1-(1-(cyclooctylMethyl)-5-(hydroxyMethyl)-1,2,3,6-tetrahydropyridin-4-yl)-3-ethyl-1H-benzo[d]iMidazol-2(3H)-one hydrochloride
- CAS No.
- 1216621-00-9
- Chemical Name:
- 1-(1-(cyclooctylMethyl)-5-(hydroxyMethyl)-1,2,3,6-tetrahydropyridin-4-yl)-3-ethyl-1H-benzo[d]iMidazol-2(3H)-one hydrochloride
- Synonyms
- Trap-101 hydrochloride;Trap-101 hydrochloride >=98% (HPLC), powder;Trap 101 hydrochloride,Trap101 hydrochloride;1-[1-(cyclooctylmethyl)-5-(hydroxymethyl)-3,6-dihydro-2H-pyridin-4-yl]-3-ethylbenzimidazol-2-one:hydrochloride;1-(1-(cyclooctylMethyl)-5-(hydroxyMethyl)-1,2,3,6-tetrahydropyridin-4-yl)-3-ethyl-1H-benzo[d]iMidazol-2(3H)-one hydrochloride
- CBNumber:
- CB12609332
- Molecular Formula:
- C24H36ClN3O2
- Molecular Weight:
- 434.02
- MDL Number:
- MFCD09971083
- MOL File:
- 1216621-00-9.mol
1-(1-(cyclooctylMethyl)-5-(hydroxyMethyl)-1,2,3,6-tetrahydropyridin-4-yl)-3-ethyl-1H-benzo[d]iMidazol-2(3H)-one hydrochloride price More Price(5)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | T718518 | Trap101 | 1216621-00-9 | 2.5mg | $160 | 2021-12-16 | Buy |
TRC | T718518 | Trap101 | 1216621-00-9 | 25mg | $1260 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0008244 | TRAP-101 HYDROCHLORIDE 95.00% | 1216621-00-9 | 25MG | $1332.82 | 2021-12-16 | Buy |
ApexBio Technology | B7084 | Trap101 | 1216621-00-9 | 10mg | $322 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0008244 | TRAP-101 HYDROCHLORIDE 95.00% | 1216621-00-9 | 5MG | $824.56 | 2021-12-16 | Buy |
1-(1-(cyclooctylMethyl)-5-(hydroxyMethyl)-1,2,3,6-tetrahydropyridin-4-yl)-3-ethyl-1H-benzo[d]iMidazol-2(3H)-one hydrochloride Chemical Properties,Uses,Production
Uses
Trap 101 is a useful intermediate and used to study protein-coupled receptor
Biological Activity
Trap-101 hydrochloride is a potent, selective and competitive antagonist of NOP receptors, with selectivity for NOP receptors over other opioid receptors. Trap-101 stimulated GTPγ35S binding to CHOhNOP with pKi values of 8.65, 6.60, 6.14 and <5 for NOP, μ-, κ- and δ opioid receptors, respectively. Trap-101 attenuates motor deficits in Parkinson's disease rats and can be used for neurological disease research.
in vitro
Trap-101 hydrochloride (3, 30, and 300 nM) is inactive per se up to 10 μM, while in the range 3-300 nM, it produces a concentration dependent rightward shift of the concentration-response curve to N/OFQ without modifications of the maximal response to the agonist. Receptor binding affinities of Trap101 (pK i values) at recombinant human NOP, and classical opioid receptors expressed in CHO cell membranes are 8.65, 6.60, 6.14 and < 5 for NOP, μ-, κ-, and δ-opioid receptors respectively.
target
pKi: 8.65 (NOP receptor); 6.60 (μ-opioid receptor); 6.14 (κ-opioid receptor); < 5 (δ-opioid receptor)
1-(1-(cyclooctylMethyl)-5-(hydroxyMethyl)-1,2,3,6-tetrahydropyridin-4-yl)-3-ethyl-1H-benzo[d]iMidazol-2(3H)-one hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
1-(1-(cyclooctylMethyl)-5-(hydroxyMethyl)-1,2,3,6-tetrahydropyridin-4-yl)-3-ethyl-1H-benzo[d]iMidazol-2(3H)-one hydrochloride Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29786 | 68 |
BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
Jinan ponder chemical co. LTD | 0531-0000 | thinklifescience@163.com | China | 19690 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29778 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |
Supplier | Advantage |
---|---|
TargetMol Chemicals Inc. | 58 |
Beijing Solarbio Science & Tecnology Co., Ltd. | 68 |
BOC Sciences | 65 |
Jinan ponder chemical co. LTD | 58 |
Energy Chemical | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 58 |
ApexBio Technology | 58 |