ChemicalBook >> CAS DataBase List >>1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-
1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-
- CAS No.
- 1227098-15-8
- Chemical Name:
- 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-
- Synonyms
- NF-κB-IN-1;AC17 NF-κB-IN-1;NF-kB-IN-1(AC17);(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4-(4-hydroxy-3-methoxybenzylidene)hepta-1,6-diene-3,5-dione;1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-;pathway,4-arylidene,Inhibitor,inhibit,IKK,crucumin,cancer,A549,NFκBIN1,I kappa B kinase,signaling,NF κB IN 1,IκB kinase,NF-κB
- CBNumber:
- CB08367286
- Molecular Formula:
- C31H30O8
- Molecular Weight:
- 530.57
- MDL Number:
- MOL File:
- 1227098-15-8.mol
Last updated:2024-07-02 08:54:58
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0148832 | NF-κB-IN-1 | 1227098-15-8 | 5mg | $480 | 2021-12-16 | Buy |
ChemScene | CS-0148832 | NF-κB-IN-1 | 1227098-15-8 | 10mg | $800 | 2021-12-16 | Buy |
ChemScene | CS-0148832 | NF-κB-IN-1 | 1227098-15-8 | 25mg | $1550 | 2021-12-16 | Buy |
ChemScene | CS-0148832 | NF-κB-IN-1 | 1227098-15-8 | 50mg | $2400 | 2021-12-16 | Buy |
ChemScene | CS-0148832 | NF-κB-IN-1 | 1227098-15-8 | 100mg | $3600 | 2021-12-16 | Buy |
1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- Chemical Properties,Uses,Production
Biological Activity
NF-κB-IN-1, a 4-arylene curcumin analog, is a potent NF-κB signaling pathway inhibitor. It directly inhibits IKK to block NF-κB activation. It can effectively inhibit the viability of lung cancer cells and attenuate the clonal activity of A549 cells.
in vitro
NF-κB-IN-1 (compound 17) (0.001-100 μM; 72 h) inhibits the growth of A549, H1944, H460 and H157 cells, with GI 50 s of 0.72, 0.07, 0.13, and 0.16 μM, respectively.
target
IKK
1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- Preparation Products And Raw materials
Raw materials
Preparation Products
1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- Suppliers
Global( 15)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3732 | 55 |
ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8013 | 62 |
Henan Weituxi Chemical Technology Co., Ltd. | 0371-63284658 18135795563 | 2885349392@qq.com | China | 10003 | 58 |
DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29778 | 58 |
Bide Pharmatech Ltd. | 400-1647117 15221909166 | product02@bidepharm.com | China | 63720 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24016 | 58 |
1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- Spectrum
1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-
AC17 NF-κB-IN-1
NF-κB-IN-1
NF-kB-IN-1(AC17)
(1E,6E)-1,7-Bis(3,4-dimethoxyphenyl)-4-(4-hydroxy-3-methoxybenzylidene)hepta-1,6-diene-3,5-dione
pathway,4-arylidene,Inhibitor,inhibit,IKK,crucumin,cancer,A549,NFκBIN1,I kappa B kinase,signaling,NF κB IN 1,IκB kinase,NF-κB
1227098-15-8