Propanamide, 2-(4-chlorophenoxy)-N-[4-[(4-cyanophenyl)methoxy]phenyl]-2-methyl-
![Propanamide, 2-(4-chlorophenoxy)-N-[4-[(4-cyanophenyl)methoxy]phenyl]-2-methyl- Structure](CAS/20210111/GIF/2493239-46-4.gif)
- CAS No.
- 2493239-46-4
- Chemical Name:
- Propanamide, 2-(4-chlorophenoxy)-N-[4-[(4-cyanophenyl)methoxy]phenyl]-2-methyl-
- Synonyms
- AMPK activator 4;2-(4-chlorophenoxy)-N-(4-((4-cyanobenzyl)oxy)phenyl)-2-methylpropanamide;Propanamide, 2-(4-chlorophenoxy)-N-[4-[(4-cyanophenyl)methoxy]phenyl]-2-methyl-
- CBNumber:
- CB08376338
- Molecular Formula:
- C24H21ClN2O3
- Molecular Weight:
- 420.89
- MDL Number:
- MOL File:
- 2493239-46-4.mol
| Boiling point | 648.7±55.0 °C(Predicted) |
|---|---|
| Density | 1.28±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 250 mg/mL (593.98 mM; Need ultrasonic) |
| pka | 13.79±0.70(Predicted) |
| form | Solid |
| color | White to off-white |
Propanamide, 2-(4-chlorophenoxy)-N-[4-[(4-cyanophenyl)methoxy]phenyl]-2-methyl- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0133422 | AMPKactivator4 99.42% | 2493239-46-4 | 5mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-0133422 | AMPKactivator4 99.42% | 2493239-46-4 | 10mg | $450 | 2021-12-16 | Buy |
| ChemScene | CS-0133422 | AMPKactivator4 99.42% | 2493239-46-4 | 25mg | $850 | 2021-12-16 | Buy |
| ChemScene | CS-0133422 | AMPKactivator4 99.42% | 2493239-46-4 | 50mg | $1350 | 2021-12-16 | Buy |
| ChemScene | CS-0133422 | AMPKactivator4 99.42% | 2493239-46-4 | 100mg | $1950 | 2021-12-16 | Buy |
Propanamide, 2-(4-chlorophenoxy)-N-[4-[(4-cyanophenyl)methoxy]phenyl]-2-methyl- Chemical Properties,Uses,Production
Biological Activity
AMPK activator 4 is a potent AMPK activator without inhibition of mitochondrial complex I. AMPK activator 4 selectively activates AMPK in the muscle tissues. AMPK activator 4 dose-dependently improves glucose tolerance in normal mice, and significantly lowers fasting blood glucose level and ameliorates insulin resistance in db/db diabetic mice. Anti-hyperglycemic effect[1]. AMPK activator 4 (compound B10) (0-20 μM; 12-24 hours) induces phosphorylation of AMPK and its downstream protein ACC[1].AMPK activator 4-mediated AMPK phosphorylation requires LKB1[1].AMPK activator 4 slight decreases the viability of HepG2 cells after 72 hours of treatment at 10-20 μM[1]. AMPK activator 4 (100 mg/kg; Intragastrical administration; daily for 9 weeks) shows anti-hyperglycemic effect[1].
References
[1]. Sun G, You Y, Li H, et al. Discovery of AdipoRon analogues as novel AMPK activators without inhibiting mitochondrial complex I. Eur J Med Chem. 2020;200:112466.
Propanamide, 2-(4-chlorophenoxy)-N-[4-[(4-cyanophenyl)methoxy]phenyl]-2-methyl- Preparation Products And Raw materials
Raw materials
Preparation Products
Propanamide, 2-(4-chlorophenoxy)-N-[4-[(4-cyanophenyl)methoxy]phenyl]-2-methyl- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 4182 | 55 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23980 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 5012 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | ET-market@chemextension.com | China | 19429 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9268 | 58 |