Hydrocortisone-17-butyrate
- CAS No.
- 13609-67-1
- Chemical Name:
- Hydrocortisone-17-butyrate
- Synonyms
- HYDROCORTISONE BUTYRATE;HYDROCORTISONE 17-BUTYRATE;Alfason;h.17b;locoid;Plancol;Laticort;hb(sub17);Nicotine Impurity 8;CORTISOL 17-BUTYRATE
- CBNumber:
- CB1230781
- Molecular Formula:
- C25H36O6
- Molecular Weight:
- 432.56
- MDL Number:
- MFCD00083364
- MOL File:
- 13609-67-1.mol
- MSDS File:
- SDS
| Melting point | 210.0 to 214.0 °C |
|---|---|
| Boiling point | 466.2°C (rough estimate) |
| Density | 1.0914 (rough estimate) |
| refractive index | 1.4593 (estimate) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 12.98±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| Merck | 14,4787 |
| InChIKey | BMCQMVFGOVHVNG-IZBZUILHNA-N |
| SMILES | O([C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C)C(=O)CO)C(=O)CCC |&1:1,4,6,16,18,20,23,r| |
| CAS DataBase Reference | 13609-67-1(CAS DataBase Reference) |
| FDA UNII | 05RMF7YPWN |
| ATC code | D07AB02 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| WGK Germany | 2 |
| RTECS | GM9002000 |
| HS Code | 2937290000 |
Hydrocortisone-17-butyrate price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H5270 | Hydrocortisone 17-butyrate | 13609-67-1 | 1g | $132 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1317302 | Hydrocortisone butyrate United States Pharmacopeia (USP) Reference Standard | 13609-67-1 | 200mg | $436 | 2024-03-01 | Buy |
| TCI Chemical | H1506 | Hydrocortisone 17-Butyrate >98.0%(HPLC) | 13609-67-1 | 200mg | $40 | 2024-03-01 | Buy |
| TCI Chemical | H1506 | Hydrocortisone 17-Butyrate >98.0%(HPLC) | 13609-67-1 | 1g | $125 | 2024-03-01 | Buy |
| TRC | H714605 | Hydrocortisone butyrate | 13609-67-1 | 2.5g | $160 | 2021-12-16 | Buy |
Hydrocortisone-17-butyrate Chemical Properties,Uses,Production
Description
Hydrocortisone 17-butyrate: a new non-fluorinated topical corticosteroid.
Hydrocortisone 17-butyrate could be used in psoriasis, eczema and other inflammatory dermatoses. It may be found in creams, lotions, ointments, and powders and in ear, nose and eye drops for rhinitis, otitis, and conjunctivitis. In double-blind paired comparisons with other topical corticosteroids, the efficacy of hydrocortisone 17-butyrate 0.1% has generally been indistinguishable from that of triamcinolone acetonide 0.1%, fluocinolone acetonide 0.025% or betamethasone 17-valerate 0.1% in patients with eczema or psoriasis. When applied to the face of patients with atrophy superimposed on rosacea and perioral dermatitis resulting from prolonged use of fluorinated topical corticosteroids, hydrocortisone 17-butyrate 0.1% did not prevent the beneficial effect of systemic tetracycline nor the disappearance of telangiectasis and tended to be more effective than hydrocortisone 1%[1].
Uses
Hydrocortisone Butyrate is a topical corticosteroid use to treat a variety of dermatological conditions. It acts as an antiinflammatory, antiproliferative and immunosuppresive agent.
Uses
antineoplastic
Uses
Hydrocortisone-17-butyrate is a topical corticosteroid with anti-inflammatory properties; marker for topical corticosteroid allergy.
Definition
ChEBI: Cortisol esterified with butyric acid at the 17-hydroxy group.
brand name
Locoid (Ferndale); Locoid (Yamanouchi).
Biochem/physiol Actions
Hydrocortisone 17-butyrate is a corticosteroid that acts as a dermocorticoid due to its application in dermatological therapy. It exhibits therapeutic effects against vitiligo of the face and neck.
Contact allergens
Hydrocortisone 17-butyrate is a C 17 ester of hydrocorti- sone. It represents the D2 group of corticosteroids, non C 16 methylated with a C 17 ester: hydrocortisone 17-butyrate, hydrocortisone 17-valerate, hydrocortisone aceponate (17-propionate and 21-acetate), methylpred- nisolone aceponate, and prednicarbate. It is sometimes hydrolyzed in vivo into hydrocortisone, giving allergic reactions to group-A-sensitized people.
References
[1] R N Brogden. “Hydrocortisone 17-butyrate: a new topical corticosteroid preliminary report.” ACS Chemical Neuroscience 12 4 (1976): 249–57.
Hydrocortisone-17-butyrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Protheragen-ING | +16313385890 | info@protheragen-ing.com | United States | 3868 | 58 |
| Hebei Kangcang new material Technology Co., LTD | +8615713292910 | Nancy@kangcang.com.cn | China | 341 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | sales@amoychem.com | China | 6383 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Hebei shuoxi biotechnology co. LTD | +8613081092107 | CHINA | 964 | 58 |
View Lastest Price from Hydrocortisone-17-butyrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Hydrocortisone 17-butyrate
13609-67-1
|
US $29.00-77.00 / mg | 99.01% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | Hydrocortisone 17-butyrate
13609-67-1
|
US $29.00-77.00 / mg | 99.01% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-05-11 | Hydrocortisone-17-butyrate
13609-67-1
|
US $20.00-10.00 / kg | 1kg | 98% | 20 | Hebei Kangcang new material Technology Co., LTD |
-
- Hydrocortisone 17-butyrate
13609-67-1
- US $29.00-77.00 / mg
- 99.01%
- TargetMol Chemicals Inc.
-
- Hydrocortisone 17-butyrate
13609-67-1
- US $29.00-77.00 / mg
- 99.01%
- TargetMol Chemicals Inc.
-
- Hydrocortisone-17-butyrate
13609-67-1
- US $20.00-10.00 / kg
- 98%
- Hebei Kangcang new material Technology Co., LTD