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Fmoc-VC-PAB-Eribulin

CAS No.
Chemical Name:
Fmoc-VC-PAB-Eribulin
Synonyms
Fmoc-VC-PAB-Eribulin
CBNumber:
CB112281542
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file
Last updated:2023-10-11 09:57:11

Fmoc-VC-PAB-Eribulin Chemical Properties,Uses,Production

Uses

Fmoc-VC-PAB-Eribulin is an Antibody-drug Conjugate (ADC) that can specifically recognize and kill target cancer cells without harming the organism, resulting in minimal toxic side effects. It is composed of an antibody, an ADC Cytotoxin (payload), and a Linker that connects these two components. Valine-citrulline (Val-Cit) is an amino acid unit often found in cleavable peptide fragments in the connectome. Eribulin, on the other hand, is a structurally simplified and fully synthetic analog of macrocyclic ketone halichondrin B. In 2010, the FDA approved eribulin for the treatment of metastatic breast cancer (MBC). Eribulin acts as a microtubule dynamics inhibitor and also exhibits tumor microenvironment modulation activities, such as vascular remodeling activity [1-2].

References

[1] Yu Q, et al. Gram-Scale Synthesis of the C14–C23 Fragment of Eribulin. Organic Process Research & Development, 2023; 27: 367–372.
[2] Niwa Y, et al. Liposome-Encapsulated Eribulin Shows Enhanced Antitumor Activity over Eribulin for Combination Therapy with Anti–PD-1 Antibody. Molecular Cancer Therapeutics, 2023; 2: 499–510.

Fmoc-VC-PAB-Eribulin Preparation Products And Raw materials

Raw materials

Preparation Products

Fmoc-VC-PAB-Eribulin Suppliers

Global( 1)Suppliers
Supplier Tel Email Country ProdList Advantage
Xilinglab Co., Ltd.
+8618381337976 bd@xilinglab.com China 86 58
Supplier Advantage
Xilinglab Co., Ltd.
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Fmoc-VC-PAB-Eribulin