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Bilaid C

CAS No.
2393866-13-0
Chemical Name:
Bilaid C
Synonyms
Bilaid C;L-tyrosyl-D-valyl-L-valyl-D-phenylalanine;D-Phenylalanine, L-tyrosyl-D-valyl-L-valyl-
CBNumber:
CB08571023
Molecular Formula:
C28H38N4O6
Molecular Weight:
526.62
MDL Number:
MOL File:
2393866-13-0.mol
Last updated:2023-05-21 10:59:17

Bilaid C Properties

Boiling point 866.4±65.0 °C(Predicted)
Density 1.222±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
pka 3.50±0.10(Predicted)
form A solid

Bilaid C Chemical Properties,Uses,Production

Biological Activity

Bilaid C is a tetrapeptide μ-opioid receptor agonist (Ki = 210 nM in HEK293 cell membranes expressing the human receptor) that has been found in Penicillium.1 It inhibits forskolin-induced cAMP accumulation by 77% in HEK293 cells expressing the human μ-opioid receptor when used at a concentration of 10 μM. Bilaid C induces inward rectifying potassium channel (Kir) currents in rat locus coeruleus slices that endogenously express high levels of the μ-opioid receptor (EC50 = 4.2 μM).

References

1.Dekan, Z., Sianati, S., Yousuf, A., et al.A tetrapeptide class of biased analgesics from an Australian fungus targets the μ-opioid receptorProc. Natl. Acad. Sci. USA116(44)22353-22358(2019)

Bilaid C Preparation Products And Raw materials

Raw materials

Preparation Products

Bilaid C Suppliers

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Bilaid C D-Phenylalanine, L-tyrosyl-D-valyl-L-valyl- L-tyrosyl-D-valyl-L-valyl-D-phenylalanine 2393866-13-0