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INDEX NAME NOT YET ASSIGNED

INDEX NAME NOT YET ASSIGNED Structure
INDEX NAME NOT YET ASSIGNED structure
CAS No.
2649530-57-2
Chemical Name:
INDEX NAME NOT YET ASSIGNED
Synonyms
4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-((2S,3S)-2-hydroxypentan-3-yl-4,4,5,5,5-d5)-2,4-dihydro-3H-1,2,4-triazol-3-one
CBNumber:
CB112195872
Molecular Formula:
C37H42F2N8O4
Molecular Weight:
700.79
MDL Number:
MOL File:
2649530-57-2.mol
Last updated:2023-04-23 13:52:06
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INDEX NAME NOT YET ASSIGNED Properties

solubility Acetonitrile: soluble
form A solid

INDEX NAME NOT YET ASSIGNED price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22376 Posaconazole-d5 ≥98% deuterated forms (d1-d5) 2649530-57-2 500 μg $436 2024-03-01 Buy
Cayman Chemical 22376 Posaconazole-d5 ≥98% deuterated forms (d1-d5) 2649530-57-2 1 mg $785 2024-03-01 Buy
Product number Packaging Price Buy
22376 500 μg $436 Buy
22376 1 mg $785 Buy

INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production

Description

Posaconazole-d5 is intended for use as an internal standard for the quantification of posaconazole by GC- or LC-MS. Posaconazole is a broad-spectrum triazole antifungal agent active against various yeasts and molds, including Aspergillus, Candida, Fusarium, and Zygomycetes.1 Posaconazole inhibits the growth of fungi by inhibiting the lanosterol 14α-demethylase enzyme (IC50s = 7-200 nM), which results in a disruption in the synthesis of ergosterol , a key sterol necessary for fungal cell membrane integrity and for the function of certain membrane-bound proteins.2

References

1. Herbrecht, R., Nivoix, Y., Fohrer, C., et al. Management of systemic fungal infections: Alternatives to itraconazole J. Antimicrob. Chemother. 56(Suppl 1),i39-i48(2005).
2. Munayyer, H.K., Mann, P.A., Chau, A.S., et al. Posaconazole is a potent inhibitor of sterol 14α-demethylation in yeasts and molds Antimicrob. Agents Chemother. 48(10),3690-3696(2004).

INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials

Raw materials

Preparation Products

INDEX NAME NOT YET ASSIGNED Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
LGC Science (Shanghai) Ltd. 17717235263 cindy.yang@lgcgroup.com China 11677 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11975 58
Supplier Advantage
LGC Science (Shanghai) Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-((2S,3S)-2-hydroxypentan-3-yl-4,4,5,5,5-d5)-2,4-dihydro-3H-1,2,4-triazol-3-one