1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride
![1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride Structure](CAS/GIF/84484-78-6.gif)
- CAS No.
- 84484-78-6
- Chemical Name:
- 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride
- Synonyms
- BTS 54-505;Sibutramine Impurity 1;BTS 54-505 hydrochloride;N-DI-DESMETHYL SIBUTRAMINE HCL;N,N-Didesmethyl Sibutramine HCl;Didesmethyl Sibutramine Hydrochloride;N-DI-DESMETHYL SIBUTRAMINE HYDROCHLORIDE;Sibutramine Hydrochloride Monohydrate EP Impurity G;1-[1-(4-CHLOROPHENYL)CYCLOBUTYL]-3-METHYLBUTYLAMINE HCL;N-[1-(4-chlorophenyl)cyclobutyl-3-methylbutyl)]hydrochloride
- CBNumber:
- CB1145568
- Molecular Formula:
- C15H23Cl2N
- Molecular Weight:
- 288.26
- MDL Number:
- MFCD03411585
- MOL File:
- 84484-78-6.mol
| Melting point | 160 - 166°C |
|---|---|
| storage temp. | Desiccate at RT |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
| CAS DataBase Reference | 84484-78-6(CAS DataBase Reference) |
| FDA UNII | XJH8PK8XYH |
1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 2322 | BTS54-505hydrochloride ≥99%(HPLC) | 84484-78-6 | 10 | $129 | 2021-12-16 | Buy |
| Tocris | 2322 | BTS54-505hydrochloride ≥99%(HPLC) | 84484-78-6 | 50 | $524 | 2021-12-16 | Buy |
| TRC | D441170 | DidesmethylSibutramineHydrochloride | 84484-78-6 | 5mg | $100 | 2021-12-16 | Buy |
| Usbiological | 163783 | Didesmethyl Sibutramine Hydrochloride | 84484-78-6 | 5mg | $460 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BRS0000106 | BTS 54-505 95.00% | 84484-78-6 | 1G | $490 | 2021-12-16 | Buy |
1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride Chemical Properties,Uses,Production
Biological Activity
Potently active primary amine metabolite of sibutramine (1-(4-Chlorophenyl)-N,N-dimethyl-a-(2-methylpropyl)cyclobutanemethanamine hydrochloride ) that exhibits a similar pharmacological profile to the parent compound. Inhibits serotonin and noradrenalin reuptake more potently than sibutramine in vitro . In vivo, reduces food intake in rodents following i.c.v. administration and increases energy expenditure via thermogenesis.
in vitro
simultaneous application of bts 54-505 with 5-ht resulted in a prolongation of the recovery time from the 5-ht-mediated suppression of discharge activity. bts 54-505 also prolonged the recovery time from a na-mediated potentiation of firing. these effects on recovery time are attributed to the inhibition of uptake of both 5-ht and na by bts 54-505. the amplitude of the response to 5-ht or na was unaffected by co-ejection of bts 54-505 [1].
in vivo
the secondary (bts 54-354) and primary (bts 54-505) amine metabolites of sibutramine hcl exhibit similar in vivo pharmacological activity to the parent compound. thus, each compound displays potent activity in acute behavioural models predictive of antidepressant effects and a comparable ability to inhibit the uptake of monoamines [2].
IC 50
0.066 μm for noradrenaline uptake; 5.1 μm for 5-ht uptake; 0.31 μm for dopamine uptake
References
[1] scott g, luscombe gp, mason r. the effects of bts 54-505, a metabolite of sibutramine, on monoamine and excitatory amino acid-evoked responses in the rat dorsolateral geniculate nucleus in vivo. br j pharmacol. 1994 jan;111(1):97-102.
[2] luscombe gp, hopcroft rh, thomas pc, buckett wr. the contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutramine hydrochloride. neuropharmacology. 1989 feb;28(2):129-34.
1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29811 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32343 | 55 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32321 | 50 |
View Lastest Price from 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride pictures](/ProductImageEN/2021-08/Small/61086aca-4e77-415d-951b-33613195d88a.jpg) |
2021-08-12 | 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride
84484-78-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
![1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride pictures](https://img.chemicalbook.com/ProductImageEN/2019-12/Small/b23a0ddd-da46-4e6c-967f-49a185ef2238.jpg) |
2019-12-25 | 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride
84484-78-6
|
US $1.00 / KG | 1KG | 98%HPLC | 10t | Career Henan Chemical Co |
-
- 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride
84484-78-6
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride
84484-78-6
- US $1.00 / KG
- 98%HPLC
- Career Henan Chemical Co
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