Hesperadin
- CAS No.
- 422513-13-1
- Chemical Name:
- Hesperadin
- Synonyms
- CS-408;Hesperadin;Hesperadine;Hesperadin, >=98%;Hesperadin USP/EP/BP;Hesperadin hydrochloride;Hesperadin (This product is unavailable in the U.S.);Hesperadin Hesperadine;(Z)-N-(2-Oxo-3-(phenyl((4-(piperidin-1-ylmethyl)phenyl)amino)methylene)indolin-5-yl)ethanesulf;(Z)-N-(2-oxo-3-(phenyl(4-(piperidin-1-ylmethyl)phenylamino)methylene)indolin-5-yl)ethanesulfonamide
- CBNumber:
- CB12537545
- Molecular Formula:
- C29H32N4O3S
- Molecular Weight:
- 516.65
- MDL Number:
- MFCD18074526
- MOL File:
- 422513-13-1.mol
| Melting point | 228 °C |
|---|---|
| Density | 1.326 |
| storage temp. | Refrigerator |
| solubility | DMSO, Methanol |
| form | Solid |
| pka | 9.14±0.20(Predicted) |
| color | Yellow |
| CAS DataBase Reference | 422513-13-1 |
| FDA UNII | PTR491OS14 |
Hesperadin price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 375680 | Hesperadin - CAS 422513-13-1 - Calbiochem Hesperadin primarily used in Inhibition. | 422513-13-1 | 5mg | $280 | 2024-03-01 | Buy |
| Cayman Chemical | 24199 | Hesperadin ≥98% | 422513-13-1 | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 24199 | Hesperadin ≥98% | 422513-13-1 | 5mg | $202 | 2024-03-01 | Buy |
| Cayman Chemical | 24199 | Hesperadin ≥98% | 422513-13-1 | 10mg | $310 | 2024-03-01 | Buy |
| Cayman Chemical | 24199 | Hesperadin ≥98% | 422513-13-1 | 25mg | $711 | 2024-03-01 | Buy |
Hesperadin Chemical Properties,Uses,Production
Description
Hesperadin is a multi-kinase inhibitor. It inhibits human Aurora kinase B (IC50 = 250 nM) and its T. brucei homolog Aurora kinase-1 (IC50 = 40 nM) in in vitro kinase assays. Hesperadin (1 μM) inhibits AMPK, LCK, MKK1, MAPKAP-K1, CHK1, and PHK in a panel of 25 kinases. It also inhibits MEKK2 in ATPase and transphosphorylation assays with IC50s of 60 and 34 nM, respectively. Hesperadin (50-100 nM) induces polyploidy and defects in cytokinesis and spindle assembly as well as inhibits proliferation of HeLa cells and overrides mitotic arrest induced by paclitaxel or monastrol . Hesperadin also induces toxicity in HepG2 cells with a toxic concentration (TC50) value of less than 0.2 μM. It inhibits replication of clinical isolates of influenza A and B viruses with EC50s ranging from 0.22 to 2.21 μM in a plaque formation assay. Hesperadin inhibits the growth of T. brucei, L. major promastigotes and amastigotes, and P. falciparum with EC50 values ranging from 0.01 to 2.37 μM, but has less activity against T. cruzi (EC50 = 39 μM).
Uses
Hesperadin phosphorylates human mitotic protein complexes that control physiological changes within the cell to allow for proper and successful chromosome segregation. It also targets aurora kinases in cancer treatment, affecting the chromosomes’ regulation during mitosis.
Definition
ChEBI: An oxindole that is indolin-2-one which is substituted at position 5 by an (ethylsulfonyl)nitrilo group and at position 2 by a methylidene group, which is itself substituted by a phenyl group and a [4-(piperidin-1-ylmethyl)phenyl]amino group. An Aurora B k nase inhibitor, it is used to inhibit chromosome alignment and segregation.
References
[1]jetton n1, rothberg kg, hubbard jg, wise j, li y, ball hl, ruben l. the cell cycle as a therapeutic target against trypanosoma brucei: hesperadin inhibits aurora kinase-1 and blocks mitotic progression in bloodstream forms. mol microbiol. 2009 apr;72(2):442-58. doi: 10.1111/j.1365-2958.2009.06657.x. epub 2009 mar 6.
[2]hauf s1, cole rw, laterra s, zimmer c, schnapp g, walter r, heckel a, van meel j, rieder cl, peters jm. the small molecule hesperadin reveals a role for aurora b in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. j cell biol. 2003 apr 28;161(2):281-94. epub 2003 apr 21.
Hesperadin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32951 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29815 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 23125 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38463 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from Hesperadin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | Hesperadin
422513-13-1
|
US $1.00 / g | 1g | 99% | 1ton | Career Henan Chemical Co |
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- Hesperadin
422513-13-1
- US $1.00 / g
- 99%
- Career Henan Chemical Co