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4'-Nitroacetanilide

4'-Nitroacetanilide structure

CAS No.: 104-04-1

Chemical Name:: 4'-Nitroacetanilide

Synonyms: NSC 1315;P-NITROACETANILIDE;p-nitro-acetanilid;4-NITROACETANILIDE;4'-NITROACETANILIDE;4'-Nitroacetanilide;Acetanilide, p-nitro-;acetanilide,4’-nitro-;4-Nitroacetanilide 98%;LABOTEST-BB LT00455738

CBNumber:: CB1191136

Molecular Formula:: C8H8N2O3

Molecular Weight:: 180.16

MDL Number:: MFCD00007303

MOL File:: 104-04-1.mol

Last updated:2023-04-23 13:52:06

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4'-Nitroacetanilide Properties

Melting point	213-215 °C(lit.)
Boiling point	312.97°C (rough estimate)
Density	1.340
refractive index	1.6180 (estimate)
storage temp.	Store below +30°C.
solubility	2.2g/l
pka	13.91±0.70(Predicted)
form	Solid
color	Yellow to green-yellow or green-brown
Water Solubility	2.2g/L(room temperature)
Merck	14,6581
BRN	2211962
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference	104-04-1(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	PH3B066365
EPA Substance Registry System	Acetamide, N-(4-nitrophenyl)- (104-04-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

RTECS

AE5075000

TSCA

Yes

HS Code

29242990

Toxicity

rat,LDLo,intraperitoneal,500mg/kg (500mg/kg),National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 10, 1953.

NFPA 704

	1
2		0

4'-Nitroacetanilide price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.20880	4′-Nitroacetanilide for synthesis	104-04-1	25G	$53.6	2024-03-01	Buy
Sigma-Aldrich	8.20880	4′-Nitroacetanilide for synthesis	104-04-1	100G	$204	2024-03-01	Buy
Sigma-Aldrich	130648	4-Nitroacetanilide 98%	104-04-1	5g	$41.6	2024-03-01	Buy
TCI Chemical	N0108	4'-Nitroacetanilide >99.0%(GC)	104-04-1	25g	$78	2024-03-01	Buy
TCI Chemical	N0108	4'-Nitroacetanilide >99.0%(GC)	104-04-1	500g	$673	2024-03-01	Buy

Product number	Packaging	Price	Buy
8.20880	25G	$53.6	Buy
8.20880	100G	$204	Buy
130648	5g	$41.6	Buy
N0108	25g	$78	Buy
N0108	500g	$673	Buy

4'-Nitroacetanilide Chemical Properties,Uses,Production

Chemical Properties

solid

Uses

4-Nitroacetanilide was used as a test substrate and its hydrolysis was determined by UV spectroscopic measurements. It was also used to prepare 4-aminoacetanilide.

Uses

Manufacture of nitraniline.

Preparation

Preparation of 4'-Nitroacetanilide from acetanilide.
Principle: Aromatic compounds can be conveniently nitrated by the use of the nitrating mixture, which is normally a mixture of concentrated nitric acid and concentrated sulphuric acid. The function of sulphuric acid is to convert nitric acid into a highly reactive, electrophilic, nitronium ion, NO2+, which is the effective nitrating agent. Nitration of activated aromatic compounds is carried out under milder condition whereas deactivated rings require drastic conditions. Activating groups are o, p-directing, while deactivating groups are m-directing for electrophilic substitution.
Reaction:
Preparation of 4'-Nitroacetanilide from acetanilide
Procedure: Take 0.5 g acetanilide in 0.6 ml glacial acetic acid and add 1 ml conc. H2SO4 in a beaker. Cool the mixture in ice salt bath (5-10°C). To this add a mixture of 0.2 ml conc. H2SO4 and 0.25 ml conc. HNO3 dropwise. Maintain the temperature below 10°C during addition. After addition is over allow the mixture to attain room temperature and leave it for 30 minutes. Pour the mixture on to crushed ice (20 g) with stirring. Filter the separated product and wash with cold water. Dry the product, record the practical yield and re-crystallize it.
Re-crystallization: Dissolve the crude product in minimum amount of ethyl alcohol in a beaker by heating on a water bath. Filter the hot solution and cool the filtrate. The crystals of the product separate out. Filter, dry and record the melting point and TLC (using toluene as solvent).

Synthesis Reference(s)

Journal of the American Chemical Society, 75, p. 5905, 1953 DOI: 10.1021/ja01119a037
Tetrahedron Letters, 28, p. 1669, 1987 DOI: 10.1016/S0040-4039(00)95389-9

Purification Methods

Precipitate the anilide from 80% H2SO4 by adding ice, then wash with water, and crystallise from aqueous EtOH. Dry it in air. [Beilstein 12 IV 1632.]

4'-Nitroacetanilide Preparation Products And Raw materials

Raw materials

Preparation Products

N-Methyl-4-nitroaniline 5-Amino-2-nitrobenzoic acid 4'-Aminoacetanilide N,N-Dimethyl-N'-(4-nitrophenyl)formamidine 4-NITROANILINE HYDROCHLORIDE

2,6-DICHLORO-1,4-BENZOQUINONE 4-NITRO-2-(TRIFLUOROMETHYL)ACETANILIDE N1-(3-Aminophenyl)acetamide 2-Amino-5-nitrobenzophenone 6-NITROQUINOLINE

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4'-Nitroacetanilide Suppliers

Global( 195)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29881	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17365	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	China	52849	58
Changzhou Anxuan Chemical Co., Ltd	+86-0519-89882563 +86-18961279162	andy@anxuanchem.com	China	4327	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Changzhou Anxuan Chemical Co., Ltd	58

View Lastest Price from 4'-Nitroacetanilide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-08-12	4"-NITROACETANILIDE 104-04-1	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-02	4"-Nitroacetanilide 104-04-1	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06	4'-NITROACETANILIDE 104-04-1	US $1.00 / kg	1kg	95%-99%	100kg	Career Henan Chemical Co

4"-NITROACETANILIDE
104-04-1
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

4"-Nitroacetanilide
104-04-1
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

4'-NITROACETANILIDE
104-04-1
US $1.00 / kg
95%-99%
Career Henan Chemical Co

4'-Nitroacetanilide Spectrum

4'-Nitroacetanilide(104-04-1)MS 4'-Nitroacetanilide(104-04-1)¹HNMR 4'-Nitroacetanilide(104-04-1)¹³CNMR 4'-Nitroacetanilide(104-04-1)IR1 4'-Nitroacetanilide(104-04-1)IR2 4'-Nitroacetanilide(104-04-1)Raman

104-04-1(4'-Nitroacetanilide)Related Search:

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N-(2-METHOXY-4-NITROPHENYL)ACETAMIDE 1-ACETYL-5-NITROINDOLINE 2,4-DINITROACETANILIDE 5-Nitroisatin 4'-Nitroacetanilide

5-Chloro-2-Nitroacetanilide ALPHA-CHLORO-3-NITROACETANILIDE,N-CHLORO-3-NITROACETANILIDE,Chloro-3-nitroacetanilide, 98% O-NITROACETANILIDE ALPHA-CHLORO-2-NITROACETANILIDE,ALPHA-CHLORO-NITROACETANILIDE,ó-chloro-2-nitroacetanilid 4-chloro-3-nitroacetanilide

4-METHOXY-3-NITROACETANILIDE 2-Methoxy-2-Nitroacetanilide,4-METHOXY-2-NITROACETANILIDE,4'-METHOXY-2'-NITROACETANILIDE 3-Nitroacetanilide, 98+%,M-NITROACETANILIDE

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P-NITROACETANILIDE N-ACETYL-4-NITROANILINE 4-Nitroacetanilide, GC 97% LABOTEST-BB LT00455738 p-nitro-acetanilid p-Nitrophenylacetanilide 4μ-Nitroacetanilide, Acetic acid 4-nitroanilide 4'-Nitroacetanilide,97%,pract. 4-(Acetylamino)nitrobenzene NSC 1315 4-Nitroacetanilide 98% 4''-NITROACETANILIDE 99+% 1-Nitro-4-acetylaminobenzene 4'-NITROACETANILIDE 4-NITROACETANILIDE ACETIC ACID 4-NITROANILIDE Acetamide, N-(4-nitrophenyl)- acetamide,N-(4-nitrophenyl)- Acetanilide, 4'-nitro- Acetanilide, p-nitro- acetanilide,4’-nitro- n-(4-nitrophenyl)-acetamid N-(4-Nitrophenyl)acetamide N-(4-Nitrophenyl)aceticacidamide N-(p-Nitrophenyl)acetamide N-Acetyl-4-nitrobenzenamine N-Acetyl-p-nitroaniline p-Acetamidonitrobenzene Pera nitro Acetanilide 4'-Nitroacetanilide> 4'-NITROACETANILIDE FOR SYNTHESIS 104-04-1 C8H8N2O3 4'-NITROACETANILIDE ParaNitro ACETANILIDE (PNA) 4'-Nitroacetanilide 104-04-1 Building Blocks Nitrogen Compounds Organic Building Blocks Protected Amines Intermediates of Dyes and Pigments Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts Anilines, Amides & Amines Nitro Compounds