ChemicalBook >> CAS DataBase List >>2-Quinazolinecarboxamide, N-methyl-4-[[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]amino]-

2-Quinazolinecarboxamide, N-methyl-4-[[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]amino]-

2-Quinazolinecarboxamide, N-methyl-4-[[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]amino]- structure

CAS No.: 2439096-06-5

Chemical Name:: 2-Quinazolinecarboxamide, N-methyl-4-[[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]amino]-

Synonyms: VEGFR-2-IN-26;2-Quinazolinecarboxamide, N-methyl-4-[[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]amino]-

CBNumber:: CB112741989

Molecular Formula:: C24H19F3N6O2

Molecular Weight:: 480.44

MDL Number:

MOL File:: 2439096-06-5.mol

Last updated:2025-04-18 09:51:36

Request For Quotation

2-Quinazolinecarboxamide, N-methyl-4-[[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]amino]- Properties

Density	1.454±0.06 g/cm3(Predicted)
pka	10.99±0.46(Predicted)

2-Quinazolinecarboxamide, N-methyl-4-[[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]amino]- Chemical Properties,Uses,Production

Uses

VEGFR-2-IN-26 (compound 5h) is a highly potent VEGFR-2 inhibitor with an IC50 value of 15.5 nM. VEGFR-2-IN-26 has good antiproliferative activity against the leukemic, non-small lung, CNS, ovarian, renal, prostate and breast cancer cells[1].

IC 50

VEGFR-2: 15.5 nM (IC₅₀)

References

[1] Hadi SRAE, et al. Scaffold hopping and redesign approaches for quinazoline based urea derivatives as potent VEGFR-2 inhibitors. Bioorg Chem. 2020 Aug;101:103961. DOI:10.1016/j.bioorg.2020.103961

2-Quinazolinecarboxamide, N-methyl-4-[[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Quinazolinecarboxamide, N-methyl-4-[[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]amino]- Suppliers

Global( 1)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19784	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

2-Quinazolinecarboxamide, N-methyl-4-[[4-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]amino]- VEGFR-2-IN-26 2439096-06-5