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17-phenyl trinor Prostaglandin F2α diethyl amide

17-phenyl trinor Prostaglandin F2α diethyl amide Structure
17-phenyl trinor Prostaglandin F2α diethyl amide structure
CAS No.
1176637-26-5
Chemical Name:
17-phenyl trinor Prostaglandin F2α diethyl amide
Synonyms
Bimatoprost diethyl amide;17-phenyl trinor Prostaglandin F2α diethyl amide;17-phenyl trinor Prostaglandin F2α diethyl amide;(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N,N-diethylhept-5-enamide;5-Heptenamide, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N,N-diethyl-, (5Z)-
CBNumber:
CB12589948
Molecular Formula:
C27H41NO4
Molecular Weight:
443.62
MDL Number:
MFCD03412002
MOL File:
1176637-26-5.mol
Last updated:2023-06-08 09:03:09
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17-phenyl trinor Prostaglandin F2α diethyl amide Properties

Boiling point 610.4±55.0 °C(Predicted)
Density 1.125±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml
pka 14.25±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07,GHS08
Signal word  Danger
Hazard statements  H225-H319-H360-H336
Precautionary statements  P201-P202-P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P308+P313-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501
NFPA 704
3
2 0

17-phenyl trinor Prostaglandin F2α diethyl amide price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16823 17-phenyl trinor Prostaglandin F2α diethyl amide ≥98% 1176637-26-5 1mg $71 2024-03-01 Buy
Cayman Chemical 16823 17-phenyl trinor Prostaglandin F2α diethyl amide ≥98% 1176637-26-5 5mg $313 2024-03-01 Buy
Cayman Chemical 16823 17-phenyl trinor Prostaglandin F2α diethyl amide ≥98% 1176637-26-5 10mg $554 2024-03-01 Buy
AK Scientific 6445DD (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N,N-diethylhept-5-enamide 1176637-26-5 1mg $176 2021-12-16 Buy
Product number Packaging Price Buy
16823 1mg $71 Buy
16823 5mg $313 Buy
16823 10mg $554 Buy
6445DD 1mg $176 Buy

17-phenyl trinor Prostaglandin F2α diethyl amide Chemical Properties,Uses,Production

Description

17-phenyl trinor Prostaglandin F2α diethyl amide (17-phenyl trinor PGF2α diethyl amide) is an analog of PGF2α in which the C-1 carboxyl group has been modified to an N-diethyl amide. PG esters have been shown to have ocular hypotensive activity.1 PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs.2 Studies have shown that bovine and human corneal tissue converts the N-ethyl amides of various PGs to the free acids with a conversion efficiency of about 2.5 μg/g corneal tissue/hr.3 However, dialkyl amides such as 17-phenyl trinor PGF2α diethyl amide are inert to corneal amidase activity, and are not converted in any detectable amount to the corresponding free acids. These compounds may therefore be useful tools in elucidating the claim that PG amides have intrinsic intraocular hypotensive activity.

References

1. Bito, L.Z. Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds Exp. Eye Res. 38,181-184(1984).
2. Woodward, D.F., Krauss, A.H., Chen, J., et al. The pharmacology of bimatoprost (Lumigan?) Surv. Ophthalmol. 45(Suppl 4),S337-S345(2001).
3. Maxey, K.M., Johnson, J., and LaBrecque, J. The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist Surv. Ophthalmol. 47(Suppl 1),S34-S40(2002).

17-phenyl trinor Prostaglandin F2α diethyl amide Preparation Products And Raw materials

Raw materials

Preparation Products

17-phenyl trinor Prostaglandin F2α diethyl amide Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 0571-85361029 synstar518@163.com China 1991 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8739 58
Supplier Advantage
Shanghai Hongye Biotechnology Co. Ltd 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
17-phenyl trinor Prostaglandin F2α diethyl amide (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N,N-diethylhept-5-enamide Bimatoprost diethyl amide 17-phenyl trinor Prostaglandin F2α diethyl amide 5-Heptenamide, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-N,N-diethyl-, (5Z)- 1176637-26-5