Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[3-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-4-[(methylsulfonyl)amino]-
- CAS No.
- 2600559-20-2
- Chemical Name:
- Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[3-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-4-[(methylsulfonyl)amino]-
- Synonyms
- KIF18A-IN-2;Inhibitor,Mitotic,Microtubule,Cancer,OVCAR-3,KIF18A,Microtubule/Tubulin,KIF18A IN 2,inhibit,KIF18AIN2,Tubulin;Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[3-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-4-[(methylsulfonyl)amino]-
- CBNumber:
- CB111464575
- Molecular Formula:
- C25H34N4O5S2
- Molecular Weight:
- 534.69
- MDL Number:
- MOL File:
- 2600559-20-2.mol
Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[3-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-4-[(methylsulfonyl)amino]- Chemical Properties,Uses,Production
Biological Activity
KIF18A-IN-2 is a potent KIF18A inhibitor (IC50=28 nM). KIF18A-IN-2 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-2 can be used for researching cancer[1]. KIF18A-IN-2 (compound 23) (100 mg/kg; i.p., single) exhibits a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours[1].Pharmacokinetic Parameters of KIF18A-IN-2 in female CD-1 mice[1]. IP (100 mg/kg) Cmax (μM)12.6AUC0-24 (μM.h)147 C24h (μM)2.9PPB (fu)0.007
References
[1]. Tamayo NA, et al. Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe. J Med Chem. 2022;65(6):4972-4990.
Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[3-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-4-[(methylsulfonyl)amino]- Preparation Products And Raw materials
Raw materials
Preparation Products
Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[3-[[(1,1-dimethylethyl)amino]sulfonyl]phenyl]-4-[(methylsulfonyl)amino]- Suppliers
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ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32835 | 60 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
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TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24648 | 58 |
Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 7416 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11975 | 58 |
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RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9268 | 58 |
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