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GNF2133 HCl

GNF2133 HCl Structure
GNF2133 HCl structure
CAS No.
2561414-57-9
Chemical Name:
GNF2133 HCl
Synonyms
GNF2133 HCl;GNF2133 hydrochloride
CBNumber:
CB111014716
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file
Last updated:2024-10-28 16:48:35
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GNF2133 HCl Properties

storage temp. Store at -20°C

GNF2133 HCl Chemical Properties,Uses,Production

Biological Activity

GNF2133 hydrochloride is a potent, selective and orally active DYRK1A inhibitor with IC50s of 0.0062, >50 μM for DYRK1A and GSK3β, respectively. GNF2133 hydrochloride shows good proliferation potency and efficacy on rat and human primary β-cell. GNF2133 hydrochloride significantly improves glucose disposal capacity and increases insulin secretion. GNF2133 hydrochloride has the potential for the research of type 1 diabetes[1]. GNF2133 hydrochloride (30 mg/kg; p.o.) shows good oral absorption with oral bioavailability of 22.3%[1].GNF2133 hydrochloride (30 mg/kg; p.o.; once a day for 5 days) shows the ability to proliferate β-cells in vivo[1].GNF2133 hydrochloride (3, 10, 30 mg/kg) significantly improves glucose disposal capacity and increased insulin secretion in RIP-DTA mice[1].Pharmacokinetic Parameters of GNF2133 hydrochloride in CD-1 mice[1]. plasma (iv) plasma (po) pancreas (po) CL (mL/min/kg)23.5Vss (L/kg)11AUC (h.nM)326810974144420 Cmax(nM)1977167513319tmax<(h)0.033.03.0Clast(nM)36.6191324t1/2<(h)6.63.46.6F (%)22.3CD-1 mice; 30 mg/kg; p.o.sup>[1].

References

[1]. Liu YA, et al. Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133. J Med Chem. 2020 Mar 26;63(6):2958-2973.

GNF2133 HCl Preparation Products And Raw materials

Raw materials

Preparation Products

GNF2133 HCl Suppliers

Global( 4)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19885 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551 15151849396@163.com China 994 58
Shanghai Tachizaki Biomedical Research Center 18014399201 sales@chemlab-tachizaki.com China 2565 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19707 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 58
Shanghai Tachizaki Biomedical Research Center 58
TargetMol Chemicals Inc. 58

View Lastest Price from GNF2133 HCl manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GNF2133 hydrochloride pictures 2024-10-28 GNF2133 hydrochloride
2561414-57-9
 US $1990.00-3230.00 / mg 10g TargetMol Chemicals Inc.
GNF2133 HCl GNF2133 hydrochloride 2561414-57-9