BCTC
- CAS No.
- 393514-24-4
- Chemical Name:
- BCTC
- Synonyms
- BCTC;N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide;4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide;1-Piperazinecarboxamide, 4-(3-chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-;4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-diMethylethyl)phenyl]-1-piperazinecarboxaMide (BCTC)
- CBNumber:
- CB12122071
- Molecular Formula:
- C20H25ClN4O
- Molecular Weight:
- 372.89
- MDL Number:
- MFCD08690556
- MOL File:
- 393514-24-4.mol
- MSDS File:
- SDS
| Melting point | 150-152℃ |
|---|---|
| Boiling point | 561.6±50.0 °C(Predicted) |
| Density | 1.229±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: >10mg/mL |
| pka | 13.95±0.70(Predicted) |
| form | powder |
| color | white to beige |
| Sensitive | Light Sensitive |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stord at -20°C for up to 2 months. |
| InChIKey | ROGUAPYLUCHQGK-UHFFFAOYSA-N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264b-P270-P301+P312-P330-P403-P501c | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
BCTC price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0355 | BCTC ≥98% (HPLC) | 393514-24-4 | 5mg | $96.7 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0355 | BCTC ≥98% (HPLC) | 393514-24-4 | 25mg | $314 | 2024-03-01 | Buy |
| Alfa Aesar | J67361 | BCTC, 98% | 393514-24-4 | 50mg | $507 | 2021-12-16 | Buy |
| Alfa Aesar | J67361 | BCTC, 98% | 393514-24-4 | 10mg | $172 | 2021-12-16 | Buy |
| Cayman Chemical | 10006309 | BCTC ≥98% | 393514-24-4 | 5mg | $41 | 2024-03-01 | Buy |
BCTC Chemical Properties,Uses,Production
Description
BCTC (393514-24-4) is a vanilloid receptor I (TRPV1) blocker, IC50 = 35 nM for capsaicin-induced and 6 nM for acid-induced TRPV1 activation. Displays analgesic activity in rat models of neuropathic pain. BCTC is orally active and cell permeable.
Uses
BCTC is a antagonists of TRPA1 and TRPV1, a non-selective cation channel gated by noxious heat, vanilloids and extracellular protons. BCTC inhibits both capsaicin and proton activation.
Definition
ChEBI: 1-piperazinecarboxamide, 4-(3-chloro-2-pyridinyl)-n-[4-(1,1-dimethylethyl)phenyl]- is a member of piperazines and a member of pyridines.
storage
Room temperature
References
1) Valenzano et al. (2003), N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties; J. Pharmacol. Exp. Ther., 306 377 2) Pomonis et al. (2003), N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropathic pain; J. Pharmacol. Exp. Ther., 306 387
BCTC Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32951 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29814 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32070 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38463 | 58 | |
| PT CHEM GROUP LIMITED | peter68@ptchemgroup.com | China | 35425 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49979 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
