ChemicalBook >> CAS DataBase List >>(R)-5-methyl-3-(5-((1-oxo-1-(6-azaspiro[2.5]octan-6-yl)propan-2-yl)amino)-1,3,4-oxadiazol-2-yl)-6-(trifluoromethyl)pyridin-2(1H)-one

(R)-5-methyl-3-(5-((1-oxo-1-(6-azaspiro[2.5]octan-6-yl)propan-2-yl)amino)-1,3,4-oxadiazol-2-yl)-6-(trifluoromethyl)pyridin-2(1H)-one

(R)-5-methyl-3-(5-((1-oxo-1-(6-azaspiro[2.5]octan-6-yl)propan-2-yl)amino)-1,3,4-oxadiazol-2-yl)-6-(trifluoromethyl)pyridin-2(1H)-one structure

CAS No.: 3038770-25-8

Chemical Name:: (R)-5-methyl-3-(5-((1-oxo-1-(6-azaspiro[2.5]octan-6-yl)propan-2-yl)amino)-1,3,4-oxadiazol-2-yl)-6-(trifluoromethyl)pyridin-2(1H)-one

Synonyms: (R)-5-methyl-3-(5-((1-oxo-1-(6-azaspiro[2.5]octan-6-yl)propan-2-yl)amino)-1,3,4-oxadiazol-2-yl)-6-(trifluoromethyl)pyridin-2(1H)-one;2(1H)-Pyridinone, 3-[5-[[(1R)-2-(6-azaspiro[2.5]oct-6-yl)-1-methyl-2-oxoethyl]amino]-1,3,4-oxadiazol-2-yl]-5-methyl-6-(trifluoromethyl)-

CBNumber:: CB114300449

Molecular Formula:: C19H22F3N5O3

Molecular Weight:: 425.41

MDL Number:

MOL File:: 3038770-25-8.mol

Last updated:2025-04-17 18:22:24

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(R)-5-methyl-3-(5-((1-oxo-1-(6-azaspiro[2.5]octan-6-yl)propan-2-yl)amino)-1,3,4-oxadiazol-2-yl)-6-(trifluoromethyl)pyridin-2(1H)-one Properties

Density	1.43±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka	5.27±0.10(predicted)

(R)-5-methyl-3-(5-((1-oxo-1-(6-azaspiro[2.5]octan-6-yl)propan-2-yl)amino)-1,3,4-oxadiazol-2-yl)-6-(trifluoromethyl)pyridin-2(1H)-one Chemical Properties,Uses,Production

Uses

TMEM175 modulator 1 (compound 47) is a modulator of TMEM175 with an EC50 of 60 nM[1].

References

[1] Synthesis of azaspiro heterocylic prodrugs as transmembrane protein modulators treating cancers, neurodegenerative, inflammatory, or lysosomal storage disorders. World Intellectual Property Organization, WO2024108155 A2. 2024-05-23.

(R)-5-methyl-3-(5-((1-oxo-1-(6-azaspiro[2.5]octan-6-yl)propan-2-yl)amino)-1,3,4-oxadiazol-2-yl)-6-(trifluoromethyl)pyridin-2(1H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-5-methyl-3-(5-((1-oxo-1-(6-azaspiro[2.5]octan-6-yl)propan-2-yl)amino)-1,3,4-oxadiazol-2-yl)-6-(trifluoromethyl)pyridin-2(1H)-one Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Birdo (Shanghai) Medical Technology Co., Ltd.	021-58099077-8041 18601625411	sales@birdotech.com	China	9729	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	15000803246 18149758185	sales-cpd@caerulumpharma.com	China	344	58

Supplier	Advantage
Birdo (Shanghai) Medical Technology Co., Ltd.	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	58

(R)-5-methyl-3-(5-((1-oxo-1-(6-azaspiro[2.5]octan-6-yl)propan-2-yl)amino)-1,3,4-oxadiazol-2-yl)-6-(trifluoromethyl)pyridin-2(1H)-one 2(1H)-Pyridinone, 3-[5-[[(1R)-2-(6-azaspiro[2.5]oct-6-yl)-1-methyl-2-oxoethyl]amino]-1,3,4-oxadiazol-2-yl]-5-methyl-6-(trifluoromethyl)- 3038770-25-8