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PHD-IN-3

PHD-IN-3 structure

CAS No.: 2924181-77-9

Chemical Name:: PHD-IN-3

Synonyms: PHD-IN-3;1,7-Naphthyridine-6-carboxamide, N-[(6-cyano-3-pyridinyl)methyl]-5-hydroxy-2-[(3R)-3-hydroxy-1-pyrrolidinyl]-

CBNumber:: CB113900493

Molecular Formula:: C20H18N6O3

Molecular Weight:: 390.4

MDL Number:

MOL File:: 2924181-77-9.mol

Last updated:2025-04-18 09:51:41

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PHD-IN-3 Properties

Boiling point	870.7±65.0 °C(predicted)
Density	1.52±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka	3.36±0.50(predicted)

PHD-IN-3 Chemical Properties,Uses,Production

Uses

PHD-IN-3 (Compound 15) is an orally active PHD inhibitor. PHD-IN-3 can be used in the study of anemia associated with chronic kidney disease[1].

References

[1] Xu J, et al. Discovery of Novel and Potent Prolyl Hydroxylase Domain-Containing Protein (PHD) Inhibitors for The Treatment of Anemia. J Med Chem. 2024 Jan 8. DOI:10.1021/acs.jmedchem.3c01932

PHD-IN-3 Preparation Products And Raw materials

Raw materials

Preparation Products

PHD-IN-3 1,7-Naphthyridine-6-carboxamide, N-[(6-cyano-3-pyridinyl)methyl]-5-hydroxy-2-[(3R)-3-hydroxy-1-pyrrolidinyl]- 2924181-77-9