TPEN
- CAS No.
- 16858-02-9
- Chemical Name:
- TPEN
- Synonyms
- TPEN;TPEDA;CS-960;TPEN, >=98%;TPEN/CH63857;TPEN ISO 9001：2015 REACH;TPEN - CAS 16858-02-9 - Calbiochem;N,N'-Ethylenebis[bis(2-pyridyl)amine];TETRAKIS-(2-PYRIDYLMETHYL)ETHYLENEDIAMINE;N,N,N',N'-Tetra(2-pyridyl)-1,2-ethanediamine
- CBNumber:
- CB1249909
- Molecular Formula:
- C26H28N6
- Molecular Weight:
- 424.54
- MDL Number:
- MFCD00036918
- MOL File:
- 16858-02-9.mol
- MSDS File:
- SDS
| Melting point | 110-112 °C |
|---|---|
| Boiling point | 530.56°C (rough estimate) |
| Density | 1.3893 (rough estimate) |
| refractive index | 1.4570 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Soluble in DMSO (up to 10 mg/ml). |
| pka | 5.19±0.12(Predicted) |
| form | Tan solid |
| color | Off-white or tan |
| BRN | 4211982 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 16858-02-9(CAS DataBase Reference) |
| FDA UNII | R9PTU1U29I |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8-10-23 | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
TPEN price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P4413 | N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine | 16858-02-9 | 50mg | $100 | 2024-03-01 | Buy |
| Sigma-Aldrich | P4413 | N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine | 16858-02-9 | 100mg | $148 | 2024-03-01 | Buy |
| Sigma-Aldrich | 616394 | TPEN - CAS 16858-02-9 - Calbiochem | 16858-02-9 | 100mg | $192 | 2024-03-01 | Buy |
| TCI Chemical | T1487 | N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine >97.0%(T) | 16858-02-9 | 1g | $213 | 2024-03-01 | Buy |
| TCI Chemical | T1487 | N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine >97.0%(T) | 16858-02-9 | 5g | $722 | 2024-03-01 | Buy |
TPEN Chemical Properties,Uses,Production
Description
TPEN (16858-02-9) is a cell permeable metal chelator. Frequently used to study effects of zinc depletion on cellular processes.1,2
Chemical Properties
Colourless Crystals
Uses
Membrane-permeable zinc chelator; decreased the intracellular level of zinc and induced apoptosis.
Definition
ChEBI: An N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups.
Biochem/physiol Actions
N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) elicits pro-apoptotic effect in human acute promyelocytic NB4 cells by inhibiting nitric oxide signalling and Zn2+ signaling. In microglia pretreated with zinc, TPEN inhibits the interleukin 6 secretion and nitric oxide synthase (iNOS) mRNA expression. It induces damage on DNA structure by activating ATM (ataxia telangiectasia mutated) and ATR (ATM-Rad3-related) signaling in human colon cancer cells.
storage
Store at +4°C
References
1) Chimienti et al. (2001) Role of cellular zinc in programmed cell death: temporal relationship between zinc depletion, activation of caspases and cleavage of Sp family transcription factors; Biochem. Pharmacol. 62 51 2) Meplan et al. (2000) Metalloregulation of the tumor suppressor protein p53: zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells; Oncogene 19 5227
TPEN Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29811 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22783 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
View Lastest Price from TPEN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-17 | TPEN
16858-02-9
|
US $38.00-80.00 / mg | 99.79% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-10-28 | TPEN
16858-02-9
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2021-08-12 | TPEN
16858-02-9
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |