ChemicalBook >> CAS DataBase List >>Bilaid C
Bilaid C
- CAS No.
- 2393866-13-0
- Chemical Name:
- Bilaid C
- Synonyms
- Bilaid C;L-tyrosyl-D-valyl-L-valyl-D-phenylalanine;D-Phenylalanine, L-tyrosyl-D-valyl-L-valyl-
- CBNumber:
- CB08571023
- Molecular Formula:
- C28H38N4O6
- Molecular Weight:
- 526.62
- MDL Number:
- MOL File:
- 2393866-13-0.mol
Last updated:2023-05-21 10:59:17
Bilaid C Chemical Properties,Uses,Production
Biological Activity
Bilaid C is a tetrapeptide μ-opioid receptor agonist (Ki = 210 nM in HEK293 cell membranes expressing the human receptor) that has been found in Penicillium.1 It inhibits forskolin-induced cAMP accumulation by 77% in HEK293 cells expressing the human μ-opioid receptor when used at a concentration of 10 μM. Bilaid C induces inward rectifying potassium channel (Kir) currents in rat locus coeruleus slices that endogenously express high levels of the μ-opioid receptor (EC50 = 4.2 μM).
References
1.Dekan, Z., Sianati, S., Yousuf, A., et al.A tetrapeptide class of biased analgesics from an Australian fungus targets the μ-opioid receptorProc. Natl. Acad. Sci. USA116(44)22353-22358(2019)
Bilaid C Preparation Products And Raw materials
Raw materials
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Bilaid C Suppliers
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Bilaid C
D-Phenylalanine, L-tyrosyl-D-valyl-L-valyl-
L-tyrosyl-D-valyl-L-valyl-D-phenylalanine
2393866-13-0