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1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[4-(hydroxymethyl)-3-(phenylmethyl)-2(3H)-thiazolylidene]-, [N(Z)]-

1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[4-(hydroxymethyl)-3-(phenylmethyl)-2(3H)-thiazolylidene]-, [N(Z)]- structure

CAS No.: 2687970-96-1

Chemical Name:: 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[4-(hydroxymethyl)-3-(phenylmethyl)-2(3H)-thiazolylidene]-, [N(Z)]-

Synonyms: TDI-011536;(Z)-N-(3-Benzyl-4-(hydroxymethyl)thiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide;1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[4-(hydroxymethyl)-3-(phenylmethyl)-2(3H)-thiazolylidene]-, [N(Z)]-

CBNumber:: CB110980346

Molecular Formula:: C19H16N4O2S

Molecular Weight:: 364.42

MDL Number:

MOL File:: 2687970-96-1.mol

Last updated:2024-07-02 08:54:58

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1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[4-(hydroxymethyl)-3-(phenylmethyl)-2(3H)-thiazolylidene]-, [N(Z)]- Properties

Density	1.41±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
form	Solid
pka	12.30±0.40(Predicted)
color	White to off-white

1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[4-(hydroxymethyl)-3-(phenylmethyl)-2(3H)-thiazolylidene]-, [N(Z)]- Chemical Properties,Uses,Production

Description

TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration^[1].

TDI-011536 (3 µM; 24 h) reduces Yap phosphorylation and (3 µM; 5 days) induces proliferation of MÜller glia in human retinal organoids^[1].

Cell Proliferation Assay^[1]

TDI-011536 (200 mg/kg; i.p.; once) provides over 4 h of Lats inhibition in the liver, heart, and skin and reduces the amount of pYap for at least 4 h after injection in all three organs^[1].
TDI-011536 (100 mg/kg; i.p.; once daily for 2 or 3 days) shows proliferative effect on cardiomyocytes^[1].

1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[4-(hydroxymethyl)-3-(phenylmethyl)-2(3H)-thiazolylidene]-, [N(Z)]- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[4-(hydroxymethyl)-3-(phenylmethyl)-2(3H)-thiazolylidene]-, [N(Z)]- Suppliers

Global( 14)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
Shandong Jirun Biomedical Technology Co., Ltd.	0539-0539-8613587 17661611089	2639273505@qq.com	China	165	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4264	55
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9929	58
Shandong Chenxi Pharmaceutical Co., Ltd.	+86-0531-88803416 13153166250	sales@chemedpharma.com	China	177	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9412	58
Wuxi Donghe Pharmaceutical Technology Co., Ltd.	63313187 15358055255	63313187@qq.com	China	1968	58
Bide Pharmatech Ltd.	400-1647117 15221909166	product02@bidepharm.com	China	63720	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	23963	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Shandong Jirun Biomedical Technology Co., Ltd.	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
ShangHai Biochempartner Co.,Ltd	62
Shanghai Chaolan Chemical Technology Center	58
Shandong Chenxi Pharmaceutical Co., Ltd.	58
DC Chemicals	58
Wuxi Donghe Pharmaceutical Technology Co., Ltd.	58
Bide Pharmatech Ltd.	58
TargetMol Chemicals Inc.	58

1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[4-(hydroxymethyl)-3-(phenylmethyl)-2(3H)-thiazolylidene]-, [N(Z)]- TDI-011536 (Z)-N-(3-Benzyl-4-(hydroxymethyl)thiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide 2687970-96-1