NORFLUOXETINE HYDROCHLORIDE
- CAS No.
- 57226-68-3
- Chemical Name:
- NORFLUOXETINE HYDROCHLORIDE
- Synonyms
- NORFLUOXETINE HCL;Fluoxetine EP Impurity H;NORFLUOXETINE HYDROCHLORIDE;Fluoxetine Impurity 8(EP-H);Norfluoxetine hydrochloride in methanol;Norfluoxetine Hydrochloride Solution, 100ppm;Fluoxetine Impurity 8(Fluoxetine EP Impurity H);Norfluoxetine hydrochloride (Desmethylfluoxetine);3-PHENYL-3-(4-TRIFLUOROMETHYL-PHENOXY)-PROPYLAMINE HYDROCHLORIDE;3-[4-(TRIFLUOROMETHYL)PHENOXY]-3-PHENYLPROPAN-1-AMINE HYDROCHLORIDE
- CBNumber:
- CB1112230
- Molecular Formula:
- C16H17ClF3NO
- Molecular Weight:
- 331.76
- MDL Number:
- MFCD01321043
- MOL File:
- 57226-68-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| WGK Germany | 3 |
NORFLUOXETINE HYDROCHLORIDE price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 15900 | Norfluoxetine (hydrochloride) | 57226-68-3 | 1mg | $45 | 2024-03-01 | Buy |
| Cayman Chemical | 15900 | Norfluoxetine (hydrochloride) | 57226-68-3 | 10mg | $277 | 2024-03-01 | Buy |
| Cayman Chemical | 15900 | Norfluoxetine (hydrochloride) | 57226-68-3 | 5mg | $198 | 2024-03-01 | Buy |
| TRC | N681100 | Norfluoxetine hydrochloride | 57226-68-3 | 2mg | $100 | 2021-12-16 | Buy |
| AK Scientific | 4422AJ | Norfluoxetine hydrochloride | 57226-68-3 | 5mg | $98 | 2021-12-16 | Buy |
NORFLUOXETINE HYDROCHLORIDE Chemical Properties,Uses,Production
Description
Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A. Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15 nM). It has been found in the tissues of fish exposed to wastewater effluent.
Chemical Properties
NORFLUOXETINE HYDROCHLORIDE is Light Beige to Light Brown Solid
Uses
Norfluoxetine hydrochloride has been used to examine if psychoactive pharmaceuticals in drinking water at environmental concentrations could induce neuronal gene expression. It has also been used to examine whether at environmental concentrations it can alter in vitro expression of autism spectrum disorders (ASD)-associated synaptic proteins in human neurons.
Uses
Norfluoxetine Hydrochloride is a metabolite of Fluoxetine (F597100), a selective serotonin reuptake inhibitor which is used as an antidepressant.
Biochem/physiol Actions
Norfluoxetine is an active metabolite of fluoxetine. It disturbs the production of estrogen in a co-culture model of the feto-placental unit.
References
1) Veerman?et al.?(2013),?Slow delayed rectifier potassium current blockade contributes importantly to drug-induced long QT syndrome;?Circ. Arrythm. Electrophysiol.?6?1002 2) Lutz?et al.?(2013),?Stereoselective inhibition of CYP2C1 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems;?Drug Metab. Dispos.?41?2056 3) Wong?et al.?(1993),?Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain;?Neuropsychopharmacology?8?337 4) Zuo?et al.?(2012),?Fluoxetine is a potent inhibitor of coxsackievirus replication.; Antimicrob. Agents Chemother.?56?4838 5) McClenaghan?et al.?(2016),?Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states; J. Gen. Physiol.?147?497
NORFLUOXETINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Allfluoro pharmaceutical co. ltd. | 021-26137118 +8615821363818 | sales@allfluoro.com | China | 5790 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11922 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94657 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32321 | 50 |
View Lastest Price from NORFLUOXETINE HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Norfluoxetine Hydrochloride
57226-68-3
|
US $41.00-166.00 / mg | 99.75% | 10g | TargetMol Chemicals Inc. |
-
- Norfluoxetine Hydrochloride
57226-68-3
- US $41.00-166.00 / mg
- 99.75%
- TargetMol Chemicals Inc.
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