2-Phenyl-2-(1-piperidinyl)propane
- CAS No.
- 92321-29-4
- Chemical Name:
- 2-Phenyl-2-(1-piperidinyl)propane
- Synonyms
- PPP;Benzhexol Impurity 13;α-Dimethylbenzyl)piperidine;1-(a,a-dimethylbenzyl)piperidine;1-(α,α-DiMethylbenzyl)piperidine;2-Phenyl-2-(1-piperdinyl)propane;1-(2-Phenylpropan-2-yl)piperidine;2-phenyl-2-(1-piperidinyl)propane;1-(1-Methyl-1-phenylethyl)piperidine;Piperidine, 1-(1-methyl-1-phenylethyl)-
- CBNumber:
- CB1247930
- Molecular Formula:
- C14H21N
- Molecular Weight:
- 203.32
- MDL Number:
- MFCD07783011
- MOL File:
- 92321-29-4.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| NFPA 704 |
|
2-Phenyl-2-(1-piperidinyl)propane price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17799 | 2-Phenyl-2-(1-piperidinyl)propane ≥95% | 92321-29-4 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 17799 | 2-Phenyl-2-(1-piperidinyl)propane ≥95% | 92321-29-4 | 5mg | $183 | 2024-03-01 | Buy |
| Cayman Chemical | 17799 | 2-Phenyl-2-(1-piperidinyl)propane ≥95% | 92321-29-4 | 10mg | $341 | 2024-03-01 | Buy |
| Cayman Chemical | 17799 | 2-Phenyl-2-(1-piperidinyl)propane ≥95% | 92321-29-4 | 25mg | $745 | 2024-03-01 | Buy |
| TRC | P336010 | 2-Phenyl-2-(1-piperidinyl)propane | 92321-29-4 | 250mg | $870 | 2021-12-16 | Buy |
2-Phenyl-2-(1-piperidinyl)propane Chemical Properties,Uses,Production
Description
2-Phenyl-2-(1-piperidinyl)propane is an analog of phencyclidine that acts as a mechanism-based inactivator of human cytochrome P450 (CYP) 2B6 (Ki = 5.6 μM; IC50 = 5.1 μM). It is 15-fold more selective for inhibition of CYP2B6 over CYP2D6 and 40-60-fold more selective for CYP2B6 over CYP1A2, CYP2A6, CYP2Cs, and CYP3A.
Chemical Properties
Colorless to Light Yellow Oil
Uses
Enzyme inhibitor. A selective inactivator of CYP2B6.
in vitro
previous study found that 2-phenyl-2-(1-piperidinyl)propane could inactivate the 7-(benzyloxy)resorufin o-dealkylation activity of liver microsomes obtained from phenobarbital-induced rats. the 7-ethoxy-4-(trifluoromethyl)coumarin o-deethylation activity of purified rat liver p450 2b1 and expressed human p450 2b6 was also inactivated by 2-phenyl-2-(1-piperidinyl)propane in a reconstituted system. with nadph, the loss of activity was founf to be both time- and concentration-dependent, and followed pseudo first order kinetics. the time for 50% of the p450 2b1 to become inactivated at saturating concentrations of 2-phenyl-2-(1-piperidinyl)propane was ~2.5 min. p450 2b6 was inactivated by 2-phenyl-2-(1-piperidinyl)propane with a k(inact) of 0.07 min(-1), a k(i) of 1.2 microm, and a t(1/2) of 9.5 min. the inactivated p450s 2b1 and 2b6 lost about 25 and 15%, respectively, indicating that the loss of activity was caused by a 2-phenyl-2-(1-piperidinyl)propane modification of the apoprotein rather than the heme [1].
References
[1] chun j, kent um, moss rm, sayre lm, hollenberg pf. mechanism-based inactivation of cytochromes p450 2b1 and p450 2b6 by 2-phenyl-2-(1-piperidinyl)propane. drug metab dispos. 2000 aug;28(8):905-11.
2-Phenyl-2-(1-piperidinyl)propane Preparation Products And Raw materials
Raw materials
Preparation Products
2-Phenyl-2-(1-piperidinyl)propane Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49476 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30233 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai ZhengXia Medical Technology Co., Ltd. | 13585673075 | 317388297@qq.com | China | 254 | 50 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
View Lastest Price from 2-Phenyl-2-(1-piperidinyl)propane manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | 2-Phenyl-2-(1-piperidinyl)propane
92321-29-4
|
US $47.00-163.00 / mg | 98.90% | 10g | TargetMol Chemicals Inc. |
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- 2-Phenyl-2-(1-piperidinyl)propane
92321-29-4
- US $47.00-163.00 / mg
- 98.90%
- TargetMol Chemicals Inc.