) |
| Flash point | >110°(230°F) |
| storage temp. | −20°C |
| solubility | DMSO: 7.5 mg/mL DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1. |
| pka | 8.56±0.70(Predicted) |
| form | powder |
| color | yellow |
| Sensitive | Light Sensitive & Hygroscopic |
| BRN | 4834067 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| FDA UNII | 815WDV2HST |
SAFETY
Risk and Safety Statements
| Hazard Codes | Xi |
|---|---|
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25-36-26 |
| WGK Germany | 3 |
| RTECS | LX8930000 |
| F | 10-21 |
| HS Code | 29419000 |
HERBIMYCIN A price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H6649 | Herbimycin A from Streptomyces hygroscopicus ≥95% (HPLC), powder | 70563-58-5 | 0.1mg | $317 | 2024-03-01 | Buy |
| Alfa Aesar | J66427 | Herbimycin A, 95% | 70563-58-5 | 1mg | $962 | 2024-03-01 | Buy |
| Cayman Chemical | 15504 | Herbimycin A ≥99% | 70563-58-5 | 500μg | $380 | 2024-03-01 | Buy |
| Cayman Chemical | 15504 | Herbimycin A ≥99% | 70563-58-5 | 2.5mg | $1231 | 2024-03-01 | Buy |
| Sigma-Aldrich | H6649 | Herbimycin A from Streptomyces hygroscopicus ≥95% (HPLC), powder | 70563-58-5 | 1mg | $428 | 2024-03-01 | Buy |
HERBIMYCIN A Chemical Properties,Uses,Production
Description
Herbimycin A (70563-58-5) is an ansamycin antibiotic. Inhibits HSP90 and associated client proteins including v-Src, Bcr-Abl, Raf-1 and ErbB2.1,2 Herbimycin A reverts tyrosine kinase-induced oncogenic transformation without direct inhibition of phosphorylation activity.1 Inhibits angiogenesis in a rat retinopathy model.3
Uses
Herbimycin A is an inhibitor of c-Abl, HSP 90, c-Src, c-Yes, Fes, and Ros. It is a COVID19-related research product.
Uses
Herbimycin A is a benzoquinone ansamycin antibiotic from Streptomyces. It has herbicidal activity and acts as a cell-permeable inhibitor of non-receptor tyrosine kinases and the heat shock protein Hsp90. Herbimycin A inhibits Bcr-Abl with an IC50 value of 5 μM, a concentration that also effectively blocks Src, Yes, Fps, Ros, and ErbB but not protein kinases (PK) PKA, PKC, Rac, Myc, or Raf. Presumably through its effects on tyrosine kinase signaling, herbimycin A also impairs endothelial cell proliferation in the context of angiogenesis, NF-κB activation, phosphorylation of phospholipase C-γ1, and eggshell formation in schistosome parasites. Ansamycins, including herbimycin A and geldanamycin , bind Hsp90 and destabilize client proteins, including Src, Bcr-Abl, and ErbB2, leading to their ubiquitination and proteasomal degradation.
Uses
Herbimycin A is the major analogue of a complex of benzoquinone ansamycin antibiotics isolated from a Streptomyces hygroscopicus. Herbimycin A inhibits the 90-kDa heat-shock protein (Hsp90) which provides essential chaperone support to various signal transduction molecules, including certain steroid hormone receptors and select kinases. Herbimycin also inhibits protein tyrosine kinase and angiogenesis.
Definition
ChEBI: A 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It is an ansamycin antibiotic that induces apoptosis and displays antitumour effects.
General Description
A cell-permeable, potent inhibitor of protein tyrosine kinases. Inhibits p60v-src (IC50 = 12 μM) autophosphorylation. Irreversibly binds to the sulfhydryl groups of the kinase. Dose-dependently inhibits PDGF-induced phospholipase D activation (IC50 = 8 μg/ml). Also, reported to inhibit c-src related bone resorption (IC50 = 70 nM). Inhibits angiogenesis in chick chorioallantoic membrane and blocks anti-CD3 monoclonal antibody-induced apoptosis of thymocytes. Several mammalian cell lines transformed with tyrosine kinase oncogenes (src, abl, fps, ros, yes, erbB) show reversion from the transformed to the normal phenotype after treatment with herbimycin A.
Biological Activity
Ansamycin antibiotic that acts as a Src family kinase inhibitor. Binds to the SH domain and inhibits the activity of p60 v-src and p210 BCR-ABL . Exhibits antiangiogenic activity in endothelial cells in vitro . Also inhibits Hsp90 and impairs recovery from heat shock.
Biochem/physiol Actions
Cell permeable: yes
storage
-20°C
References
1) Whitesell et al. (1994), Inhibition of heat shock protein HSP-90-pp60vsrc heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation; Proc. Natl. Acad. Sci. USA, 91 8324 2) Blagosklonny et al. (2002), Hsp-90-associated oncoproteins: multiple targets of geldanamycin and it’s analogs; Leukemia, 16 455 3) GW McCollum et al. (2004), Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity; Exp. Eye Res., 78 987
HERBIMYCIN A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29811 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7724 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19741 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Shaanxi Xianhe Biotech Co., Ltd | +8617709210191 | Jerry@xhobio.com | China | 737 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-400-6206333 18521732826 | market@aladdin-e.com | China | 25003 | 65 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
View Lastest Price from HERBIMYCIN A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-26 | HERBIMYCIN A
70563-58-5
|
US $1.00 / g | 1g | ≥98% | g/kg/Ton | Career Henan Chemical Co |
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- HERBIMYCIN A
70563-58-5
- US $1.00 / g
- ≥98%
- Career Henan Chemical Co