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ChemicalBook >> CAS DataBase List >>L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(10,10-dimethyl-3,8-dioxo-2,9-dioxa-4,7-diazaundec-1-yl)phenyl]-

L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(10,10-dimethyl-3,8-dioxo-2,9-dioxa-4,7-diazaundec-1-yl)phenyl]-

L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(10,10-dimethyl-3,8-dioxo-2,9-dioxa-4,7-diazaundec-1-yl)phenyl]- Structure
L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(10,10-dimethyl-3,8-dioxo-2,9-dioxa-4,7-diazaundec-1-yl)phenyl]- structure
CAS No.
1616727-22-0
Chemical Name:
L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(10,10-dimethyl-3,8-dioxo-2,9-dioxa-4,7-diazaundec-1-yl)phenyl]-
Synonyms
Mc-Val-Cit-PAB-NH-C2-NH-Boc;L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(10,10-dimethyl-3,8-dioxo-2,9-dioxa-4,7-diazaundec-1-yl)phenyl]-
CBNumber:
CB110810982
Molecular Formula:
C36H54N8O10
Molecular Weight:
758.86
MDL Number:
MOL File:
1616727-22-0.mol
Last updated:2024-07-02 08:54:58
Request For Quotation

L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(10,10-dimethyl-3,8-dioxo-2,9-dioxa-4,7-diazaundec-1-yl)phenyl]- Properties

Boiling point 1035.6±65.0 °C(Predicted)
Density 1.248±0.06 g/cm3(Predicted)
pka 12.11±0.46(Predicted)
form Solid
color White to off-white

L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(10,10-dimethyl-3,8-dioxo-2,9-dioxa-4,7-diazaundec-1-yl)phenyl]- Chemical Properties,Uses,Production

Biological Activity

MC-Val-Cit-PAB-NH-C2-NH-Boc is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

References

[1]. Akaiwa M, et al. Synthesis and Evaluation of Linear and Macrocyclic Dolastatin 10 Analogues Containing Pyrrolidine Ring Modifications. ACS Omega. 2018;3(5):5212-5221.

L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(10,10-dimethyl-3,8-dioxo-2,9-dioxa-4,7-diazaundec-1-yl)phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(10,10-dimethyl-3,8-dioxo-2,9-dioxa-4,7-diazaundec-1-yl)phenyl]- Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
ChemExpress 		+86-021-58950125 +86-021-58950125; info@chemexpress.com China 720 58
Shanghai Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 756 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19711 58
Supplier Advantage
ChemExpress 		58
Shanghai Haoyuan Chemexpress Co., Ltd. 58
TargetMol Chemicals Inc. 58
L-Ornithinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(10,10-dimethyl-3,8-dioxo-2,9-dioxa-4,7-diazaundec-1-yl)phenyl]- Mc-Val-Cit-PAB-NH-C2-NH-Boc 1616727-22-0