ChemicalBook >> CAS DataBase List >>5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]-
5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]-
![5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]- Structure](CAS/20210305/GIF/2739844-28-9.gif)
- CAS No.
- 2739844-28-9
- Chemical Name:
- 5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]-
- Synonyms
- HPK1-IN-4;4-{[2-(hydroxymethyl)phenyl]amino}-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide;4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]-5-Pyrimidinecarboxamide;5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]-
- CBNumber:
- CB110689953
- Molecular Formula:
- C23H26N6O3
- Molecular Weight:
- 434.49
- MDL Number:
- MOL File:
- 2739844-28-9.mol
Last updated:2024-07-02 08:54:58
5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]- Properties
| Boiling point | 694.9±65.0 °C(Predicted) |
|---|---|
| Density | 1.347±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| form | Solid |
| pka | 13.93±0.50(Predicted) |
| color | Off-white to light yellow |
5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]- Chemical Properties,Uses,Production
Biological Activity
HPK1-IN-4 (comp 22) is a HPK1 (MAPK41) inhibitor (IC50 of 0.061 nM) as preclinical immunotherapy tool compound[1].
References
[1]. Brandon A Vara, et al. Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds. ACS Med Chem Lett. 2021 Mar 19;12(4):653-661.
5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]- Preparation Products And Raw materials
Raw materials
Preparation Products
5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]- Suppliers
Global( 11)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4512 | 55 | |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 7267 | 58 |
| Shanghai Star Pharmaceutical Chemical Technology Co., Ltd. | 021-58521787 17701827760 | starpharmsh@gmail.com | China | 208 | 58 |
| Shenyang Maud Pharmaceutical Technology Co., Ltd. | 024-23982345 | 1020788318@qq.com | China | 2251 | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18478 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24647 | 58 |
| Suzhou Haiben Pharmaceutical Co., Ltd | 14760821013 13564957716 | 1816280386@qq.com | China | 7522 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11974 | 58 |
5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]-
HPK1-IN-4
4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]-5-Pyrimidinecarboxamide
4-{[2-(hydroxymethyl)phenyl]amino}-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide
2739844-28-9