CEP-32496 (free base)
- CAS No.
- 1188910-76-0
- Chemical Name:
- CEP-32496 (free base)
- Synonyms
- CS-1683;AC013773;RXDX-105;AC 013773;Agerafenib;RXDX-105 (CEP-32496);CEP-32496 (free base);AC-013773. Agerafenib;Agerafenib (RXDX-105);Agerafenib (CEP-32496)
- CBNumber:
- CB12627682
- Molecular Formula:
- C24H22F3N5O5
- Molecular Weight:
- 517.46
- MDL Number:
- MFCD22124524
- MOL File:
- 1188910-76-0.mol
- MSDS File:
- SDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | ≥25.85 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| form | A crystalline solid |
| color | White to off-white |
| CAS DataBase Reference | 1188910-76-0 |
| FDA UNII | 78I4VEX88N |
| NCI Drug Dictionary | agerafenib |
CEP-32496 (free base) price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18776 | CEP-32496 ≥95% | 1188910-76-0 | 500μg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 18776 | CEP-32496 ≥95% | 1188910-76-0 | 1mg | $74 | 2024-03-01 | Buy |
| Cayman Chemical | 18776 | CEP-32496 ≥95% | 1188910-76-0 | 5mg | $299 | 2024-03-01 | Buy |
| Cayman Chemical | 18776 | CEP-32496 ≥95% | 1188910-76-0 | 10mg | $381 | 2024-03-01 | Buy |
| TRC | C256660 | CEP32496 | 1188910-76-0 | 75mg | $1460 | 2021-12-16 | Buy |
CEP-32496 (free base) Chemical Properties,Uses,Production
Description
B-Raf is a MAP kinase kinase kinase, which functions downstream of Ras family GTPases to activate MEK1/2 and ERK1/2 signaling. Mutations of B-Raf, particularly at Val600, are common in melanomas and melanocytic nevi. CEP-32496 is a potent inhibitor of B-RafV600E (Kd = 14 nM in an in vitro binding assay). It blocks B-RafV600E-dependent phosphorylation of MEK in human melanoma A375 and colorectal cancer COLO 205 cells (IC50s = 78 and 60 nM, respectively). CEP-32496 binds kinases other than B-Raf but displays selective cytotoxicity for cells expressing B-RafV600E. It displays good oral bioavailability in rats, dogs, and monkeys and has single oral dose pharmacodynamics inhibition of both pMEK and pERK in B-RafV600E colon carcinoma xenografts in nude mice.
Uses
CEP 32496 is an orally active BRAFV600E inhibitor with selective cellular and in vivo antitumor activity.
References
[1] rowbottom mw1, faraoni r, chao q, campbell bt, lai ag, setti e, ezawa m, sprankle kg, abraham s, tran l, struss b, gibney m, armstrong rc,gunawardane rn, nepomuceno rr, valenta i, hua h, gardner mf, cramer md, gitnick d, insko de, apuy jl, jones-bolin s, ghose ak, herbertz t, ator ma,dorsey bd, ruggeri b, williams m, bhagwat s, james j, holladay mw. identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2 -methylpropan- 2-yl) isoxazol-3-yl) urea hydrochloride (cep-32496), a highly potent and orally efficacious inhibitor of v-raf murine sarcoma viral oncogene homologue b1 (braf) v600e. j med chem. 2012 feb 9;55(3):1082-105. doi: 10.1021/jm2009925. epub 2012 jan 23.
CEP-32496 (free base) Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32956 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29810 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 | sales@shengdapharm.com | CHINA | 310 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
View Lastest Price from CEP-32496 (free base) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-25 | CEP-32496 (free base)
1188910-76-0
|
US $9.80 / KG | 1g | ≥99% | 100kg | Career Henan Chemical Co |
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- CEP-32496 (free base)
1188910-76-0
- US $9.80 / KG
- ≥99%
- Career Henan Chemical Co