BGP 15
- CAS No.
- 951628-79-8
- Chemical Name:
- BGP 15
- Synonyms
- BGP 15
- CBNumber:
- CB11399766
- Molecular Formula:
- C14H23ClN4O2
- Molecular Weight:
- 314.81
- MDL Number:
- MFCD21603901
- MOL File:
- 951628-79-8.mol
| Melting point | >177°C (dec.) |
|---|---|
| storage temp. | -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Pale Yellow to Pale Beige |
| FDA UNII | RLN2GTG4YS |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Symbol(GHS) | GHS06 |
| Signal word | Danger |
| Signal word | Danger |
| Hazard statements | H301 |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P405-P501 |
| Precautionary statements | P264-P270-P301+P310-P405-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
BGP 15 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B4813 | BGP-15 ≥98% (HPLC) | 951628-79-8 | 5MG | $170 | 2023-06-20 | Buy |
| Sigma-Aldrich | B4813 | BGP-15 ≥98% (HPLC) | 951628-79-8 | 25MG | $682 | 2023-06-20 | Buy |
| Tocris | 6703 | BGP15 ≥98%(HPLC) | 951628-79-8 | 5 | $115 | 2021-12-16 | Buy |
| Tocris | 6703 | BGP15 ≥98%(HPLC) | 951628-79-8 | 25 | $449 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb545890 | bGP-15 >98% | 951628-79-8 | 25mg | $654.5 | 2021-12-16 | Buy |
BGP 15 Chemical Properties,Uses,Production
Uses
BGP 15 is a calcipotriene-based vitamin D3 analog that inhibits poly(ADP-ribose) polymerasesis (PARP), a class of enzymes that regulate DNA repair and apoptosis (1). BGP 15 is also a cardioprotective agent (2). Also, BPG 15 improves mitochondrial function, protects neurons from dying in vitro and in vivo, and promotes cardiac innervation in vivo.
Uses
BGP-15 has been used to study its influence on proteasomal degradation of missense dystrophins.
General Description
BGP-15 is a hydroxylamine derivative, which has cytoprotective and neuroprotective properties. It reduces phospho- c-Jun N-terminal kinase (pJNK) and p38 stress signalling. BGP-15 also stimulates non-specific serine/threonine protein kinase (AKT) and insulin-like growth factor 1 receptor (IGFR1) protective signalling. BGP-15 functions as an insulin sensitizer in an olanzapine-induced metabolic disorder. It protects cells against cell death and enhances the expression of heat shock protein (HSP). BGP-15 might be used to treat heart failure (HF) and atrial fibrillation (AF).
Biochem/physiol Actions
BGP-15 is PARP inhibitor, HSP72 activator.
BGP 15 Preparation Products And Raw materials
Raw materials
Preparation Products
BGP 15 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |