ChemicalBook >> CAS DataBase List >>1H-Pyrazole-3-sulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-1-(1-methylethyl)-, sodium salt (1:1)

1H-Pyrazole-3-sulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-1-(1-methylethyl)-, sodium salt (1:1)

1H-Pyrazole-3-sulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-1-(1-methylethyl)-, sodium salt (1:1) structure

CAS No.: 2380032-29-9

Chemical Name:: 1H-Pyrazole-3-sulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-1-(1-methylethyl)-, sodium salt (1:1)

Synonyms: Emlenoflast sodium;1H-Pyrazole-3-sulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-1-(1-methylethyl)-, sodium salt (1:1)

CBNumber:: CB09315888

Molecular Formula:: C19H25N4NaO3S

Molecular Weight:: 412.48

MDL Number:

MOL File:: 2380032-29-9.mol

Last updated:2024-07-02 08:54:58

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1H-Pyrazole-3-sulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-1-(1-methylethyl)-, sodium salt (1:1) Properties

storage temp.	-20°C, away from moisture
solubility	DMSO : 240 mg/mL (584.70 mM; Need ultrasonic)
form	Solid
color	White to off-white

1H-Pyrazole-3-sulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-1-(1-methylethyl)-, sodium salt (1:1) Chemical Properties,Uses,Production

Biological Activity

MCC7840 sodium, a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. MCC7840 sodium can be used for the research of inflammatory diseases[1][2]. MCC7840, a MCC950 analogue, shows useful activity in the inhibition of activation of the NLRP3 inflammasome, with an IC50 of <100 nM[1]. MCC7840 (4 mg/kg; i.v.) exhibits the half-life (3.39 h), AUC0-last (107097 ng?h/mL) and CL (0.621 mL/min/kg) in mice[2].MCC7840 (20 mg/kg; p.o.) exhibits the oral bioavailability (67.2%), Cmax (60467 ng/mL) and half-life (5.02 h) in mice[2].

References

[1]. El-Sharkawy LY, et, al. Inhibiting the NLRP3 Inflammasome. Molecules. 2020 Nov 25;25(23):5533. [2]. O’neill L, et, al. Sulfonylureas and related compounds and use of same. WO2016131098A1.

1H-Pyrazole-3-sulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-1-(1-methylethyl)-, sodium salt (1:1) Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Pyrazole-3-sulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-1-(1-methylethyl)-, sodium salt (1:1) Suppliers

Global( 11)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32836	60
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8014	62
Shanghai Rechem science Co., Ltd.	21-31433387 15618786686	sales@rechemscience.com	China	2991	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9412	58
Chunchuang (Wuhan) Technology Co., Ltd	15342225168	yutianchun2007@126.com	China	9998	58
Wuhan Shanhai Zhihe Biotechnology Co., Ltd.	17771424646	shoubull@126.com	China	962	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	23980	58
https://hanhongsci.com/	021-54306202 18917919676	info@hanhongsci.com	China	29978	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9268	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Aladdin Scientific	58
ShangHai Biochempartner Co.,Ltd	62
Shanghai Rechem science Co., Ltd.	58
DC Chemicals	58
Chunchuang (Wuhan) Technology Co., Ltd	58
Wuhan Shanhai Zhihe Biotechnology Co., Ltd.	58
TargetMol Chemicals Inc.	58
https://hanhongsci.com/	58
RD International Technology Co., Limited	58

1H-Pyrazole-3-sulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-1-(1-methylethyl)-, sodium salt (1:1) Emlenoflast sodium 2380032-29-9 C19H25N4NaO3S