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2-(Di-tert-butylphosphino)biphenyl

2-(Di-tert-butylphosphino)biphenyl structure

CAS No.: 224311-51-7

Chemical Name:: 2-(Di-tert-butylphosphino)biphenyl

Synonyms: JohnPhos;ditert-butyl-(2-phenylphenyl)phosphane;2-(DI-T-BUTYLPHOSPHINO)BIPHENYL;(2-biphenyl)di-tert-butylphosphine;JnhnPhos;98% JohnPhos;JohnPhos 97%;2-(Di-t-butyL;CAS:224311-51-7;phosphino)biphenyL

CBNumber:: CB1108350

Molecular Formula:: C20H27P

Molecular Weight:: 298.4

MDL Number:: MFCD01862440

MOL File:: 224311-51-7.mol

MSDS File:: SDS

Last updated:2025-02-23 21:28:46

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2-(Di-tert-butylphosphino)biphenyl Properties

Melting point	86-88 °C (lit.)
Boiling point	405.5±24.0 °C(Predicted)
Density	1 g/cm³
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly, Heated, Sonicated)
form	Crystals or Crystalline Powder
color	White
Water Solubility	Insoluble
BRN	8322131
Stability	Air Sensitive
InChI	InChI=1S/C20H27P/c1-19(2,3)21(20(4,5)6)18-15-11-10-14-17(18)16-12-8-7-9-13-16/h7-15H,1-6H3
InChIKey	CNXMDTWQWLGCPE-UHFFFAOYSA-N
SMILES	P(C1=CC=CC=C1C1=CC=CC=C1)(C(C)(C)C)C(C)(C)C
CAS DataBase Reference	224311-51-7(CAS DataBase Reference)
FDA UNII	5Y743P380H
UNSPSC Code	12352002
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H413
Precautionary statements	P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes	Xn
Risk Statements	36/37/38-22
Safety Statements	36/37/39-26-22
WGK Germany	3
F	10-23
TSCA	No
HazardClass	AIR SENSITIVE
HS Code	29029090

2-(Di-tert-butylphosphino)biphenyl price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	638439	JohnPhos 97%	224311-51-7	1g	$61.3	2024-03-01	Buy
Sigma-Aldrich	638439	JohnPhos 97%	224311-51-7	5g	$291	2024-03-01	Buy
TCI Chemical	D3387	2-(Di-tert-butylphosphino)biphenyl >98.0%(GC)	224311-51-7	1g	$73	2024-03-01	Buy
TCI Chemical	D3387	2-(Di-tert-butylphosphino)biphenyl >98.0%(GC)	224311-51-7	5g	$301	2024-03-01	Buy
Strem Chemicals	15-1045	2-(Di-t-butylphosphino))-1,1'-biphenyl, 99% JohnPhos	224311-51-7	500mg	$29	2024-03-01	Buy

Product number	Packaging	Price	Buy
638439	1g	$61.3	Buy
638439	5g	$291	Buy
D3387	1g	$73	Buy
D3387	5g	$301	Buy
15-1045	500mg	$29	Buy

2-(Di-tert-butylphosphino)biphenyl Chemical Properties,Uses,Production

Reactions

Ligand used in the palladium-catalyzed synthesis of aromatic amines from aryl chlorides, bromides and triflates.
Ligand employed in a very active and general catalyst for Suzuki coupling reactions using aryl chlorides, bromides and triflates.
Ligand used in palladium-catalyzed synthesis of oxindoles from α-chloroacetanilides.
Effective ligand used in palladium-catalyzed arylation of thiazoles.
Used in the formation of 2-benzylindolines via sequential palladium-catalyzed N-arylation/cyclization/C-arylation.
Selective in the palladium-catalyzed arylation of silyl enol ethers formed from copper-catalyzed reduction of enones.

Chemical Properties

white to light yellow crystal powde

Uses

suzuki reaction

Uses

2-(Di-tert-butylphosphino)biphenyl (also known as JohnPhos) is a Buchwald ligand that is highly efficient in palladium-catalyzed reactions.

General Description

JohnPhos is a Buchwald′s sterically bulky biaryl phosphine ligand. It is a reactive dialkylbiaryl phosphine ligand which catalyzes the carbon-nitrogen bond-forming reactions. Coordination chemistry of gold catalysts bearing JohnPhos as ligand has been investigated by NMR spectroscopy.

reaction suitability

reaction type: Cross Couplings
reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: C-X Bond Formation
reagent type: ligand
reaction type: Heck Reaction
reagent type: ligand
reaction type: Suzuki-Miyaura Coupling

2-(Di-tert-butylphosphino)biphenyl synthesis

Synthesis of 2-(Di-tert-butylphosphino)biphenyl from Di-tert-butylchlorophosphane and 2-Bromobiphenyl

2-(Di-tert-butylphosphino)biphenyl Preparation Products And Raw materials

Raw materials

Di-tert-butylchlorophosphane 2-Bromobiphenyl 2-BIPHENYLYLMAGNESIUM BROMIDE 0.5M IN

Preparation Products

2-(Di-tert-butylphosphino)biphenyl Suppliers

Global( 369)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
XINXIANG RUNYU MATERIAL CO., LTD.	+86-13592593621; +8613592593621	sales@runvmat.com	China	411	58
Henan Research New Materials Co., Ltd.	+8618903931531	sales018@researchvip.com	China	169	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531157085	abby@chuanghaibio.com	China	8808	58
Hebei Mujin Biotechnology Co.,Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12809	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	7906	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29730	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-+86-371-66670886	info@dakenam.com	China	19805	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
AB PharmaTech,LLC	323-480-4688	sales@acrospharmatech.com	United States	989	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29858	58

Supplier	Advantage
XINXIANG RUNYU MATERIAL CO., LTD.	58
Henan Research New Materials Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Mujin Biotechnology Co.,Ltd	58
Shanghai UCHEM Inc.	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
AB PharmaTech,LLC	55
career henan chemical co	58

View Lastest Price from 2-(Di-tert-butylphosphino)biphenyl manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-23	2-(Di-tert-butylphosphino)biphenyl 224311-51-7	US $0.00-0.00 / KG	1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-04-23	2-(Di-tert-butylphosphino)biphenyl 224311-51-7	US $0.00 / g	1g	99%；sales036@researchvip.com;18903931628;	100KG	Henan Research New Materials Co., Ltd.
2025-03-21	2-(Di-tert-butylphosphino)biphenyl 224311-51-7	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mujin Biotechnology Co.,Ltd

2-(Di-tert-butylphosphino)biphenyl
224311-51-7
US $0.00-0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

2-(Di-tert-butylphosphino)biphenyl
224311-51-7
US $0.00 / g
99%；sales036@researchvip.com;18903931628;
Henan Research New Materials Co., Ltd.

2-(Di-tert-butylphosphino)biphenyl
224311-51-7
US $0.00 / KG
99%
Hebei Mujin Biotechnology Co.,Ltd

2-(Di-tert-butylphosphino)biphenyl Spectrum

2-(Di-tert-butylphosphino)biphenyl(224311-51-7)¹HNMR 2-(Di-tert-butylphosphino)biphenyl(224311-51-7)³¹PNMR

224311-51-7(2-(Di-tert-butylphosphino)biphenyl)Related Search:

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Butylated Hydroxytoluene T-BUTYLPHOSPHINE Di-tert-butylphosphine TERT-BUTYLPHOSPHONIC ACID 2-(DI-T-BUTYLPHOSPHINO)-2'-METHYLBIPHENYL

2-DI-T-BUTYLPHOSPHINO-2'-(N,N-DIMETHYLAMINO)BIPHENYL (2-BIPHENYL)DI-TERT-BUTYLPHOSPHINE GOLD& RAC-2-(DI-T-BUTYLPHOSPHINO)-1,1'-BINAPHTHYL 2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL 2-DI-TERT-BUTYLPHOSPHINO-3,4,5,6-TETRAM&

2-(Di-tert-butylphosphino)biphenyl 2-(2'-DI-TERT-BUTYLPHOSPHINE)BIPHENYLPALLADIUM(II) ACETATE 2,2'-BIS(DI-TERT-BUTYLPHOSPHINO)BIPHENYL

1of4

(2-BIPHENYLYL)DI-TERT-BUTYLPHOSPHINE 2-(DI-TERT-BUTYLPHOSPHINO)BIPHENYL BIPHENYL-2-YL-DI-TERT-BUTYL-PHOSPHANE 2-(Di-t-butylphosphino)biphenyl,99%JohnPhos 2-(Di-t-butylphosphine) biphenyl PHOSPHINE, [1,1''-BIPHENYL]-2-YLBIS(1,1-DIMETHYLETHYL)- 2-(Di-tert-butylphosphino)-biphenyl, JohnPhos (2-Biphenylyl)di-tert-butylphosphine, 2-(Di-tert-butylphosphino)biphenyl, JohnPhos 2-(Di-tert-butylphosphino)biphenyl,99% (2-Biphenyl)di-tert-butylphosphine,(2-Biphenylyl)di-tert-butylphosphine, 2-(Di-tert-butylphosphino)biphenyl, JohnPhos 98% JohnPhos (2-Biphenylyl)di-tert-butylphosphine JohnPhos 2-(Di-tert-butylphosphino)biphenyl, 99% 500MG 2-(Di-tert-butylphosphiNA)biphenyl 2-(Di-t-butylphosphino)biphenyl, JohnPhos [1,1'-biphenyl]-2-yldi-tert-butylphosphine 2-(Di-t-butylphosphino)biphenyl,98% JohnPhos 2-(Di-tert-butylphosphino)biph 2-(Di-tert-butylphosphino)biphenyl (2-Biphenyl)di-tert-butylphosphine JohnPhos 97% 99% SynonyMs (2-Biphenyl)di-tert-butylphosphine 2-(Di-t-butylphosphino))-1,1'-biphenyl 2-[Bis(tert-butyl)phosphino]biphenyl 98% 2-(Di-t-butylphosphino)-1,1'- biphenyl (Johnphos) 2-[Bis(tert-butyl)phosphino]biphenyl 2-(Di-t-butylphosphino))-1,1'-biphenyl, 99% JohnPhos [1,1'-biphenyl]-2-yldi-tert-bu 2-(Di-t-butylphosphino) 2-(Di-tert-butylphosphino)biphenyl> 2-(Di-t-butyL phosphino)biphenyL 2-(Di-tert-butylphosphino)-1,1'-biphenyl (2-biphenyl)di-tert-butylphosphine 2-(DI-T-BUTYLPHOSPHINO)BIPHENYL JohnPhos JnhnPhos ditert-butyl-(2-phenylphenyl)phosphane 1,1'-Biphenyl]-2-ylbis(1,1-dimethylethyl)phosphine itert-butyl-(2-phenylphenyl)phosphane [1,1'-Biphenyl]-2-ylbis(1,1-dimethylethyl)phosphine 2- (di tert butyl phosphine) biphenyl 1,1'-biphenyl]-2-yldi-tert-butylphosphine Pyridaben Impurity 2 CAS:224311-51-7 224311-51-7 C20H27P C6H5C6H4PCCH332 Buchwald Ligands Catalysis and Inorganic Chemistry Phosphorus Compounds Achiral Phosphine Aryl Phosphine Buchwald Ligands Series Buchwald Ligands&Precatalysts organophosphine ligand Ligand Benzene derivatives Phosphines