Alitame | 80863-62-3

Alitame Properties

Melting point	136-147°
alpha	D25 +40 to +50° (c = 1 in water)
Boiling point	608.5±55.0 °C(Predicted)
Density	1.25±0.1 g/cm3(Predicted)
solubility	Methanol (Slightly)
form	Solid
pka	3.71±0.10(Predicted)
color	White to Off-White
Odor	odorless
Odor Type	odorless
LogP	1.508 (est)
CAS DataBase Reference	80863-62-3
FDA UNII	PCE8DAE750

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P301+P312+P330
HS Code	29400090

Alitame price More Price(13)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	001778	Alitame	80863-62-3	1g	$425	2021-12-16	Buy
Biosynth Carbosynth	FA17282	Alitame	80863-62-3	5G	$575	2021-12-16	Buy
American Custom Chemicals Corporation	API0004994	ALITAME 95.00%	80863-62-3	10G	$2194.5	2021-12-16	Buy
Biosynth Carbosynth	FA17282	Alitame	80863-62-3	250mg	$100	2021-12-16	Buy
Biosynth Carbosynth	FA17282	Alitame	80863-62-3	500mg	$150	2021-12-16	Buy

Product number	Packaging	Price	Buy
001778	1g	$425	Buy
FA17282	5G	$575	Buy
API0004994	10G	$2194.5	Buy
FA17282	250mg	$100	Buy
FA17282	500mg	$150	Buy

Alitame Chemical Properties,Uses,Production

Chemical Properties

White Solid

Chemical Properties

Alitame is a white nonhygroscopic crystalline powder; odorless or having a slight characteristic odor.

Physical properties

Alitame [L-a-aspartyl-N-(2,2,4,4-tetramethyl-3-thietanyl)-D-alaninamide] is a sweetener based on an amino acid. It is a very intense sweetener, possessing a sweetening power of about 2000 times that of sucrose. It also exhibits a clean sweet taste similar to sucrose. Although it is metabolized, so little is needed that its caloric contribution is insignificant. Alitame is prepared from the amino acids, L-aspartic acid, D-alamine, and a novel amine.

Characteristics

Alitame is an amino acidbased sweetener developed by Pfizer Central Research from l-aspartic acid, d-alanine, and 2,2,4,4-tetraethylthioethanyl amine. A terminal amide group instead of the methyl ester constituent of ASP was used to improve the hydrolytic stability. The incorporation of d-alanine as a second amino acid in place of l-phenylalanine has resulted in optimum sweetness. The increased steric and lipophilic bulk on a small ring with a sulfur derivative has provided a very sweet product and good taste qualities.
Alitame offers several benefits such as stability at high temperatures and a broader pH range. For instance, it is stable for over a year at pH 6–8 and room temperature and withstands pasteurization. However, prolonged storage of acidic solutions at high temperatures or in combination with certain ingredients (hydrogen peroxide or sodium bisulfite) may produce off-flavors. In the presence of high levels of reducing sugars, alitame can undergo Maillard reactions.

History

Alitame, L-α-aspartyl-D-alanine N-(2,2,4,4-tetra methylthietan-3-yl)amide (5), was developed by Pfizer, but is owned by Danisco now. In 1986, Pfizer filed a food additive petition with the FDA. As of 2006, it was still pending. Alitame was approved for use as a sweetener by Australia in 1993, by China, Mexico, and New Zealand in 1994, by Indonesia in 1995, and by Colombia in 1996.

Uses

Non-nutritive sweetener.

Uses

Alitame is a dipeptide amide derivative of aspartic acid used as an artificial sweetener. Alitame is about ten times sweeter than Aspartame (A790015) with a half life about twice as long.

Uses

Alitame [L-a-aspartyl-N-(2,2,4,4-tetramethyl-3-thietanyl)-D-alaninamide] is a sweetener based on an amino acid. It is a very intense sweetener, possessing a sweetening power of about 2000 times that of sucrose. It also exhibits a clean sweet taste similar to sucrose. Although it is metabolized, so little is needed that its caloric contribution is insignificant. Alitame is prepared from the amino acids, L-aspartic acid, D-alamine, and a novel amine.

Production Methods

Alitame may be synthesized by a number of routes.For example, 3-(D-alaninamido)-2,2,4,4-tetramethylthietane is dissolved in water and L-aspartic acid N-thiocarboxyanhydride is then added in portions with vigorous stirring, maintaining the pH of 8.5–9.5. The pH is then adjusted to 5.5 and p-toluenesulfonic acid monohydrate is added over a period of one hour. The precipitated crystalline p-toluenesulfonate salt is collected by filtration. To obtain alitame from its salt, a mixture of Amberlite LA-1 (liquid anion exchange resin), dichloromethane, deionized water, and the salt is stirred for one hour, resulting in two clear layers. The aqueous layer is treated with carbon, clarified by filtration, and cooled to crystallize alitame.
Alternatively, tetramethylthietane amine is condensed with anNprotected form of D-alanine to give alanyl amide. This is then coupled to a protected analogue of L-aspartic acid to give a crude form of alitame. The crude product is then purified.

Definition

ChEBI: Alitame is a dipeptide.

Pharmaceutical Applications

Alitame is an intense sweetening agent developed in the early 1980s and is approximately 2000 times sweeter than sucrose. It has an insignificant energy contribution of 6 kJ (1.4 kcal) per gram of alitame.
Alitame is currently primarily used in a wide range of foods and beverages at a maximum level of 40–300 mg/kg.

Safety Profile

The Joint Expert Committee on Food Additives (JECFA) concluded that alitame was not carcinogenic and did not show reproductive toxicity. In 1996, an ADI of 0–1 mg/kg of body weight was allocated. It is approved for use in Australia, New Zealand, Mexico, and China. A food additive petition was submitted to the FDA in 1986, and approval is awaited. In the petition, the estimated daily intake is 0.34 mg/kg of body weight, which represents the amount if alitame is the only sweetener in the diet. The level at which no observed adverse effects occur in animals is 100 mg/ kg. Potential uses include baked goods, baking mixes, hot and cold beverages, dry beverage mixes, tabletop sweeteners, chewing gum, candies, frozen desserts, and pharmaceuticals. Alitame has been approved for use in some countries such as Australia, Mexico, New Zealand, and China, but not in the United States or the EU.

Safety

Alitame is a relatively new intense sweetening agent used primarily in foods and confectionary. It is generally regarded as a relatively nontoxic and nonirritant material.
Chronic animal studies in mice, rats, and dogs carried out for a minimum of 18 months at concentrations >100 mg/kg per day exhibited no toxic or carcinogenic effects. In people, no evidence of untoward effects were observed following ingestion of 15 mg/kg per day for two weeks.
Following oral administration 7–22% of alitame is unabsorbed and excreted in the feces. The remaining amount is hydrolyzed to aspartic acid and alanine amide. The aspartic acid is metabolized normally and the alanine amide excreted in the urine as a sulfoxide isomer, as the sulfone, or conjugated with glucuronic acid.
The WHO has set an acceptable daily intake of alitame at up to 0.1 mg/kg body-weight.
LD₅₀ (mouse, oral): >5 g/kg
LD₅₀ (rabbit, skin): >2 g/kg
LD₅₀ (rat, oral): >5 g/kg

Metabolism

Alitame is noncariogenic. From an oral intake, 7%–22% is unabsorbed and excreted in the feces. The remainder is hydrolyzed to aspartic acid and alanine amide. The aspartic acid is normally metabolized, and the alanine amide is excreted in the urine as a sulfoxide isomer, sulfone, or conjugated with glucuronic acid. The incomplete absorption and metabolism result in a core value of 1.4 kcal g?1.

storage

Alitame is stable in dry, room temperature conditions but undergoes degradation at elevated temperatures or when in solution at low pH. Alitame can degrade in a one-stage process to aspartic acid and alanine amide (under harsh conditions) or in a slow two-stage process by first degrading to its β-aspartic isomer and then to aspartic acid and alanine amide. At pH 5–8, alitame solutions at 238℃ have a half-life of approximately 4 years. At pH 2 and 238℃ the half-life is 1 year.
Alitame should be stored in a well-closed container in a cool, dry place.

Incompatibilities

Alitame may be incompatible with oxidizing and reducing substances or strong acids and bases.

Regulatory Status

Alitame is approved for use in food applications in a number of countries worldwide including Australia, Chile, China, Mexico, and New Zealand.

Alitame Preparation Products And Raw materials

Raw materials

D-Alanine L-ASPARTIC ACID

Preparation Products

Alitame Suppliers

Global( 166)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Fengjia New Material Co., Ltd	+86-0311-87836622 +86-17333973358	sales06@hbduling.cn	China	8054	58
Hebei Kingfiner Technology Development Co.Ltd	+86-15532196582 +86-15373005021	lisa@kingfinertech.com	China	2990	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3002	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21639	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9220	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	sales@fine-chemtech.com	CHINA	885	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29886	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58

Supplier	Advantage
Hebei Fengjia New Material Co., Ltd	58
Hebei Kingfiner Technology Development Co.Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Nanjing Finetech Chemical Co., Ltd.	55
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58

View Lastest Price from Alitame manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-01	Alitame 80863-62-3	US $99.00-35.00 / kg	1kg	99%	20ton	Hebei Zhuanglai Chemical Trading Co.,Ltd
2024-10-28	Alitame anhydrous 80863-62-3	US $1980.00-2500.00 / mg			10g	TargetMol Chemicals Inc.
2024-05-24	Alitame 80863-62-3	US $0.00-0.00 / kg	1kg	0.99	50000kg	Hebei Kingfiner Technology Development Co.Ltd

Alitame
80863-62-3
US $99.00-35.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co.,Ltd

Alitame anhydrous
80863-62-3
US $1980.00-2500.00 / mg
TargetMol Chemicals Inc.

Alitame
80863-62-3
US $0.00-0.00 / kg
0.99
Hebei Kingfiner Technology Development Co.Ltd

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Sucralose 3-Amino-2,2,4,4-tetramethylthietane D-Alaninamide

1of4

(S)-3-amino-4-(((R)-1-amino-1-oxopropan-2-yl)(2,2,4,4-tetramethylthietan-3-yl)amino)-4-oxobutanoic acid (S)-3-Amino-4-oxo-4-(((R)-1-oxo-1-((2,2,4,4-tetramethylthietan-3-yl)amino)propan-2-yl)amino)bu (S)-3-((R)-1-(2,2,4,4-TETRAMETHYLTHIETAN-3-YLCARBAMOYL)ETHYLCARBAMOYL)-3-AMINOPROPANOIC ACID Alitame l-alpha-aspartyl-n-(2,2,4,4-tetramethyl-3-thietanyl)-d-alaninamide l-α-aspartyl-N-(2，2，4，4-tetramethyl-3-thietanyl)-D-alaninamide CP 54802 (S)-3-AMino-4-oxo-4-(((R)-1-oxo-1-((2,2,4,4-tetraMethylthietan-3-yl)aMino)propan-2-yl)aMino)butanoic acid Alitame Solution in Water, 100μg/mL Aclame anhydrous Alitame USP/EP/BP Sweetener Alitame (3s)-3-amino-4-oxo-4-[[(2r)-1-oxo-1-[(2,2,4,4-tetramethylthietan-3-yl)amino]propan-2-yl]amino]butanoic acid (S)-3-Amino-4-oxo-4-(((R)-1-oxo-1-((2,2,4,4-tetramethylthietan-3-yl)amino)propan-2-yl)amino)butan D-Alaninamide, L-α-aspartyl-N-(2,2,4,4-tetramethyl-3-thietanyl)- D-Alaninamide, L-a-aspartyl-N-(2,2,4,4-tetramethyl-3-thietanyl)- Alitian Methylparaben Impurity 25 alitame sweetener altanle Alitame in Water 80863-62-3 C14H25N3O4S25H2O C14H25N3O4S Amino Acids & Derivatives Heterocycles Intermediates & Fine Chemicals Pharmaceuticals