WP631
- CAS No.
- Chemical Name:
- WP631
- Synonyms
- WP631;WP631 2HCL
- CBNumber:
- CB1218211
- Molecular Formula:
- C62H66Cl2N2O20
- Molecular Weight:
- 1230.09
- MDL Number:
- MFCD08061905
- MOL File:
- Mol file
WP631 Chemical Properties,Uses,Production
Description
WP631 is a novel bisintercalating anthracycline. Potent inhibitor of Sp1-activated transcription.1,2 Induces caspase-dependent apoptosis in human ovarian cancer cells.3 Synergizes with epothilone at induction of apoptosis in human ovarian cancer cells.4? Abrogates HIV-1 replication via inhibition of Tat transactivation.5
References
Martin et al. (1999), Bisanthracycline WP631 inhibits basal and Sp-1-activated transcription initiation in vitro; Nucleic Acids Res,, 27 3402 Mansilla et al. (2004), Sp1-targeted inhibition of gene transcription by WP631 in transfected lymphocytes; Biochemistry, 43 7584 Gajek et al. (2014), Pro-apoptotic activity of new analog of anthracyclines—WP 631 in advanced ovarian cancer cell line; In Vitro, 28 273 Bukowska et al. (2016), New Potential chemotherapy for ovarian cancer – Combined therapy with WP 631 and epothilone B; Life Sci., 151 86 Kutsch et al. (2004), Bis-anthracycline antibiotics inhibit human immunodeficiency virus type 1 transcription; Antimicrob. Agents Chemother., 43 1652
WP631 Preparation Products And Raw materials
Raw materials
Preparation Products
WP631 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Focus Biomolecules | -- | sales@focusbiomolecules.com | United States | 1284 | 58 |
Fluorochem Ltd | -- | vernam@fluorochem.co.uk | United Kingdom | 6383 | 65 |
A.G. Scientific, Inc. | -- | support@agscientific.com | United States | 1066 | 71 |
EMD Biosciences, Inc. | -- | technical@calbiochem.com | United States | 6529 | 66 |
Fluorochem Ltd. | -- | enquiries@fluorochem.co.uk | United Kingdom | 6406 | 74 |
VWR International | -- | solutions@vwr.com | United Kingdom | 6554 | 82 |
Supplier | Advantage |
---|---|
Focus Biomolecules | 58 |
Fluorochem Ltd | 65 |
A.G. Scientific, Inc. | 71 |
EMD Biosciences, Inc. | 66 |
Fluorochem Ltd. | 74 |
VWR International | 82 |