N-Methyl-L-proline
- CAS No.
- 475-11-6
- Chemical Name:
- N-Methyl-L-proline
- Synonyms
- N-METHYL-L-PROLINE;N-Methylproline;N-ME-PRO-OH;1-Methyl-L-proline;Hygric acid;N-ME-PROLINE;Hygrinic acid;N-Me-L-Pro-OH;PYRD(2)-OH H2O;H-MEPRO-OH H2O
- CBNumber:
- CB1179181
- Molecular Formula:
- C6H11NO2
- Molecular Weight:
- 129.16
- MDL Number:
- MFCD00011565
- MOL File:
- 475-11-6.mol
- MSDS File:
- SDS
Melting point | 114-116 °C(lit.) |
---|---|
Boiling point | 227℃ |
Density | 1.153 |
Flash point | 91.1℃ |
refractive index | 1.5000 |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
pka | 2.37±0.20(Predicted) |
form | Powder |
color | White to off-white |
Water Solubility | Soluble in water and methanol(both 50 mg/ml-clear-colorless solution) |
InChI | InChI=1S/C6H11NO2/c1-7-4-2-3-5(7)6(8)9/h5H,2-4H2,1H3,(H,8,9)/t5-/m0/s1 |
InChIKey | CWLQUGTUXBXTLF-YFKPBYRVSA-N |
SMILES | C(O)(=O)[C@@H]1CCCN1C |
CAS DataBase Reference | 475-11-6 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Hazard statements | H302-H315-H319-H332-H335 | |||||||||
Precautionary statements | P233-P260-P261-P264-P270-P271-P280-P301+P312-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501 | |||||||||
WGK Germany | 3 | |||||||||
HazardClass | IRRITANT | |||||||||
NFPA 704 |
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N-Methyl-L-proline price More Price(38)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | M8021 | N-Methyl-L-proline | 475-11-6 | 500mg | $489 | 2023-06-20 | Buy |
Sigma-Aldrich | M8021 | N-Methyl-L-proline | 475-11-6 | 1g | $844 | 2023-06-20 | Buy |
Alfa Aesar | H63241 | N-Methyl-L-proline, 98% | 475-11-6 | 1g | $347 | 2021-12-16 | Buy |
Alfa Aesar | H63241 | N-Methyl-L-proline, 98% | 475-11-6 | 250mg | $117 | 2021-12-16 | Buy |
Usbiological | 240080 | N-Methyl-L-proline, 98% | 475-11-6 | 250mg | $206 | 2021-12-16 | Buy |
N-Methyl-L-proline Chemical Properties,Uses,Production
Uses
N-Methyl-L-proline, is an aminoacid which is widely used in pharmaceuticals and food industry.
Definition
ChEBI: N-methylproline is an L-proline derivative obtained by replacement of the amino hydrogen by a methyl group. It has a role as a plant metabolite and a human metabolite. It is a L-proline derivative and a tertiary amino compound. It is a tautomer of a N-methylproline zwitterion.
Synthesis
L-Proline 86 (2.0 g, 17.4 mmol) was dissolved in methanol (20 mL) and to this solution was added 40% aqueous formaldehyde solution (1.4 mL, 19.1 mmol). This was followed by the addition of 10% palladiumon-charcoal catalyst (500 mg) and the resulting slurry was stirred in a hydrogen atmosphere overnight. The slurry was then filtered through a Celite pad to remove the catalyst. The pad was washed with methanol and the combined filtrates were concentrated under reduced pressure. The residue was taken up in ethanol-benzene (1:1, 100 mL) and concentrated a second time to provide a solid, which was recrystallized from methanol-diethyl ether. In this way N-Methyl-L-proline was isolated as fine needles (2.2 g, 98%). Mp 142-145 °C. [α]23 D -78.0° (c 2.0, MeOH). 1H NMR (300 MHz, D2O) δ 3.71-3.65 and 3.55-3.51 (2m, 1H), 3.00-2.91 (m, 1H), 2.74 (s, 3H), 2.34-2.28 (m, 1H), 1.99-1.78 (m, 3H). 13C NMR (75 MHz, CDCl3) δ 173.06, 70.18, 55.83, 40.26, 28.34, 22.37. IR (KBr disk) ν 3000-2800 (CH, saturated), 2675 and 2605 (ammonium ion), 1669 (CO2H), 1612 (CO2 -), 1468, 1401, 1354, 1327, 1234, 1183, 1112, 1056, 1025, 808, 775 cm-1. HRMS calcd for C6H11NO2 (M+) 129.0790, found 129.0784.
N-Methyl-L-proline Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shaanxi Dideu Medichem Co. Ltd | 18192627656 | 1012@dideu.com | China | 2996 | 58 |
Alpha Biopharmaceuticals Co., Ltd | +86-15542445688 | sales@alabiochem.com | China | 888 | 58 |
GenicBio Limited | +86-21-37621270 | service@genicbio.com | CHINA | 991 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29825 | 58 |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 13239 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12449 | 58 |
View Lastest Price from N-Methyl-L-proline manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-08-05 | N-Methyl-L-proline
475-11-6
|
US $1.00-22.00 / KG | 1KG | 99% | 100000KG | Shaanxi Dideu Medichem Co. Ltd | ||
2023-01-31 | N-METHYL-L-PROLINE MONOHYDRATE
475-11-6
|
US $100.00 / KG | 1KG | 99% | 5000kg/week | Hebei Mojin Biotechnology Co., Ltd | ||
2022-02-19 | N-Methyl-l-proline
475-11-6
|
US $0.00 / KG | 1KG | 97.8% | 100 tons | Honest Joy Holdings Limited
|
- N-Methyl-L-proline
475-11-6
- US $1.00-22.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
- N-METHYL-L-PROLINE MONOHYDRATE
475-11-6
- US $100.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
- N-Methyl-l-proline
475-11-6
- US $0.00 / KG
- 97.8%
- Honest Joy Holdings Limited
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