3,6-diamino-10-methylacridinium chloride monohydrochloride
- CAS No.
- 6034-59-9
- Chemical Name:
- 3,6-diamino-10-methylacridinium chloride monohydrochloride
- Synonyms
- Nsc163949;3,6-diamino-10-methylacridinium chloride monohydrochloride;Acridinium, 3,6-diamino-10-methyl-, chloride, monohydrochloride
- CBNumber:
- CB0916107
- Molecular Formula:
- C14H15Cl2N3
- Molecular Weight:
- 296.195
- MDL Number:
- MOL File:
- 6034-59-9.mol
| FDA UNII | 0596YAL51J |
|---|
3,6-diamino-10-methylacridinium chloride monohydrochloride Chemical Properties,Uses,Production
Originator
Acriflavine hydrochloride,ABCR GmbH and Co. KG
Manufacturing Process
4,4-Diaminodiphenylmethane reacted with HNO3 and as a result of this reaction 4,4-diamino-2,2-dinitro-diphenylmethane was obtained. By reducing of 4,4-diamino-2,2-dinitro-diphenylmethane with HCl and Sn, 2,2,4,4-tetraaminodiphenylmethane was produced, which at heating to 150°C gave 3,6-diamino-9,10-dihydroacridine. The 3,6-diamino-9,10-dihydroacridine by oxidation with FeCl3 was converted to 3,6-diaminoacridine. 3,6-Diaminoacridine was reacted with acetanhydride and 3,6-bis- (acetylamino)-acridine was produced. 3,6-Bis-(acetylamino)-acridine was methylated by p-toluolsulfomethyl ether and 3,6-bis-(acetylamino)-10-methylacridinumtosylate was produced. Then the 3,6-bis-(acetylamino)-10-methylacridinumtosylate was converted to 3,6-diamino-10-methylacridinum chloride (acriflavinum chloride) by reaction with hydrochloric acid.
Therapeutic Function
Antiseptic, Topical antibacterial