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BMS 186511
- CAS No.
- 167467-53-0
- Chemical Name:
- BMS 186511
- Synonyms
- BMS 186511;L-Methionine, N-[3-[hydroxy[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrienyl]phosphinyl]-1-oxopropyl]-L-valyl-L-valyl-, methyl ester (9CI)
- CBNumber:
- CB11372796
- Molecular Formula:
- C34H60N3O7PS
- Molecular Weight:
- 685.89
- MDL Number:
- MOL File:
- 167467-53-0.mol
Last updated:2023-03-31 09:12:58
BMS 186511 Chemical Properties,Uses,Production
Description
BMS-186511 is a Farnesyltransferase (FT) inhibitor with potential anticancer activity. BMS-186511 is a bisubstrate analogue inhibitor of FT, would inhibit the malignant growth properties of a cell line established from malignant schwannoma of an NF1 patient. Following treatment with BMS-186511 , ST88-14 cells became flat, nonrefractile, were contact-inhibited, and lost their ability to grow in soft agar. BMS-186511 was found to specifically inhibit FT, but not geranylgeranyltransferase I, a closely related enzyme. Thus, it is conceivable that FT inhibitors may ultimately become the first generation of drugs against the malignant phenotype in NF1 based on rational insights into the mechanism of action of neurofibromin.
BMS 186511 Preparation Products And Raw materials
Raw materials
Preparation Products
BMS 186511 Suppliers
Global( 1)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28118 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
BMS 186511
L-Methionine, N-[3-[hydroxy[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrienyl]phosphinyl]-1-oxopropyl]-L-valyl-L-valyl-, methyl ester (9CI)
167467-53-0