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ChemicalBook >> CAS DataBase List >>5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]-

5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]-

5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]- Structure
5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]- structure
CAS No.
2739844-28-9
Chemical Name:
5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]-
Synonyms
HPK1-IN-4;4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]-5-Pyrimidinecarboxamide;5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]-
CBNumber:
CB110689953
Molecular Formula:
C23H26N6O3
Molecular Weight:
434.49
MDL Number:
MOL File:
2739844-28-9.mol
Last updated:2024-07-02 08:54:58
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5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]- Properties

Boiling point 694.9±65.0 °C(Predicted)
Density 1.347±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
form Solid
pka 13.93±0.50(Predicted)
color Off-white to light yellow

5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]- Chemical Properties,Uses,Production

Biological Activity

HPK1-IN-4 (comp 22) is a HPK1 (MAPK41) inhibitor (IC50 of 0.061 nM) as preclinical immunotherapy tool compound[1].

References

[1]. Brandon A Vara, et al. Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds. ACS Med Chem Lett. 2021 Mar 19;12(4):653-661.

5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]- Suppliers

Global( 12)Suppliers
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32760 60
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4197 55
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9874 58
Shanghai Star Pharmaceutical Chemical Technology Co., Ltd. 021-58521787 17701827760 starpharmsh@gmail.com China 208 58
Shenyang Maud Pharmaceutical Technology Co., Ltd. 024-23982345 1020788318@qq.com China 2254 58
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822 czbjpharma@126.com China 18488 58
Suzhou Zhixin Biotechnology Co., Ltd. 0512-65118909 15162312715 sales@szzxbio.com China 2992 58
Suzhou Haiben Pharmaceutical Co., Ltd 14760821013 14760821013 1816280386@qq.com China 5409 58
EVERGREEN BIO-PHARM CO., LTD 13522905323 sales@hxybio.com China 341 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Aladdin Scientific 		58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai Chaolan Chemical Technology Center 58
Shanghai Star Pharmaceutical Chemical Technology Co., Ltd. 58
Shenyang Maud Pharmaceutical Technology Co., Ltd. 58
Changzhou Bojia Biomedical Technology Co., Ltd. 58
Suzhou Zhixin Biotechnology Co., Ltd. 58
Suzhou Haiben Pharmaceutical Co., Ltd 58
EVERGREEN BIO-PHARM CO., LTD 58
5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]- HPK1-IN-4 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]-5-Pyrimidinecarboxamide 2739844-28-9