Nicardipine hydrochloride
- CAS No.
- 54527-84-3
- Chemical Name:
- Nicardipine hydrochloride
- Synonyms
- YC-93;dafil;dagan;loxen;lincil;Vasonas;Dacarel;Barizin;Aprovan;NICODEL
- CBNumber:
- CB1244267
- Molecular Formula:
- C26H30ClN3O6
- Molecular Weight:
- 515.99
- MDL Number:
- MFCD00057327
- MOL File:
- 54527-84-3.mol
Melting point | 176-1780C |
---|---|
storage temp. | 2-8°C |
solubility | DMSO: ~1 mg/mL |
form | powder |
color | yellow |
Merck | 14,6495 |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in distilled water or ethanol may be stored at -20°C for up to 1 month. |
InChIKey | AIKVCUNQWYTVTO-UHFFFAOYSA-N |
CAS DataBase Reference | 54527-84-3(CAS DataBase Reference) |
FDA UNII | K5BC5011K3 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS06 |
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Signal word | Danger | |||||||||
Hazard statements | H301+H311+H331 | |||||||||
Precautionary statements | P280-P301+P310+P330-P302+P352+P312-P304+P340+P311 | |||||||||
Hazard Codes | T | |||||||||
Risk Statements | 23/24/25 | |||||||||
Safety Statements | 36/37/39-45 | |||||||||
RIDADR | UN 2811 6.1/PG 3 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | US7972100 | |||||||||
HazardClass | 6.1(b) | |||||||||
PackingGroup | III | |||||||||
HS Code | 2933399090 | |||||||||
Toxicity | LD50 in male, female rats (mg/kg): 634, 557 orally; 18.1, 25.0 i.v.; in male, female mice: 634, 650 orally; 20.7, 19.9 i.v. (Odani, Sado) | |||||||||
NFPA 704 |
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Nicardipine hydrochloride price More Price(32)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | N7510 | Nicardipine hydrochloride powder, ≥98% | 54527-84-3 | 1g | $132 | 2024-03-01 | Buy |
Sigma-Aldrich | PHR2531 | Nicardipine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 54527-84-3 | 500MG | $267 | 2024-03-01 | Buy |
Sigma-Aldrich | 1463224 | Nicardipine hydrochloride United States Pharmacopeia (USP) Reference Standard | 54527-84-3 | 200mg | $436 | 2024-03-01 | Buy |
Sigma-Aldrich | Y0001924 | Nicardipine hydrochloride European Pharmacopoeia (EP) Reference Standard | 54527-84-3 | Y0001924 | $148 | 2023-06-20 | Buy |
Sigma-Aldrich | Y0001917 | Nicardipine for system suitability European Pharmacopoeia (EP) Reference Standard | 54527-84-3 | Y0001917 | $201 | 2023-06-20 | Buy |
Nicardipine hydrochloride Chemical Properties,Uses,Production
Description
Nicardipine is a dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity. It is reported to inhibit adenosine A1, A2A, and A3 receptors with Ki values of 19.6, 63.8, and 3.25 μM, respectively, and can inhibit cytochrome P450 3A4 catalytic activity with an IC50 value of 0.148 μM. Additionally, nicardipine has been shown to activate transient receptor potential A1 channels, producing an increase in Ca2+ (EC50 = 0.5 μM).
Chemical Properties
Yellow Solid
Uses
Dihydropyridine calcium channel blocker. Antianginal; antihypertensive
Uses
Nicardipine is a dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity. It is reported to inhibit adenosine A1, A2A, and A3 receptors with Ki values of 19.6, 63.8, and 3.25 μM, respectively, and can inhibit cytochrome P450 3A4 catalytic activity with an IC50 value of 0.148 μM. Additionally, nicardipine has been shown to activate transient receptor potential A1 channels, producing an increase in Ca2+ (EC50 = 0.5 μM).
Uses
anesthetic (topical)
Definition
ChEBI: Nicardipine hydrochloride is a dihydropyridine. It has a role as a geroprotector.
brand name
Cardene(PDL Biopharma); Cardene (Roche).
General Description
Nicardipine hydrochloride,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid methyl 2-[methyl(phenylmethyl)amino]ethylester hydrochloride (Cardene), is a more potent vasodilator ofthe systemic, coronary, cerebral, and renal vasculature andhas been used in the treatment of mild, moderate, and severehypertension. The drug is also used in the management of stableangina.
Biochem/physiol Actions
Blocks L-type voltage-dependent calcium channels; antihypertensive.
Clinical Use
Calcium-channel blocker:
Prophylaxis and treatment of angina
Mild to moderate hypertension
Acute life-threatening hypertension and post operative hypertension (IV)
Safety Profile
Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by subcutaneous route. Human systemic effects: decreased urine volume or anuria. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx an
Drug interactions
Potentially hazardous interactions with other drugs
Aminophylline: possibly increases aminophylline
concentration.
Anaesthetics: enhanced hypotensive effect.
Antibacterials: metabolism possibly accelerated
by rifampicin; metabolism possibly inhibited by
clarithromycin, erythromycin and telithromycin.
Antidepressants: enhanced hypotensive effect with
MAOIs.
Antiepileptics: effect reduced by carbamazepine,
barbiturates, phenytoin and primidone.
Antifungals: metabolism possibly inhibited by
itraconazole and ketoconazole; negative inotropic
effect possibly increased with itraconazole.
Antihypertensives: enhanced hypotensive effect,
increased risk of first dose hypotensive effect of post synaptic alpha-blockers.
Antivirals: concentration possibly increased by
ritonavir; use telaprevir with caution.
Cardiac glycosides: digoxin concentration increased.
Ciclosporin: concentration of ciclosporin increased
Grapefruit juice: concentration increased - avoid.
Tacrolimus: may increase tacrolimus levels.
Theophylline: possibly increased theophylline
concentration.
Metabolism
Nicardipine is subject to saturable first-pass metabolism. It is extensively metabolised in the liver and excreted in the urine and faeces, mainly as inactive metabolites.
References
1) Merck 14 6495 2) Hulubei et al. (2012), 4-Isoxazolyl-1,4-dihydropyridines exhibit binding at the multidrug-resistance transporter; Bioorg. Med. Chem., 20 6620
Nicardipine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | peter@yan-xi.com | China | 5872 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 | sales06@airuikechemical.com | China | 983 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9332 | 55 |
Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5909 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29825 | 58 |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 13239 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12449 | 58 |
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- Aug 28,2019
View Lastest Price from Nicardipine hydrochloride manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2024-08-15 | Nicardipine hydrochloride
54527-84-3
|
US $50.00-16.00 / kg | 1kg | 0.99 | 20 tons | Hebei Yanxi Chemical Co., Ltd. | |
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2024-04-09 | nicardipine hydrochloride
54527-84-3
|
US $0.00-0.00 / Kg | 1Kg | 99.9% | 200tons | airuikechemical co., ltd. | |
![]() |
2023-09-06 | Nicardipine hydrochloride
54527-84-3
|
US $0.00 / KG | 1KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. |
-
- Nicardipine hydrochloride
54527-84-3
- US $50.00-16.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- nicardipine hydrochloride
54527-84-3
- US $0.00-0.00 / Kg
- 99.9%
- airuikechemical co., ltd.
-
- Nicardipine hydrochloride
54527-84-3
- US $0.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.