Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-

1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-

1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- Structure
1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- structure
CAS No.
1227098-15-8
Chemical Name:
1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-
Synonyms
T63;NF-κB-IN-1;AC17 NF-κB-IN-1;NF-kB-IN-1(AC17);(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4-(4-hydroxy-3-methoxybenzylidene)hepta-1,6-diene-3,5-dione;1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-;pathway,4-arylidene,Inhibitor,inhibit,IKK,crucumin,cancer,A549,NFκBIN1,I kappa B kinase,signaling,NF κB IN 1,IκB kinase,NF-κB
CBNumber:
CB08367286
Molecular Formula:
C31H30O8
Molecular Weight:
530.57
MDL Number:
MOL File:
1227098-15-8.mol
Last updated:2024-11-18 17:01:59
Request For Quotation

1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- Properties

Boiling point 732.0±60.0 °C(Predicted)
Density 1.233±0.06 g/cm3(Predicted)
pka 9.27±0.31(Predicted)
form Solid
color Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0148832 NF-κB-IN-1 1227098-15-8 5mg $480 2021-12-16 Buy
ChemScene CS-0148832 NF-κB-IN-1 1227098-15-8 10mg $800 2021-12-16 Buy
ChemScene CS-0148832 NF-κB-IN-1 1227098-15-8 25mg $1550 2021-12-16 Buy
ChemScene CS-0148832 NF-κB-IN-1 1227098-15-8 50mg $2400 2021-12-16 Buy
ChemScene CS-0148832 NF-κB-IN-1 1227098-15-8 100mg $3600 2021-12-16 Buy
Product number Packaging Price Buy
CS-0148832 5mg $480 Buy
CS-0148832 10mg $800 Buy
CS-0148832 25mg $1550 Buy
CS-0148832 50mg $2400 Buy
CS-0148832 100mg $3600 Buy

1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- Chemical Properties,Uses,Production

Biological Activity

NF-κB-IN-1, a 4-arylene curcumin analog, is a potent NF-κB signaling pathway inhibitor. It directly inhibits IKK to block NF-κB activation. It can effectively inhibit the viability of lung cancer cells and attenuate the clonal activity of A549 cells.

in vitro

NF-κB-IN-1 (compound 17) (0.001-100 μM; 72 h) inhibits the growth of A549, H1944, H460 and H157 cells, with GI 50 s of 0.72, 0.07, 0.13, and 0.16 μM, respectively.

target

IKK

1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- Preparation Products And Raw materials

Raw materials

Preparation Products

1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- Suppliers

Global( 19)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38632 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52925 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 4600 55
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8011 62
Henan Weituxi Chemical Technology Co., Ltd. 0371-63284658 18135795563 2885349392@qq.com China 10054 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9409 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 15801484223; psaitong@jm-bio.com China 29774 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62075 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Tianjin Kailiqi Biotechnology Co., Ltd. 55
ShangHai Biochempartner Co.,Ltd 62
Henan Weituxi Chemical Technology Co., Ltd. 58
DC Chemicals 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
Bide Pharmatech Ltd. 58

View Lastest Price from 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
NF-κB-IN-1 pictures 2024-11-18 NF-κB-IN-1
1227098-15-8
 US $169.00-579.00 / mg 99.03% 10g TargetMol Chemicals Inc.
  • NF-κB-IN-1 pictures
  • NF-κB-IN-1
    1227098-15-8
  • US $169.00-579.00 / mg
  • 99.03%
  • TargetMol Chemicals Inc.

1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- Spectrum

1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-(1227098-15-8)1HNMR
1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- AC17 NF-κB-IN-1 NF-κB-IN-1 NF-kB-IN-1(AC17) (1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4-(4-hydroxy-3-methoxybenzylidene)hepta-1,6-diene-3,5-dione pathway,4-arylidene,Inhibitor,inhibit,IKK,crucumin,cancer,A549,NFκBIN1,I kappa B kinase,signaling,NF κB IN 1,IκB kinase,NF-κB T63 1227098-15-8