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Dihydrodaidzein

CAS No.
17238-05-0
Chemical Name:
Dihydrodaidzein
Synonyms
Dihydrodaidzein>DIHYDRODAIDZEIN hplc;Dihydrodaidzein standard;7-hydroxy-3-(4-hydroxyphenyl)chroman-4-one;7-Hydroxy-3-(4-hydroxyphenyl)-4-chromanone;7-hydroxy-3-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one;inhibit,Endogenous Metabolite,Dihydrodaidzein,Inhibitor;2,3-Dihydro-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-3-(4-hydroxyphenyl)-;2,3-Dihydro-7-hydroxy-3-(4-hydroxyphenyl)-4H-1- benzopyran-4-one,99%e.e.
CBNumber:
CB11176286
Molecular Formula:
C15H12O4
Molecular Weight:
256.25
MDL Number:
MFCD00210494
MOL File:
17238-05-0.mol
MSDS File:
SDS
Last updated:2024-11-20 11:41:24

Dihydrodaidzein Properties

Melting point 250-251°C
Boiling point 529.5±50.0 °C(Predicted)
Density 1.386±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer, Under Inert Atmosphere
solubility ≤0.1mg/ml in ethanol;30mg/ml in DMSO;10mg/ml in dimethyl formamide
pka 7.71±0.40(Predicted)
form powder to crystal
color Light orange to Yellow to Green
λmax 313nm(EtOH aq.)(lit.)
CAS DataBase Reference 17238-05-0

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313
HS Code  2932990090
NFPA 704
0
2 0

Dihydrodaidzein price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SMB00944 Dihydrodaidzein ≥95% 17238-05-0 10MG $176 2024-03-01 Buy
Sigma-Aldrich SMB00944 Dihydrodaidzein ≥95% 17238-05-0 50MG $410 2024-03-01 Buy
TCI Chemical D4239 Dihydrodaidzein >93.0%(HPLC) 17238-05-0 25mg $313 2024-03-01 Buy
Cayman Chemical 17423 Dihydrodaidzein ≥98% 17238-05-0 5mg $44 2024-03-01 Buy
Cayman Chemical 17423 Dihydrodaidzein ≥98% 17238-05-0 10mg $70 2024-03-01 Buy
Product number Packaging Price Buy
SMB00944 10MG $176 Buy
SMB00944 50MG $410 Buy
D4239 25mg $313 Buy
17423 5mg $44 Buy
17423 10mg $70 Buy

Dihydrodaidzein Chemical Properties,Uses,Production

Chemical Properties

Light Beige Needles

Uses

Daidzein is an isoflavonoid phytoestrogenic compound found in soybeans, pea pods, clover, kudzu, and other legumes. Dihydrodaidzein is an active, estrogenic metabolite of daidzein. It has vasodilatory action on rat isolated aortic rings at 1 μg/ml. It stimulates the estrogen receptor-dependent growth of breast cancer MCF-7 cells at micromolar concentrations. Dihydrodaidzein is produced by the metabolism of daidzein in colonic bacteria and may be further metabolized to various bioactive compounds, including equol .

Uses

A metabolite of Daidzein.

Definition

ChEBI: A hydroxyisoflavanone that is isoflavanone carrying two hydroxy substituents located at positions 4' and 7.

Biological Activity

dihydrodaidzein, an active, estrogenic metabolite of daidzein in colonic bacteria, probably is further metabolized to various bioactive compounds including equol. as an estrogen receptor agonist, dihydrodaidzein, at micromolar concentrations, activates the estrogen receptor-dependent growth of breast cancer cells. daidzein, an isoflavonoid phytoestrogenic compound, is found in soybeans, clover, kudzu, and other legumes.

in vitro

prostatic fluid and plasma concentrations of dihydrodaidzein were sufficient to block the growth of benign human prostatic epithelial cells (prec). dihydrodaidzein showed a significant inhibitory effect on the growth of prostate cancer cell line lncap. additionally, dihydrodaidzein slightly triggered the apoptosis of prec. in addition to affecting apoptosis, dihydrodaidzein decreased proliferation, which was associated with the changes in cell cycle distribution and caspase 3 activation [1].

in vivo

male c57b1/6 wild type mice were administered orally with dihydrodaidzein at a dose of 25 mg/kg/day for 4 weeks. compared to the control groups, the neointima of mice treated with dihydrodaidzein was thickened. in dihydrodaidzein-treated mice, the intimal thickness in the non-injured right iliac artery was not altered. moreover, neointimal proliferation was selectively blocked by dihydrodaidzein via suppressing the migration and proliferation of vascular smooth muscle cell and dampening the endothelial apoptosis [2].

References

[1]. hedlund, t., bokhoven, a., johannes, w., nordeen, s., & ogden, l. prostatic fluid concentrations of isoflavonoids in soy consumers are sufficient to inhibit growth of benign and malignant prostatic epithelial cells in vitro. the prostate. 2006; 66(5): 557-566.
[2]. shen, j., white, m., husband, a., hambly, b., & bao, s. phytoestrogen derivatives differentially inhibit arterial neointimal proliferation in a mouse model. european journal of pharmacology. 2006; 548(1-3): 123-128.

Dihydrodaidzein Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 99)Suppliers
Supplier Tel Email Country ProdList Advantage
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897 sales@biopurify.com China 3772 58
Shanghai Standard Technology Co., Ltd.
18502101150 ft-sales@nature-standard.com CHINA 1923 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63687 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30239 58
Aktin Chemicals, Inc.
028-85159085 info@aktinchem.com CHINA 1025 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739 info@dycnchem.com China 52849 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
PT CHEM GROUP LIMITED
+86-85511178; +86-85511178; peter68@ptchemgroup.com China 35425 58

View Lastest Price from Dihydrodaidzein manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dihydrodaidzein pictures 2024-11-19 Dihydrodaidzein
17238-05-0
US $82.00 / mg 99.3% 10g TargetMol Chemicals Inc.
Dihydrodaidzein pictures 2023-02-24 Dihydrodaidzein
17238-05-0
US $0.00 / mg 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
  • Dihydrodaidzein pictures
  • Dihydrodaidzein
    17238-05-0
  • US $0.00 / mg
  • ≥98%(HPLC)
  • Shanghai Standard Technology Co., Ltd.
DIHYDRODAIDZEIN hplc 2,3-Dihydro-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 2,3-Dihydro-7-hydroxy-3-(4-hydroxyphenyl)-4H-1- benzopyran-4-one,99%e.e. 7-hydroxy-3-(4-hydroxyphenyl)chroman-4-one 7-hydroxy-3-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one Dihydrodaidzein> 4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-3-(4-hydroxyphenyl)- 7-Hydroxy-3-(4-hydroxyphenyl)-4-chromanone inhibit,Endogenous Metabolite,Dihydrodaidzein,Inhibitor Dihydrodaidzein standard 17238-05-0 inhibitor Heterocycles Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Iso-Flavones Various Metabolites and Impurities