9-(Dimethylamino)-3-(hexahydro-1H-azepin-1-yl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one
![9-(Dimethylamino)-3-(hexahydro-1H-azepin-1-yl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one Structure](CAS/GIF/869802-58-4.gif)
- CAS No.
- 869802-58-4
- Chemical Name:
- 9-(Dimethylamino)-3-(hexahydro-1H-azepin-1-yl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one
- Synonyms
- A 841720;3-(azepan-1-yl)-9-(dimethylamino)pyrido[1,2]thieno[3,4-d]pyrimidin-4-one;3-(azepan-1-yl)-9-(dimethylamino)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one;9-(Dimethylamino)-3-(hexahydro-1H-azepin-1-yl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one;Pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one, 9-(dimethylamino)-3-(hexahydro-1H-azepin-1-yl)-
- CBNumber:
- CB12518960
- Molecular Formula:
- C17H21N5OS
- Molecular Weight:
- 343.45
- MDL Number:
- MFCD09970991
- MOL File:
- 869802-58-4.mol
9-(Dimethylamino)-3-(hexahydro-1H-azepin-1-yl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one Properties
| Boiling point | 539.9±60.0 °C(Predicted) |
|---|---|
| Density | 1.40±0.1 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | DMSO: soluble15mg/mL, clear |
| form | powder |
| pka | 9.90±0.20(Predicted) |
| color | white to beige |
| FDA UNII | U8C5C9D65S |
9-(Dimethylamino)-3-(hexahydro-1H-azepin-1-yl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0818 | A-841720 ≥98% (HPLC) | 869802-58-4 | 25mg | $375 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0818 | A-841720 ≥98% (HPLC) | 869802-58-4 | 5mg | $106 | 2022-05-15 | Buy |
| Cayman Chemical | 21807 | A-841720 ≥98% | 869802-58-4 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 21807 | A-841720 ≥98% | 869802-58-4 | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 21807 | A-841720 ≥98% | 869802-58-4 | 10mg | $153 | 2024-03-01 | Buy |
9-(Dimethylamino)-3-(hexahydro-1H-azepin-1-yl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one Chemical Properties,Uses,Production
Uses
A 841720 is a potent & non-competitive mGluR-1 antagonist.
Biological Activity
a 841720 is a novel non-competitive antagonist of metabotropic glutamate receptor 1 (mglur1), with an ic50 value of 10.7 nm to 10 μm l-glutamate-induced calcium release at human mglur1 receptors [1].glutamate as the major excitatory neurotransmitter in the central nervous system functions through two types of receptors, ionotropic glutamate receptors and metabotropic glutamate receptors (mglurs). mglurs includes group i mglurs (mglur1 and mglur5 receptors), group ii (mglur2 and mglur3 receptors) and group iii (mglur4, 6, 7, 8 receptors) [1].in cells, agonist-induced calcium release was concentration-dependently inhibited by a 841720 in a human mglur5 receptor flipr functional assay. but the ic50 value was just 343 nm. in cells expressing recombinant mglur5 receptors, a 841720 did not block agonist-induced response. in the human mglur1 receptor flipr assay, the log concentration-response curve was shifted by a 841720 at 10 nm to the right. a 841720 at increasing concentrations profoundly reduced the amplitude of l-quisqualate-evoked calcium release. a 841720 at 30 nm reduced the maximal agonist-induced response by 38%. l-quisqualate-induced response was completely abolished by a 841720 at 100 nm [1].in a water maze test, all rats gradually learned to locate the submerged platform. treatment with a 841720 significantly slowered rats to find the platform than vehicle control rats. rats treated with a 841720 at both 30 and 100 μmol/kg doses not only significantly traveled longer distance to find the hidden platform, but also significantly spent longer time to reach the platform [1].
References
[1]. el-kouhen o, lehto sg, pan jb, et al. blockade of mglur1 receptor results in analgesia and disruption of motor and cognitive performances: effects of a-841720, a novel non-competitive mglur1 receptor antagonist. british journal of pharmacology, 2006, 149(6): 761-774.
9-(Dimethylamino)-3-(hexahydro-1H-azepin-1-yl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
9-(Dimethylamino)-3-(hexahydro-1H-azepin-1-yl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
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| Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd | 15317229551 | 15151849396@163.com | China | 995 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
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| JinOu Biomedical (Nanjing) Co., Ltd. | 13000000000 | jinoupharma@163.com | China | 11732 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23980 | 58 |