1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT
- CAS No.
- 168021-79-2
- Chemical Name:
- 1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT
- Synonyms
- CPI22;D03875;HPN-07;CS-791;CPI 22;CPI-22;CXY059;OKN007;CXY 059;CXY-059
- CBNumber:
- CB11009515
- Molecular Formula:
- C11H14NNa2O7S2
- Molecular Weight:
- 382.3409
- MDL Number:
- MFCD09833648
- MOL File:
- 168021-79-2.mol
- MSDS File:
- SDS
Melting point | >300 °C |
---|---|
storage temp. | -20°C |
solubility | Soluble in DMSO |
form | powder |
color | white to beige |
FDA UNII | 7M1J3HN9VO |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
NFPA 704 |
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1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT price More Price(20)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML2163 | HPN-07 ≥98% (HPLC) | 168021-79-2 | 5mg | $64.9 | 2024-03-01 | Buy |
Sigma-Aldrich | SML2163 | HPN-07 ≥98% (HPLC) | 168021-79-2 | 25mg | $264 | 2024-03-01 | Buy |
Cayman Chemical | 22109 | NXY-059 ≥98% | 168021-79-2 | 5mg | $48 | 2024-03-01 | Buy |
Cayman Chemical | 22109 | NXY-059 ≥98% | 168021-79-2 | 10mg | $89 | 2024-03-01 | Buy |
Cayman Chemical | 22109 | NXY-059 ≥98% | 168021-79-2 | 25mg | $176 | 2024-03-01 | Buy |
1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT Chemical Properties,Uses,Production
Uses
Cerovive (NXY-059) is a novel nitrone, shows efficacious neuroprotective effects that prevents ischemic damage by trapping free radicals. Used as a spin-trap agent. It is a clinically tested antioxidant and depicts potency against Ischemic stress, Neuroprotection.
Uses
A free radical trapping compound
Biological Activity
Free radical trapping agent. Reduces infarct size and preserves brain function in several animal models of acute ischemic stroke. Neuroprotectant.
Biochem/physiol Actions
Originally characterized for its NO-mimicking activity in preventing peroxynitrite formation and in vivo neuroprotective efficacy in animal models of cerebral ischemia (100 mg/kg i.v. in rabbits; 30-60 mg/kg plus 30-60 mg/kg/h i.v. or 50 mg/kg plus 8.8 mg/kg/h s.c. in rats; 28 mg/kg plus 16 mg/kg/h i.v. in monkeys), OKN-007 (HPN-07, NXY-059) is an orally available α-phenyl-tert-butylnitrone (PBN) derivative that is also shown to exhibit sulfatase 2 (SULF2) inhibitory activity and anticancer efficacy both in cultures (effective conc. 170-200 μM in Huh7 heptoma cultures) and in several rodent glioma models in vivo (C6, RG2, and GL261; 75 mg/kg/day for rats and 168 mg/kg/day for mice via drinking water).
References
[1] kuroda s1, tsuchidate r, smith ml, maples kr, siesjö bk.
1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT Suppliers
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CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
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